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What is Reactome ?
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IQGAP1 [secretory granule membrane]
Stable Identifier
R-HSA-6804803
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule membrane
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
IQGAP1 [secretory granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46940 IQGAP1
Gene Names
IQGAP1, KIAA0051
Chain
initiator methionine:1, chain:2-1657
Reference Genes
BioGPS Gene:8826 IQGAP1
COSMIC (genes):IQGAP1 IQGAP1
CTD Gene:8826 IQGAP1
dbSNP Gene:8826 IQGAP1
ENSEMBL:ENSG00000140575 IQGAP1
HGNC:6110 IQGAP1
KEGG Gene (Homo sapiens):8826 IQGAP1
Monarch:8826 IQGAP1
NCBI Gene:8826 IQGAP1
OMIM:603379 IQGAP1
UCSC:P46940 IQGAP1
Reference Transcript
RefSeq:NM_003870.3 IQGAP1
Other Identifiers
11716765_s_at
11716766_a_at
11716767_at
11752003_a_at
16804804
1825_at
200791_s_at
210840_s_at
213446_s_at
3608114
3608115
3608117
3608129
3608130
3608133
3608136
3608138
3608139
3608140
3608141
3608142
3608143
3608145
3608148
3608151
3608154
3608156
3608157
3608159
3608162
3608164
3608165
3608167
3608170
3608171
3608173
3608176
3608177
3608179
3608181
3608183
3608185
3608186
3608188
3608190
3608192
3608196
3608199
3608200
3608201
3608202
7986010
8826
A_14_P113294
A_24_P321919
A_33_P3417745
D29640_s_at
GE57721
GO:0000278
GO:0000902
GO:0001726
GO:0001817
GO:0002376
GO:0003674
GO:0005078
GO:0005095
GO:0005096
GO:0005509
GO:0005515
GO:0005516
GO:0005547
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005884
GO:0005886
GO:0005911
GO:0005925
GO:0006464
GO:0006810
GO:0007049
GO:0007155
GO:0007165
GO:0007173
GO:0007346
GO:0008150
GO:0008289
GO:0008543
GO:0010761
GO:0015629
GO:0015630
GO:0016020
GO:0016032
GO:0016192
GO:0016328
GO:0016477
GO:0017048
GO:0019899
GO:0019901
GO:0019903
GO:0019904
GO:0022607
GO:0030154
GO:0030234
GO:0030424
GO:0030426
GO:0030496
GO:0030667
GO:0030674
GO:0031234
GO:0031252
GO:0031267
GO:0031410
GO:0032991
GO:0034260
GO:0034330
GO:0035305
GO:0036057
GO:0036120
GO:0036464
GO:0040007
GO:0040011
GO:0043005
GO:0043087
GO:0043167
GO:0043226
GO:0043312
GO:0043406
GO:0043410
GO:0043539
GO:0043547
GO:0044344
GO:0044403
GO:0044548
GO:0044877
GO:0045121
GO:0045296
GO:0045860
GO:0048008
GO:0048365
GO:0048856
GO:0048870
GO:0051019
GO:0051894
GO:0060090
GO:0070062
GO:0071277
GO:0071364
GO:0072015
GO:1900006
GO:1900086
GO:1903829
GO:1904754
GO:1990138
GO:1990776
GO:1990904
Hs.1742.2.A1_3p_a_at
ILMN_1803819
L33075_at
PH_hs_0000238
TC15000864.hg
g4506786_3p_a_at
g473930_3p_a_at
Participant Of
hasMember
Secretory granule membrane proteins [secretory granule membrane]
Other forms of this molecule
IQGAP1 [cytosol]
IQGAP1 [plasma membrane]
Inferred To
Homologues of IQGAP1 [secretory granule membrane] (Dictyostelium discoideum)
Homologues of IQGAP1 [secretory granule membrane] (Schizosaccharomyces pombe)
IQGAP1 [secretory granule membrane] (Bos taurus)
IQGAP1 [secretory granule membrane] (Canis familiaris)
IQGAP1 [secretory granule membrane] (Dictyostelium discoideum)
IQGAP1 [secretory granule membrane] (Gallus gallus)
IQGAP1 [secretory granule membrane] (Schizosaccharomyces pombe)
IQGAP1 [secretory granule membrane] (Sus scrofa)
gapA [secretory granule membrane] (Dictyostelium discoideum)
pes-7 [secretory granule membrane] (Caenorhabditis elegans)
rgaA [secretory granule membrane] (Dictyostelium discoideum)
