Reactome: A Curated Pathway Database

MDM2 forms homo- or heterodimers

Stable Identifier
R-HSA-6804741
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

To efficiently function as an E3 ubiquitin ligase, MDM2 has to form dimers or higher order oligomers. MDM2 can homodimerize (Cheng et al. 2011) or heterodimerize with MDM4 (MDMX) (Sharp et al. 1999, Huang et al. 2011, Pant et al. 2011). Dimerization involves the RING domain of MDM2 and/or MDM4. Heterodimers of MDM2 and MDM4 may be particularly important during embryonic development (Pant et al. 2011).

Literature References
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Orthologous Events