Reactome: A Curated Pathway Database

ATM phosphorylates TTC5

Stable Identifier
R-HSA-6804276
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ATM phosphorylates TTC5 (Strap), a cofactor of TP53 (p53), on serine residue S203. Phosphorylation of S203 induces nuclear accumulation of TTC5, probably by interfering with the nuclear export signal at the N-terminus of TTC5 (Demonacos et al. 2004, Adams et al. 2008).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm] p-S1981,Ac-K3016-ATM [nucleoplasm] protein serine/threonine kinase activity (0004674)
Orthologous Events