Reactome | MED28 [nucleoplasm]

MED28 [nucleoplasm]

Stable Identifier

R-HSA-6804546

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 28, MED28_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        NS1 (1C) binds to Mediator complex (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED28 [nucleoplasm] (Homo sapiens)
        
        Mediator:NS1 [nucleoplasm] (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED28 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H204 MED28

Gene Names

MED28, EG1, FKSG20

Chain

chain:1-178

Reference Genes

BioGPS Gene:80306 MED28

COSMIC (genes):MED28 MED28

CTD Gene:80306 MED28

dbSNP Gene:80306 MED28

ENSEMBL:ENSG00000118579 MED28

HGNC:24628 MED28

KEGG:hsa:80306 MED28

Monarch:80306 MED28

NCBI Gene:80306 MED28

OMIM:610311 MED28

UCSC:Q9H204 MED28

Reference Transcript

RefSeq:NM_025205.4 MED28

Other Identifiers

11736023_a_at

11736024_at

11736025_s_at

11759175_at

16965338

218438_PM_s_at

218438_s_at

222635_PM_s_at

222635_s_at

222636_PM_at

222636_at

224416_PM_s_at

224416_s_at

227504_PM_s_at

227504_s_at

227505_PM_at

227505_at

228992_PM_at

228992_at

235105_PM_at

235105_at

235288_PM_at

235288_at

243668_PM_at

243668_at

2720182

2720183

2720184

2720185

2720186

2720187

2720188

2720189

2720190

2720191

2720192

2720193

2720194

2720195

2720196

2720197

2720198

2720199

2720201

2720203

2720205

2720207

2720208

53056_at

62776_at

64051_r_at

71686_at

77250_at

77252_at

80306

8094271

82947_at

90007_at

A_24_P932632

GE502754

GE58199

GE829447

GO:0003779

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005856

GO:0006355

GO:0008092

GO:0016020

GO:0016592

GO:0030864

GO:0032968

GO:0035019

GO:0043226

GO:0051123

GO:0051151

GO:0060261

GO:0065003

GO:0070847

HMNXSV003032150

Hs.146261.0.A1_3p_at

Hs.182585.0.S1_3p_at

Hs.18861.0.A1_3p_at

Hs.25000.0.A1_3p_at

Hs.33032.0.S2_3p_a_at

Hs.33032.2.S1_3p_at

ILMN_1749821

PH_hs_0035970

PH_hs_0038515

TC04000152.hg

TC04000153.hg

TC04000154.hg

TC04001931.hg

g13376801_3p_s_at

g13605459_3p_s_at

p12640

p26263

Participates

as a component of

Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_079481.2

OpenTargets

ENSG00000118579

ENSEMBL

ENSP00000237380, ENST00000237380

HPA

ENSG00000118579-MED28

PRO

Q9H204

Pharos - Targets

Q9H204

GlyGen

Q9H204

PDB

8GXS, 7ENJ, 8GXQ, 7NVR, 7ENA, 7ENC, 7LBM, 7EMF

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.802	10
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.8	9
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.775	7
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.744	6
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.74	6
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.725	5
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.725	6
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.691	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.676	3
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.671	7
UniProt:Q6P2C8 MED27	1	MED27 [nucleoplasm] (R-HSA-556761)	0.669	5
UniProt:O75586 MED6	1	MED6 [nucleoplasm] (R-HSA-212359)	0.669	5
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.656	3
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.643	5
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.643	5
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.643	4
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.581	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.556	3
UniProt:Q9Y2X0 MED16	1	MED16 [nucleoplasm] (R-HSA-556802)	0.527	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.527	3
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.527	2
UniProt:Q9UHV7 MED13	1	MED13 [nucleoplasm] (R-HSA-212391)	0.527	3
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.527	4
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.527	3
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.527	3
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.527	4
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.527	3
UniProt:Q96RN5 MED15	1	MED15 [nucleoplasm] (R-HSA-556827)	0.527	3
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.527	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.524	2
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.508	2