Reactome: A Curated Pathway Database

INTL1 binds bacterial glycans

Stable Identifier
R-HSA-6804527
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Intelectin-1 (INTL1) is a 120-kDa secretory lectin that recognizes multiple glycan epitopes found exclusively on microbes: beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, heptoses, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (Tsuji S et al. 2001; Wesener DA et al. 2015). These glycan residues are widely distributed in bacteria, including S. pneumoniae, Proteus mirabilis, Proteus vulgaris, Yersinia pestis and K. pneumoniae (Wesener DA et al. 2015). The 1.6-A-resolution crystal structure of human INTL1 complexed with beta-Galf suggests that INTL1 binds its carbohydrate ligands bearing terminal 1,2-diols through calcium ion-dependent coordination (Wesener DA et al. 2015).

Secreted INTL1 functions as a disulfide-linked trimer (Tsuji S et al., 2001; Tsuji S et al., 2007; Wesener DA et al., 2015).

Literature References
Participants
entityOnOtherCell
Participant Of
Orthologous Events