Regulation of TP53 Expression

Stable Identifier
R-HSA-6804754
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Transcription of the TP53 (p53) gene is negatively regulated by the TP53 transcriptional target PRDM1 (BLIMP1), which binds to the promoter region of TP53 and probably induces repressive methylation (Yan et al. 2007).

TP53 functions as a homotetramer (Jeffrey et al. 1995, Waterman et al. 1995).

Participants
Participant Of
Orthologous Events