Reactome | CITED2 [nucleoplasm]

CITED2 [nucleoplasm]

Stable Identifier

R-HSA-6804489

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cbp/p300-interacting transactivator 2, CITE2_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
8901575	msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation Shioda, T, Fenner, MH, Isselbacher, KJ	Proc. Natl. Acad. Sci. U.S.A.	1996

External Reference Information

External Reference

UniProt:Q99967 CITED2

Gene Names

CITED2, MRG1

Chain

chain:1-270

Reference Genes

BioGPS Gene:10370 CITED2

COSMIC (genes):CITED2 CITED2

CTD Gene:10370 CITED2

dbSNP Gene:10370 CITED2

ENSEMBL:ENSG00000164442 CITED2

HGNC:1987 CITED2

KEGG Gene (Homo sapiens):10370 CITED2

Monarch:10370 CITED2

NCBI Gene:10370 CITED2

OMIM:602937 CITED2

UCSC:Q99967 CITED2

Reference Transcript

Other Identifiers

0003170279

10370

11716210_at

11753421_a_at

17024285

207980_s_at

209357_at

2976771

2976772

2976773

2976774

2976775

2976776

2976777

2976778

2976779

2976780

2976783

2976784

2976785

2976786

33113_at

8129937

A_23_P214969

A_33_P3213374

GE54814

GO:0000003

GO:0000122

GO:0000785

GO:0001666

GO:0001889

GO:0002376

GO:0003151

GO:0003156

GO:0003674

GO:0003682

GO:0003713

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006355

GO:0006950

GO:0007049

GO:0007155

GO:0007165

GO:0007275

GO:0007368

GO:0007507

GO:0007530

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0009790

GO:0010628

GO:0010629

GO:0019899

GO:0019904

GO:0022409

GO:0030154

GO:0030336

GO:0030511

GO:0032991

GO:0034405

GO:0034641

GO:0035035

GO:0035360

GO:0035802

GO:0040011

GO:0043066

GO:0043226

GO:0043627

GO:0045787

GO:0045892

GO:0045893

GO:0045944

GO:0048536

GO:0048646

GO:0048856

GO:0048870

GO:0050693

GO:0060412

GO:0060971

GO:0060972

GO:0061428

GO:0070986

GO:1900164

GO:2000020

HMNXSV003057657

ILMN_1663092

PH_hs_0004690

PH_hs_0031364

TC06002168.hg

U65093_at

g4193945_3p_at

g5174416_3p_a_at

Participates

as an output of

CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)

as a component of

TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)

as a member of

CITED2,CITED4,(CITED1) [nucleoplasm] (Homo sapiens)

This entity regulates

Negatively

Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)

Inferred To

cited2 [nucleoplasm] (Danio rerio)

CITED2 [nucleoplasm] (Bos taurus)

CITED2 [nucleoplasm] (Canis familiaris)

CITED2 [nucleoplasm] (Gallus gallus)

CITED2 [nucleoplasm] (Sus scrofa)

Cited2 [nucleoplasm] (Mus musculus)

Cited2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001161861.2, NP_001161860.1, NP_006070.2

OpenTargets

ENSG00000164442

HPA

ENSG00000164442-CITED2

GeneCards

Q99967

Ensembl

ENSP00000356623, ENST00000367651, ENSG00000164442, ENST00000536159, ENSP00000479918, ENSP00000442831, ENST00000618718

PRO

Q99967

Orphanet

19344

PDB

1R8U, 1P4Q

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P28799 GRN	2	GRN [extracellular region] (R-HSA-6806217) GRN [azurophil granule lumen] (R-HSA-6799168)	0.556	3
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.556	3
UniProt:P41235 HNF4A	1	HNF4A [nucleoplasm] (R-HSA-446162)	0.543	3
UniProt:Q92754 TFAP2C	3	TFAP2C [cytosol] (R-HSA-8864579) SUMO1-K10-TFAP2C [nucleoplasm] (R-HSA-3234071) TFAP2C [nucleoplasm] (R-HSA-3234058)	0.508	2
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.508	3