PRMT5 methylates TP53

Stable Identifier
R-HSA-6804383
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Protein arginine methyltransferase PRMT5, recruited to TP53 (p53) by TTC5 (Strap), monomethylates TP53 on arginine residue R333 and dimethylates TP53 arginine residues R335 and R337. PRMT5-mediated methylation of TP53 modulates the affinity of TP53 for target promoters, promoting expression of cell cycle arrest genes rather than cell death genes (Jansson et al. 2008).

Literature References
PubMed ID Title Journal Year
19011621 Arginine methylation regulates the p53 response Nat. Cell Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein-arginine omega-N symmetric methyltransferase activity of p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]
Physical Entity
Activity
Orthologous Events