Reactome | IQGAP1 [secretory granule membrane]

IQGAP1 [secretory granule membrane]

Stable Identifier

R-HSA-6804803

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

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External Reference Information

External Reference

UniProt:P46940 IQGAP1

Gene Names

IQGAP1, KIAA0051

Chain

initiator methionine:1, chain:2-1657

Reference Genes

BioGPS Gene:8826 IQGAP1

COSMIC (genes):IQGAP1 IQGAP1

CTD Gene:8826 IQGAP1

dbSNP Gene:8826 IQGAP1

ENSEMBL:ENSG00000140575 IQGAP1

HGNC:6110 IQGAP1

KEGG Gene (Homo sapiens):8826 IQGAP1

Monarch:8826 IQGAP1

NCBI Gene:8826 IQGAP1

OMIM:603379 IQGAP1

UCSC:P46940 IQGAP1

Reference Transcript

RefSeq:NM_003870.3 IQGAP1

Other Identifiers

11716765_s_at

11716766_a_at

11716767_at

11752003_a_at

16804804

1825_at

200791_PM_s_at

200791_s_at

210840_PM_s_at

210840_s_at

213446_PM_s_at

213446_s_at

3608114

3608115

3608117

3608129

3608130

3608133

3608136

3608138

3608139

3608140

3608141

3608142

3608143

3608145

3608148

3608151

3608154

3608156

3608157

3608159

3608162

3608164

3608165

3608167

3608170

3608171

3608173

3608176

3608177

3608179

3608181

3608183

3608185

3608186

3608188

3608190

3608192

3608196

3608199

3608200

3608201

3608202

7986010

8826

A_14_P113294

A_24_P321919

A_33_P3417745

D29640_s_at

GE57721

GO:0000278

GO:0000902

GO:0001726

GO:0001817

GO:0003674

GO:0005078

GO:0005095

GO:0005096

GO:0005509

GO:0005515

GO:0005516

GO:0005547

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005884

GO:0005886

GO:0005911

GO:0005925

GO:0006464

GO:0007010

GO:0007049

GO:0007165

GO:0007173

GO:0007346

GO:0008092

GO:0008150

GO:0008289

GO:0008543

GO:0010761

GO:0015629

GO:0015630

GO:0016020

GO:0016328

GO:0016477

GO:0019899

GO:0019901

GO:0019903

GO:0019904

GO:0030154

GO:0030234

GO:0030424

GO:0030426

GO:0030496

GO:0030667

GO:0030674

GO:0030864

GO:0031234

GO:0031252

GO:0031267

GO:0031410

GO:0032956

GO:0032991

GO:0035305

GO:0036057

GO:0036120

GO:0036464

GO:0040007

GO:0040011

GO:0043005

GO:0043086

GO:0043087

GO:0043167

GO:0043226

GO:0043410

GO:0043539

GO:0044344

GO:0044548

GO:0045296

GO:0045860

GO:0048008

GO:0048856

GO:0048870

GO:0051015

GO:0060090

GO:0070062

GO:0071277

GO:0071364

GO:0071902

GO:0072015

GO:0120025

GO:1990138

GO:1990904

HMNXSV003003016

HMNXSV003057031

Hs.1742.2.A1_3p_a_at

ILMN_1803819

L33075_at

PH_hs_0000238

TC15000864.hg

g4506786_3p_a_at

g473930_3p_a_at

Participates

as a member of

Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)

Other forms of this molecule

IQGAP1 [cytosol]

IQGAP1 [plasma membrane]

Inferred To

Homologues of IQGAP1 [secretory granule membrane] (Dictyostelium discoideum)

Homologues of IQGAP1 [secretory granule membrane] (Schizosaccharomyces pombe)

IQGAP1 [secretory granule membrane] (Bos taurus)

IQGAP1 [secretory granule membrane] (Canis familiaris)

IQGAP1 [secretory granule membrane] (Dictyostelium discoideum)

IQGAP1 [secretory granule membrane] (Schizosaccharomyces pombe)

IQGAP1 [secretory granule membrane] (Sus scrofa)

gapA [secretory granule membrane] (Dictyostelium discoideum)

pes-7 [secretory granule membrane] (Caenorhabditis elegans)

rgaA [secretory granule membrane] (Dictyostelium discoideum)

Iqgap1 [secretory granule membrane] (Mus musculus)

Iqgap1 [secretory granule membrane] (Rattus norvegicus)

IQGAP3 [secretory granule membrane] (Gallus gallus)

rng2 [secretory granule membrane] (Schizosaccharomyces pombe)

IQG1 [secretory granule membrane] (Saccharomyces cerevisiae)

iqgap1 [secretory granule membrane] (Danio rerio)

iqgap1 [secretory granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003861.1

OpenTargets

ENSG00000140575

GeneCards

P46940

HPA

ENSG00000140575-IQGAP1

Ensembl

ENST00000268182, ENSP00000268182, ENSG00000140575

PRO

P46940

Pharos - Targets

P46940

HMDB Protein

HMDBP08471

PDB

5L0O, 2RR8, 1X0H, 3FAY, 3I6X

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.954	18
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.893	11
UniProt:P62999 RAC1			0.774	5
UniProt:P25025 CXCR2	2	CXCR2 [plasma membrane] (R-HSA-373796) CXCR2 [secretory granule membrane] (R-HSA-6804771)	0.685	12
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.626	4
UniProt:O60331-4 PIP5K1C			0.61	7
UniProt:O43707 ACTN4	3	ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [cytosol] (R-HSA-390558)	0.602	4
UniProt:O08808	4	Diaph1 [ficolin-1-rich granule membrane] (R-MMU-6801388) Diaph1 [plasma membrane] (R-MMU-6801557) Diaph1 [secretory granule membrane] (R-MMU-6801368) Diaph1 [cytosol] (R-MMU-5665970)	0.602	8
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.602	5
UniProt:P63256 ACTG			0.582	3
UniProt:P60706	6	ACTB [cytosol] (R-GGA-9715126) ACTB [extracellular region] (R-GGA-350725) ACTB [nucleoplasm] (R-GGA-3321990) ACTB [cytosol] (R-GGA-201861) ACTB [lysosomal membrane] (R-GGA-196160) ACTB [plasma membrane] (R-GGA-196016)	0.582	3
UniProt:Q99816 TSG101	1	TSG101 [endosome membrane] (R-HSA-2980549)	0.581	5
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.576	4
UniProt:Q96KN3 PKNX2			0.556	3
UniProt:P52954 LBX1			0.556	3
UniProt:Q12905 ILF2	4	ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001)	0.556	3
UniProt:A8MW99 MEI4			0.556	3
UniProt:P32243-2 OTX2			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.544	4
UniProt:P60660-2 MYL6			0.527	2
UniProt:Q13011 ECH1	2	ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.527	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.527	3
UniProt:O00592 PODXL			0.518	4
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.518	4
UniProt:Q96QZ7 MAGI1			0.518	4
UniProt:Q9NP85 NPHS2	1	NPHS2 [plasma membrane] (R-HSA-373633)	0.518	4
UniProt:O60500 NPHS1	2	p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (R-HSA-373636) NPHS1 [plasma membrane] (R-HSA-8981500)	0.518	5
UniProt:P62158 CALM			0.508	2
UniProt:Q05823 RNASEL	2	RNASEL [cytosol] (R-HSA-1015684) RNASEL [mitochondrial matrix] (R-HSA-5223312)	0.499	2
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.491	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.463	3
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
UniProt:Q00005 2ABB			0.462	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.462	2

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