Reactome | TTC5 [nucleoplasm]

TTC5 [nucleoplasm]

Stable Identifier

R-HSA-6804264

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Tetratricopeptide repeat protein 5, Stress-responsive activator of p300, Strap

Locations in the PathwayBrowser for interactor UniProt:Q13885 TUBB2A

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        ATM phosphorylates TTC5 (Homo sapiens)
        
        TTC5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N0Z6 TTC5

Gene Names

TTC5

Chain

chain:1-440

Reference Genes

BioGPS Gene:91875 TTC5

COSMIC (genes):TTC5 TTC5

CTD Gene:91875 TTC5

dbSNP Gene:91875 TTC5

ENSEMBL:ENSG00000136319 TTC5

HGNC:19274 TTC5

KEGG:hsa:91875 TTC5

Monarch:91875 TTC5

NCBI Gene:91875 TTC5

OMIM:619014 TTC5

UCSC:Q8N0Z6 TTC5

Reference Transcript

RefSeq:NM_138376.2 TTC5

Other Identifiers

11733227_a_at

11763782_a_at

1558605_PM_at

1558605_at

1558606_PM_s_at

1558606_s_at

16789899

226557_PM_at

226557_at

243007_PM_at

243007_at

3555250

3555251

3555252

3555254

3555255

3555256

3555257

3555259

3555261

3555273

3555274

3555275

3555276

3555277

3555278

3555279

3555280

3555281

3555282

3555283

3555284

3555285

3555286

3555287

3555288

3555289

3555290

3555291

57384_r_at

58419_at

60617_at

7977482

84634_r_at

91875

A_23_P88280

A_32_P96043

A_33_P3347108

GE79684

GO:0003677

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0006281

GO:0006355

GO:0006974

GO:0009267

GO:0031410

GO:0043022

GO:0043226

GO:0045944

GO:0061014

HMNXSV003014996

HMNXSV003022289

Hs.102480.0.S1_3p_at

Hs.98553.0.A1_3p_at

Hs2.405903.1.S1_3p_at

Hs2.405903.1.S1_3p_s_at

ILMN_1706455

PH_hs_0005440

PH_hs_0005682

TC14000877.hg

p4365

Participates

as an input of

ATM phosphorylates TTC5 (Homo sapiens)

Other forms of this molecule

p-S203-TTC5 [nucleoplasm]

p-S203,S221-TTC5 [nucleoplasm]

Inferred To

Ttc5 [nucleoplasm] (Mus musculus)

Ttc5 [nucleoplasm] (Rattus norvegicus)

ttc5 [nucleoplasm] (Danio rerio)

TTC5 [nucleoplasm] (Bos taurus)

TTC5 [nucleoplasm] (Caenorhabditis elegans)

TTC5 [nucleoplasm] (Canis familiaris)

TTC5 [nucleoplasm] (Dictyostelium discoideum)

TTC5 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_612385.2

OpenTargets

ENSG00000136319

ENSEMBL

ENSP00000258821, ENST00000708730, ENSP00000517308, ENST00000258821

HPA

ENSG00000136319-TTC5

PRO

Q8N0Z6

Pharos - Targets

Q8N0Z6

GlyGen

Q8N0Z6

PDB

8BPO, 7QWS, 6T59, 2XVS

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13557 CAMK2D	5	p-T287-CAMK2D [plasma membrane] (R-HSA-432794) p-T287-CAMK2D [nucleoplasm] (R-HSA-444785) p-T287-CAMK2D [endocytic vesicle membrane] (R-HSA-417002) CAMK2D [cytosol] (R-HSA-9611357) p-T287-CAMK2D [cytosol] (R-HSA-445370)	0.666	4
UniProt:Q71U36 TUBA1A	9	TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A unfolded [cytosol] (R-HSA-392767) TUBA1A folding intermediate [cytosol] (R-HSA-392805) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312)	0.615	3
UniProt:Q6NZI2 PTRF	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.556	3
UniProt:Q13554 CAMK2B	5	p-T287-CAMK2B [plasma membrane] (R-HSA-432791) p-T287-CAMK2B [nucleoplasm] (R-HSA-444787) p-T287-CAMK2B [endocytic vesicle membrane] (R-HSA-417009) CAMK2B [cytosol] (R-HSA-9611360) p-T287-CAMK2B [cytosol] (R-HSA-445371)	0.556	3
UniProt:Q13557-8 CAMK2D			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [cytosol] (R-HSA-445368) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [plasma membrane] (R-HSA-432796)	0.556	3
UniProt:Q13555-5 CAMK2G			0.556	3
UniProt:Q13554-3 CAMK2B			0.556	3
UniProt:Q7Z353 HDX			0.556	3
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.527	2
UniProt:Q13885 TUBB2A	6	TUBB2A folding intermediate [cytosol] (R-HSA-392802) TUBB2A unfolded [cytosol] (R-HSA-392776) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699)	0.527	4
UniProt:Q9BVA1 TUBB2B	6	TUBB2B folding intermediate [cytosol] (R-HSA-392796) TUBB2B unfolded [cytosol] (R-HSA-392768) Polyglycyl-TUBB2B [cytosol] (R-HSA-8867393) Polyglutamyl-TUBB2B [cytosol] (R-HSA-8867426) TUBB2B [axonemal microtubule] (R-HSA-5610432) TUBB2B [cytosol] (R-HSA-191705)	0.527	3
UniProt:O14735 CDIPT	1	CDIPT [endoplasmic reticulum membrane] (R-HSA-1498749)	0.527	2
UniProt:Q9BQE3 TUBA1C	9	AcK-TUBA1C [cytosol] (R-HSA-5618314) Ac K40 TUBA1C [axonemal microtubule] (R-HSA-5624856) TUBA1C folding intermediate [cytosol] (R-HSA-392798) TUBA1C unfolded [cytosol] (R-HSA-392772) L-isoglutamyl polyglycyl-TUBA1C [cytosol] (R-HSA-8867405) Polyglutamyl-TUBA1C [cytosol] (R-HSA-8867401) TUBA1C(1-448) [cytosol] (R-HSA-8955579) TUBA1C [axonemal microtubule] (R-HSA-5610439) TUBA1C [cytosol] (R-HSA-190590)	0.527	2
UniProt:Q8N412 STPG2			0.527	2
UniProt:Q96C00 ZBTB9			0.527	2
UniProt:Q8NFZ4 NLGN2	1	NLGN2 [plasma membrane] (R-HSA-6788639)	0.527	2
UniProt:Q13509 TUBB3	6	TUBB3 [cytosol] (R-HSA-190532) TUBB3 [axonemal microtubule] (R-HSA-5610436) Polyglutamyl-TUBB3 [cytosol] (R-HSA-8867464) Polyglycyl-TUBB3 [cytosol] (R-HSA-8867372) TUBB3 unfolded [cytosol] (R-HSA-392770) TUBB3 folding intermediate [cytosol] (R-HSA-392806)	0.527	2
UniProt:Q3ZCM7 TUBB8	3	Polyglycyl-TUBB8 [cytosol] (R-HSA-8867423) Polyglutamyl-TUBB8 [cytosol] (R-HSA-8867387) TUBB8 [cytosol] (R-HSA-6805243)	0.527	2
UniProt:Q96GM1 PLPPR2	1	LPPR2 [plasma membrane] (R-HSA-6797629)	0.527	2
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	2
UniProt:Q9NUJ3 T11L1			0.527	2

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