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CITED2 [nucleoplasm]
Stable Identifier
R-HSA-6804489
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cbp/p300-interacting transactivator 2, CITE2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Regulation of gene expression by Hypoxia-inducible Factor (Homo sapiens)
Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
Activation of the TFAP2 (AP-2) family of transcription factors (Homo sapiens)
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Homo sapiens)
CITED2,CITED4,(CITED1) [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] (Homo sapiens)
CITED2,CITED4,(CITED1) [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of other transcription factors (Homo sapiens)
PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2 (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2:PITX2 Gene [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2:PITX2 Gene [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
8901575
msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation
Shioda, T
,
Fenner, MH
,
Isselbacher, KJ
Proc. Natl. Acad. Sci. U.S.A.
1996
External Reference Information
External Reference
UniProt:Q99967 CITED2
Gene Names
CITED2, MRG1
Chain
chain:1-270
Reference Genes
BioGPS Gene:10370 CITED2
COSMIC (genes):CITED2 CITED2
CTD Gene:10370 CITED2
dbSNP Gene:10370 CITED2
ENSEMBL:ENSG00000164442 CITED2
HGNC:1987 CITED2
KEGG Gene (Homo sapiens):10370 CITED2
Monarch:10370 CITED2
NCBI Gene:10370 CITED2
OMIM:602937 CITED2
UCSC:Q99967 CITED2
Reference Transcript
RefSeq:NM_006079.4 CITED2
RefSeq:NM_001168388.2 CITED2
RefSeq:NM_001168389.2 CITED2
Other Identifiers
0003170279
10370
11716210_at
11753421_a_at
17024285
207980_s_at
209357_at
2976771
2976772
2976773
2976774
2976775
2976776
2976777
2976778
2976779
2976780
2976783
2976784
2976785
2976786
33113_at
8129937
A_23_P214969
A_33_P3213374
GE54814
GO:0000003
GO:0000122
GO:0000785
GO:0001666
GO:0001889
GO:0002376
GO:0003151
GO:0003156
GO:0003674
GO:0003682
GO:0003713
GO:0003714
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006355
GO:0006950
GO:0007049
GO:0007155
GO:0007165
GO:0007275
GO:0007368
GO:0007507
GO:0007530
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0009790
GO:0010628
GO:0010629
GO:0019899
GO:0019904
GO:0022409
GO:0030154
GO:0030336
GO:0030511
GO:0032991
GO:0034405
GO:0034641
GO:0035035
GO:0035360
GO:0035802
GO:0040011
GO:0043066
GO:0043226
GO:0043627
GO:0045787
GO:0045892
GO:0045893
GO:0045944
GO:0048536
GO:0048646
GO:0048856
GO:0048870
GO:0050693
GO:0060412
GO:0060971
GO:0060972
GO:0061428
GO:0070986
GO:1900164
GO:2000020
HMNXSV003057657
ILMN_1663092
PH_hs_0004690
PH_hs_0031364
TC06002168.hg
U65093_at
g4193945_3p_at
g5174416_3p_a_at
Participates
as an output of
CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
as a component of
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
as a member of
CITED2,CITED4,(CITED1) [nucleoplasm] (Homo sapiens)
This entity regulates
Negatively
Formation of HIF:CBP:p300 complex at promoters
(Homo sapiens)
Inferred To
cited2 [nucleoplasm]
(Danio rerio)
CITED2 [nucleoplasm]
(Bos taurus)
CITED2 [nucleoplasm]
(Canis familiaris)
CITED2 [nucleoplasm]
(Gallus gallus)
CITED2 [nucleoplasm]
(Sus scrofa)
Cited2 [nucleoplasm]
(Mus musculus)
Cited2 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001161861.2
,
NP_001161860.1
,
NP_006070.2
OpenTargets
ENSG00000164442
HPA
ENSG00000164442-CITED2
GeneCards
Q99967
Ensembl
ENSP00000356623
,
ENST00000367651
,
ENSG00000164442
,
ENST00000536159
,
ENSP00000479918
,
ENSP00000442831
,
ENST00000618718
PRO
Q99967
Orphanet
19344
PDB
1R8U
,
1P4Q
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P28799 GRN
2
GRN [extracellular region]
(R-HSA-6806217)
GRN [azurophil granule lumen]
(R-HSA-6799168)
0.556
3
UniProt:P60891 PRPS1
1
PRPS1 [cytosol]
(R-HSA-73483)
0.556
3
UniProt:P41235 HNF4A
1
HNF4A [nucleoplasm]
(R-HSA-446162)
0.543
3
UniProt:Q92754 TFAP2C
3
TFAP2C [cytosol]
(R-HSA-8864579)
SUMO1-K10-TFAP2C [nucleoplasm]
(R-HSA-3234071)
TFAP2C [nucleoplasm]
(R-HSA-3234058)
0.508
2
UniProt:Q09472 EP300
5
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
SUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.508
3
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