Reactome | PRMT5 methylates TP53

PRMT5 methylates TP53

Stable Identifier

R-HSA-6804383

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        PRMT5 methylates TP53 (Homo sapiens)

Summation

Protein arginine methyltransferase PRMT5, recruited to TP53 (p53) by TTC5 (Strap), monomethylates TP53 on arginine residue R333 and dimethylates TP53 arginine residues R335 and R337. PRMT5-mediated methylation of TP53 modulates the affinity of TP53 for target promoters, promoting expression of cell cycle arrest genes rather than cell death genes (Jansson et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
19011621	Arginine methylation regulates the p53 response	Nat. Cell Biol.	2008

Participants

Input

Output

Participant Of

hasEvent

Regulation of TP53 Activity through Methylation

Catalyst Activity

Title

protein-arginine omega-N symmetric methyltransferase activity of p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]

Physical Entity

p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]

Activity

protein-arginine omega-N symmetric methyltransferase activity (0035243)

Orthologous Events

PRMT5 methylates TP53 (Bos taurus)

PRMT5 methylates TP53 (Canis familiaris)

PRMT5 methylates TP53 (Danio rerio)

PRMT5 methylates TP53 (Mus musculus)

PRMT5 methylates TP53 (Rattus norvegicus)

PRMT5 methylates TP53 (Sus scrofa)

PRMT5 methylates TP53 (Xenopus tropicalis)