TP53 binds POU4F2

Stable Identifier
R-HSA-6804425
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SVG |   | PPTX  | SBGN
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POU4F2 (BRN3B), similarly to POU4F1 (BRN3A), forms a complex with TP53 (p53). The interaction involves the POU domain of POU4F2 and the DNA binding domain of TP53. In contrast to POU4F1, binding of POU4F2 to TP53 enhances TP53-mediated transcriptional induction of pro-apoptotic targets such as BAX (Budhram-Mahadeo et al. 2006), NOXA and PUMA (Budhram-Mahadeo et al. 2014). The pro-apoptotic action of the complex of POU4F2 and TP53 may control the fate of cardiomyocytes in injured heart (Budhram-Mahadeo et al. 2014).

Literature References
PubMed ID Title Journal Year
25356872 Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults

Budhram-Mahadeo, V, Fujita, R, Bitsi, S, Sicard, P, Heads, R

Cell Death Dis 2014
17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

Budhram-Mahadeo, VS, Bowen, S, Lee, S, Perez-Sanchez, C, Ensor, E, Morris, PJ, Latchman, DS

Nucleic Acids Res. 2006
Participants
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