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ATM phosphorylates TTC5

Stable Identifier
R-HSA-6804276
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ATM phosphorylates TTC5 (Strap), a cofactor of TP53 (p53), on serine residue S203. Phosphorylation of S203 induces nuclear accumulation of TTC5, probably by interfering with the nuclear export signal at the N-terminus of TTC5 (Demonacos et al. 2004, Adams et al. 2008).

Literature References
PubMed ID Title Journal Year
18833288 ATM and Chk2 kinase target the p53 cofactor Strap EMBO Rep. 2008
15448695 A new effector pathway links ATM kinase with the DNA damage response Nat. Cell Biol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
Physical Entity
Activity
Orthologous Events