Reactome | p-S203,S221-TTC5 [nucleoplasm]

p-S203,S221-TTC5 [nucleoplasm]

Stable Identifier

R-HSA-6804259

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S203,S221-Strap

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8N0Z6 TTC5

Gene Names

TTC5

Chain

chain:1-440

Reference Genes

BioGPS Gene:91875 TTC5

COSMIC (genes):TTC5 TTC5

CTD Gene:91875 TTC5

dbSNP Gene:91875 TTC5

ENSEMBL:ENSG00000136319 TTC5

HGNC:19274 TTC5

KEGG Gene (Homo sapiens):91875 TTC5

Monarch:91875 TTC5

NCBI Gene:91875 TTC5

OMIM:619014 TTC5

UCSC:Q8N0Z6 TTC5

Reference Transcript

RefSeq:NM_138376.2 TTC5

Other Identifiers

0001090592

11733227_a_at

11763782_a_at

16789899

226557_PM_at

226557_at

243007_PM_at

243007_at

3555256

3555257

3555273

3555274

3555275

3555276

3555278

3555279

3555280

3555281

3555282

3555283

3555284

3555286

3555287

3555288

3555289

3555290

57384_r_at

58419_at

7977482

84634_r_at

91875

A_23_P88280

A_32_P96043

A_33_P3347108

GE79684

GO:0003674

GO:0003677

GO:0003682

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006259

GO:0006281

GO:0006950

GO:0006974

GO:0008150

GO:0009056

GO:0009058

GO:0009267

GO:0031410

GO:0034641

GO:0034655

GO:0043022

GO:0043226

GO:0045944

GO:0061014

HMNXSV003014996

Hs.102480.0.S1_3p_at

Hs.98553.0.A1_3p_at

ILMN_1681236

ILMN_1706455

PH_hs_0005440

PH_hs_0005682

TC14000877.hg

Participates

as a component of

p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Homo sapiens)

as an input of

JMY, TTC5 and EP300 bind (Homo sapiens)

as an output of

CHEK2 phosphorylates TTC5 (Homo sapiens)

Other forms of this molecule

p-S203-TTC5 [nucleoplasm]

TTC5 [nucleoplasm]

Inferred To

phospho-TTC5 [nucleoplasm] (Bos taurus)

phospho-TTC5 [nucleoplasm] (Canis familiaris)

phospho-TTC5 [nucleoplasm] (Sus scrofa)

phospho-p-S203,S221-TTC5 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S203,S221-TTC5 [nucleoplasm] (Dictyostelium discoideum)

phospho-Ttc5 [nucleoplasm] (Mus musculus)

phospho-Ttc5 [nucleoplasm] (Rattus norvegicus)

phospho-ttc5 [nucleoplasm] (Danio rerio)

phospho-ttc5 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 203

Coordinate

203

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 221

Coordinate

221

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_612385.2

OpenTargets

ENSG00000136319

GeneCards

Q8N0Z6

HPA

ENSG00000136319-TTC5

Ensembl

ENST00000258821, ENSP00000258821, ENSG00000136319

PRO

Q8N0Z6

Pharos - Targets

Q8N0Z6

PDB

6T59, 2XVS

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13557 CAMK2D	5	p-T287-CAMK2D [plasma membrane] (R-HSA-432794) p-T287-CAMK2D [nucleoplasm] (R-HSA-444785) p-T287-CAMK2D [endocytic vesicle membrane] (R-HSA-417002) CAMK2D [cytosol] (R-HSA-9611357) p-T287-CAMK2D [cytosol] (R-HSA-445370)	0.666	4
UniProt:Q7Z353 HDX			0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q13554-3 CAMK2B			0.556	3
UniProt:Q13555-5 CAMK2G			0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.556	3
UniProt:Q13557-8 CAMK2D			0.556	3
UniProt:Q13554 CAMK2B	5	p-T287-CAMK2B [plasma membrane] (R-HSA-432791) p-T287-CAMK2B [nucleoplasm] (R-HSA-444787) p-T287-CAMK2B [endocytic vesicle membrane] (R-HSA-417009) CAMK2B [cytosol] (R-HSA-9611360) p-T287-CAMK2B [cytosol] (R-HSA-445371)	0.556	3
UniProt:Q6NZI2 CAVIN1	2	CAVIN1 [plasma membrane] (R-HSA-9714278) PTRF [nucleoplasm] (R-HSA-74981)	0.556	3
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408)	0.483	2