Reactome | IQGAP1 [secretory granule membrane]

IQGAP1 [secretory granule membrane]

Stable Identifier

R-HSA-6804803

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

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External Reference Information

External Reference

UniProt:P46940 IQGAP1

Gene Names

IQGAP1, KIAA0051

Chain

initiator methionine:1, chain:2-1657

Reference Genes

BioGPS Gene:8826 IQGAP1

COSMIC (genes):IQGAP1 IQGAP1

CTD Gene:8826 IQGAP1

dbSNP Gene:8826 IQGAP1

ENSEMBL:ENSG00000140575 IQGAP1

ENSEMBL_homo_sapiens_GENE:ENSG00000140575 IQGAP1

HGNC:6110 IQGAP1

KEGG Gene (Homo sapiens):8826 IQGAP1

Monarch:8826 IQGAP1

NCBI Gene:8826 IQGAP1

OMIM:603379 IQGAP1

UCSC:P46940 IQGAP1

Reference Transcript

RefSeq:NM_003870.3 IQGAP1

Other Identifiers

11716765_s_at

11716766_a_at

11716767_at

11752003_a_at

13302

14055

16804804

1825_at

1X0H

200791_s_at

210840_s_at

213446_s_at

2RR8

3608114

3608115

3608117

3608129

3608130

3608133

3608136

3608138

3608139

3608140

3608141

3608142

3608143

3608145

3608148

3608151

3608154

3608156

3608157

3608159

3608162

3608164

3608165

3608167

3608170

3608171

3608173

3608176

3608177

3608179

3608181

3608183

3608185

3608186

3608188

3608190

3608192

3608196

3608199

3608200

3608201

3608202

3FAY

3I6X

5L0O

7986010

8826

A0A024RC65

A0A087WWP1

A0A0J9YXZ5

A_24_P321919

AAA59187

AAI51835

BAA06123

BC151834

CAB013302

CCDS10362

CH471101

D29640

D29640_s_at

EAX02102

EAX02103

ENSG00000140575

ENSP00000268182

ENST00000268182

ENST00000268182.9

EntrezGene:8826

g4506786_3p_a_at

g473930_3p_a_at

GE57721

GO:0001726

GO:0001817

GO:0002376

GO:0003674

GO:0005095

GO:0005096

GO:0005198

GO:0005509

GO:0005515

GO:0005516

GO:0005547

GO:0005575

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005884

GO:0005886

GO:0005911

GO:0005925

GO:0006810

GO:0007165

GO:0007173

GO:0007346

GO:0008150

GO:0008289

GO:0008543

GO:0015629

GO:0015630

GO:0016020

GO:0016032

GO:0016192

GO:0016328

GO:0016477

GO:0017048

GO:0019899

GO:0019901

GO:0019903

GO:0019904

GO:0030234

GO:0030424

GO:0030426

GO:0030496

GO:0030667

GO:0031234

GO:0031252

GO:0031267

GO:0032947

GO:0032991

GO:0034260

GO:0035305

GO:0036057

GO:0036120

GO:0036464

GO:0040007

GO:0040011

GO:0043005

GO:0043087

GO:0043167

GO:0043226

GO:0043312

GO:0043406

GO:0043539

GO:0043547

GO:0044344

GO:0044403

GO:0044548

GO:0044877

GO:0045121

GO:0045296

GO:0045860

GO:0048008

GO:0048365

GO:0048856

GO:0048870

GO:0051019

GO:0051894

GO:0070062

GO:0071277

GO:0071364

GO:0072015

GO:1900006

GO:1900086

GO:1903829

GO:1904754

GO:1990138

GO:1990776

GO:1990904

H0YKA5

H0YLE8

HGNC:6110

HPA014055

Hs.1742.2.A1_3p_a_at

ILMN_1803819

IPR000048

IPR000593

IPR001202

IPR001715

IPR001936

IPR008936

IPR023152

IPR027417

IPR036872

IQGAP1

IQGAP1-201

L33075

L33075_at

MIM:603379

NM_003870

NP_003861

PF00307

PF00612

PF00616

PF03836

PH_hs_0000238

SM00015

SM00033

SM00323

SM00456

TC15000864.hg

UPI000012D863

Participant Of

hasMember

Secretory granule membrane proteins [secretory granule membrane]

Other forms of this molecule

IQGAP1 [cytosol]

IQGAP1 [plasma membrane]

Inferred To

Homologues of IQGAP1 [secretory granule membrane] (Dictyostelium discoideum)

Homologues of IQGAP1 [secretory granule membrane] (Schizosaccharomyces pombe)

IQGAP1 [secretory granule membrane] (Bos taurus)

IQGAP1 [secretory granule membrane] (Caenorhabditis elegans)

IQGAP1 [secretory granule membrane] (Canis familiaris)

