CHEK2 phosphorylates TTC5

Stable Identifier
R-HSA-6804266
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CHEK2 phosphorylates TTC5 (Strap), a cofactor of TP53 (p53), on serine residue S221, resulting in TTC5 stabilization through an unknown mechanism (Adams et al. 2008).

Literature References
PubMed ID Title Journal Year
18833288 ATM and Chk2 kinase target the p53 cofactor Strap

Adams, CJ, Graham, AL, Jansson, M, Coutts, AS, Edelmann, M, Smith, L, Kessler, B, La Thangue, NB

EMBO Rep. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created