Reactome | TP53 binds POU4F2

TP53 binds POU4F2

Stable Identifier

R-HSA-6804425

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 binds POU4F2 (Homo sapiens)

General

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POU4F2 (BRN3B), similarly to POU4F1 (BRN3A), forms a complex with TP53 (p53). The interaction involves the POU domain of POU4F2 and the DNA binding domain of TP53. In contrast to POU4F1, binding of POU4F2 to TP53 enhances TP53-mediated transcriptional induction of pro-apoptotic targets such as BAX (Budhram-Mahadeo et al. 2006), NOXA and PUMA (Budhram-Mahadeo et al. 2014). The pro-apoptotic action of the complex of POU4F2 and TP53 may control the fate of cardiomyocytes in injured heart (Budhram-Mahadeo et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
17145718	Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression Latchman, DS, Ensor, E, Lee, S, Perez-Sanchez, C, Morris, PJ, Bowen, S, Budhram-Mahadeo, VS	Nucleic Acids Res.	2006
25356872	Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults Fujita, R, Budhram-Mahadeo, V, Bitsi, S, Heads, R, Sicard, P	Cell Death Dis	2014