IQGAP1 [secretory granule membrane] (Danio rerio)

IQGAP1 [secretory granule membrane] (Dictyostelium discoideum)

IQGAP1 [secretory granule membrane] (Gallus gallus)

IQGAP1 [secretory granule membrane] (Mus musculus)

IQGAP1 [secretory granule membrane] (Rattus norvegicus)

IQGAP1 [secretory granule membrane] (Saccharomyces cerevisiae)

IQGAP1 [secretory granule membrane] (Schizosaccharomyces pombe)

IQGAP1 [secretory granule membrane] (Sus scrofa)

IQGAP1 [secretory granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003861.1

OpenTargets

ENSG00000140575

GeneCards

P46940

PRO

P46940

HMDB Protein

HMDBP08471

PDB

3I6X, 2RR8, 3FAY, 1X0H, 5L0O

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545)	0.886	11
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.78	5
UniProt:P62999 RAC1			0.774	5
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.626	4
UniProt:O60331-4 PIP5K1C			0.61	7
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.602	5
UniProt:O08808	4	DIAPH1 [plasma membrane] (R-MMU-6801557) DIAPH1 [secretory granule membrane] (R-MMU-6801368) DIAPH1 [ficolin-1-rich granule membrane] (R-MMU-6801388) DIAPH1 [cytosol] (R-MMU-5665970)	0.602	8
UniProt:O43707 ACTN4	3	ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [cytosol] (R-HSA-390558)	0.602	4
UniProt:P60706	4	ACTB(1-375) [nucleoplasm] (R-GGA-3321990) ACTB(1-375) [lysosomal membrane] (R-GGA-196160) ACTB(1-375) [cytosol] (R-GGA-201861) ACTB(1-375) [plasma membrane] (R-GGA-196016)	0.582	3
UniProt:P63256 ACTG			0.582	3
UniProt:Q99816 TSG101	1	TSG101 [endosome membrane] (R-HSA-2980549)	0.581	5
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723)	0.576	4
UniProt:O00592 PODXL			0.556	4
UniProt:Q96QZ7 MAGI1			0.556	4
UniProt:Q9NP85 NPHS2	1	NPHS2 [plasma membrane] (R-HSA-373633)	0.556	4
UniProt:O60500 NPHS1	2	NPHS1 [plasma membrane] (R-HSA-8981500) p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (R-HSA-373636)	0.556	5
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.556	4
UniProt:P15056 BRAF	32	p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) D594N BRAF [cytosol] (R-HSA-6802299) G596R BRAF [cytosol] (R-HSA-6802385) D594V BRAF [cytosol] (R-HSA-6802305) G466E BRAF [cytosol] (R-HSA-6802374) D594G BRAF [cytosol] (R-HSA-6802295) F595L BRAF [cytosol] (R-HSA-6802316) L597V BRAF [cytosol] (R-HSA-6802397) G464E BRAF [cytosol] (R-HSA-6802369) E586K BRAF [cytosol] (R-HSA-6802308) V600K BRAF [cytosol] (R-HSA-6802502) p-L597V BRAF [plasma membrane] (R-HSA-8936647) p-G464E BRAF [plasma membrane] (R-HSA-8936645) p-F595L BRAF [plasma membrane] (R-HSA-8936641) p-E586K BRAF [plasma membrane] (R-HSA-8936639) p-V600K BRAF [plasma membrane] (R-HSA-8936651) BRAF 599dupT [cytosol] (R-HSA-6802281) G469A BRAF [cytosol] (R-HSA-6802381) V600E BRAF [cytosol] (R-HSA-6802498) V600E BRAF V169_M438del [cytosol] (R-HSA-6802489) V600E BRAF V47_D380del [cytosol] (R-HSA-6802491) V600E BRAF V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF [cytosol] (R-HSA-167224) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.544	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P62158 CALM			0.508	2
UniProt:Q05823 RNASEL	2	RNASEL [cytosol] (R-HSA-1015684) RNASEL [mitochondrial matrix] (R-HSA-5223312)	0.499	2
UniProt:P60709 ACTB	5	ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [plasma membrane] (R-HSA-196016) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160)	0.491	2
UniProt:Q96KN3 PKNX2			0.488	2
UniProt:P52954 LBX1			0.488	2
UniProt:Q12905 ILF2	4	ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [specific granule lumen] (R-HSA-6799611)	0.488	2
UniProt:A8MW99 MEI4			0.488	2
UniProt:P32243-2 OTX2			0.488	2
UniProt:Q6FHY5 Q6FHY5			0.488	2
UniProt:P35222 CTNNB1	24	CTNNB1 S45P [cytosol] (R-HSA-4791272) CTNNB1 S45F [cytosol] (R-HSA-4791268) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.463	3
UniProt:Q00005 2ABB			0.462	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2