Reactome: A Curated Pathway Database

MDM2 ubiquitinates phosphorylated MDM4

Stable Identifier
R-HSA-6804724
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once MDM4 is phosphorylated by ATM and CHEK2 in response to DNA damage, MDM2 ubiquitinates MDM4 and targets it for degradation (Chen et al. 2005, Pereg et al. 2005). The presence of MDM4 stimulates auto-ubiquitination of MDM2 (Linares et al. 2003).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin protein ligase activity of p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] ubiquitin protein ligase activity (0061630)
Orthologous Events