RNF34 or RFFL ubiquitinates phosphorylated TP53

Stable Identifier
R-HSA-6804441
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

E3 ubiquitin ligases RNF34 (CARP1) and RFFL (CARP2) can ubiquitinate TP53 (p53) phosphorylated at the N-terminus and target it for proteasome-mediated degradation (Yang et al. 2007).

Literature References
PubMed ID Title Journal Year
17121812 CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation

Yang, W, Rozan, LM, McDonald, ER, Navaraj, A, Liu, JJ, Matthew, EM, Wang, W, Dicker, DT, El-Deiry, WS

J. Biol. Chem. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RNF34,RFFL [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed