TP53 binds POU4F2

Stable Identifier
R-HSA-6804425
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TP53 binds POU4F2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

POU4F2 (BRN3B), similarly to POU4F1 (BRN3A), forms a complex with TP53 (p53). The interaction involves the POU domain of POU4F2 and the DNA binding domain of TP53. In contrast to POU4F1, binding of POU4F2 to TP53 enhances TP53-mediated transcriptional induction of pro-apoptotic targets such as BAX (Budhram-Mahadeo et al. 2006), NOXA and PUMA (Budhram-Mahadeo et al. 2014). The pro-apoptotic action of the complex of POU4F2 and TP53 may control the fate of cardiomyocytes in injured heart (Budhram-Mahadeo et al. 2014).

Literature References
PubMed ID Title Journal Year
25356872 Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults

Budhram-Mahadeo, V, Fujita, R, Bitsi, S, Sicard, P, Heads, R

Cell Death Dis 2014
17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

Budhram-Mahadeo, VS, Bowen, S, Lee, S, Perez-Sanchez, C, Ensor, E, Morris, PJ, Latchman, DS

Nucleic Acids Res. 2006
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
TP53 binds POU4F2 (Bos taurus)
TP53 binds POU4F2 (Danio rerio)
TP53 binds POU4F2 (Drosophila melanogaster)
TP53 binds POU4F2 (Mus musculus)
TP53 binds POU4F2 (Rattus norvegicus)
TP53 binds POU4F2 (Sus scrofa)
TP53 binds POU4F2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-09)
Cite Us!