Regulation of TP53 Expression

Stable Identifier
R-HSA-6804754
Type
Pathway
Species
Homo sapiens
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Summation

Transcription of the TP53 (p53) gene is negatively regulated by the TP53 transcriptional target PRDM1 (BLIMP1), which binds to the promoter region of TP53 and probably induces repressive methylation (Yan et al. 2007).

TP53 functions as a homotetramer (Jeffrey et al. 1995, Waterman et al. 1995).

Literature References
PubMed ID Title Journal Year
7859740 The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding

Waterman, JL, Shenk, JL, Halazonetis, TD

EMBO J. 1995
17264218 BLIMP1 regulates cell growth through repression of p53 transcription

Yan, J, Jiang, J, Lim, CA, Wu, Q, Ng, HH, Chin, KC

Proc. Natl. Acad. Sci. U.S.A. 2007
7878469 Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

Jeffrey, PD, Gorina, S, Pavletich, NP

Science 1995
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