Iqgap1 [secretory granule membrane] (Mus musculus)
Iqgap1 [secretory granule membrane] (Rattus norvegicus)
rng2 [secretory granule membrane] (Schizosaccharomyces pombe)
IQG1 [secretory granule membrane] (Saccharomyces cerevisiae)
iqgap1 [secretory granule membrane] (Danio rerio)
iqgap1 [secretory granule membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_003861.1
OpenTargets
ENSG00000140575
HPA
ENSG00000140575-IQGAP1
GeneCards
P46940
Ensembl
ENSP00000268182
,
ENSG00000140575
,
ENST00000268182
PRO
P46940
PDB
3FAY
,
3I6X
,
5L0O
,
1X0H
,
2RR8
HMDB Protein
HMDBP08471
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [plasma membrane]
(R-HSA-449545)
0.954
18
UniProt:P63000 RAC1
6
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.893
11
UniProt:P62999 RAC1
0.774
5
UniProt:P25025 CXCR2
2
CXCR2 [secretory granule membrane]
(R-HSA-6804771)
CXCR2 [plasma membrane]
(R-HSA-373796)
0.685
12
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.626
4
UniProt:O60331-4 PIP5K1C
0.61
7
UniProt:P04626 ERBB2
117
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665656)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
p-Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 L755W [plasma membrane]
(R-HSA-9654193)
p-Y-ERBB2 T733I [plasma membrane]
(R-HSA-9654610)
p-Y-ERBB2 H878R [plasma membrane]
(R-HSA-9654835)
p-Y-ERBB2 L869R [plasma membrane]
(R-HSA-9654730)
p-Y-ERBB2 G776S [plasma membrane]
(R-HSA-9664608)
p-Y-ERBB2 L869Q [plasma membrane]
(R-HSA-9654732)
p-Y-ERBB2 G776L [plasma membrane]
(R-HSA-9664600)
p-Y-ERBB2 G776V [plasma membrane]
(R-HSA-9664602)
p-Y-ERBB2 G776C [plasma membrane]
(R-HSA-9664611)
ERBB2 D769Y [plasma membrane]
(R-HSA-9646620)
ERBB2 L755P [plasma membrane]
(R-HSA-9646494)
ERBB2 V842I [plasma membrane]
(R-HSA-9646703)
ERBB2 H878Y [plasma membrane]
(R-HSA-9646824)
ERBB2 T798M [plasma membrane]
(R-HSA-9646825)
ERBB2 D769H [plasma membrane]
(R-HSA-9646617)
ERBB2 T862A [plasma membrane]
(R-HSA-9649434)
ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665621)
ERBB2 L755S [plasma membrane]
(R-HSA-9646423)
ERBB2 I767M [plasma membrane]
(R-HSA-9646737)
ERBB2 V777L [plasma membrane]
(R-HSA-9646579)
ERBB2 D769N [plasma membrane]
(R-HSA-9646636)
ERBB2 T733I [plasma membrane]
(R-HSA-9646765)
ERBB2 V777M [plasma membrane]
(R-HSA-9646591)
ERBB2 V777E [plasma membrane]
(R-HSA-9646586)
ERBB2 L755W [plasma membrane]
(R-HSA-9646516)
ERBB2 L755M [plasma membrane]
(R-HSA-9646517)
ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665622)
ERBB2 H878R [plasma membrane]
(R-HSA-9646822)
ERBB2 V842E [plasma membrane]
(R-HSA-9646710)
ERBB2 T798I [plasma membrane]
(R-HSA-9646823)
ERBB2 R896C [plasma membrane]
(R-HSA-9646714)
ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9646667)
ERBB2 R896H [plasma membrane]
(R-HSA-9646728)
ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665625)
ERBB2 G776S [plasma membrane]
(R-HSA-9664463)
ERBB2 L869R [plasma membrane]
(R-HSA-9646827)
ERBB2 L869Q [plasma membrane]
(R-HSA-9646828)
ERBB2 G776C [plasma membrane]
(R-HSA-9664457)
ERBB2 G776L [plasma membrane]
(R-HSA-9664454)
ERBB2 G776V [plasma membrane]
(R-HSA-9664450)
p-6Y-ERBB2 V777L [plasma membrane]
(R-HSA-9647214)
p-6Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9647215)
ERBB2 L755_T759del [plasma membrane]
(R-HSA-9663599)
p-6Y-ERBB2 R896C [plasma membrane]
(R-HSA-9647208)
p-6Y-ERBB2 V842I [plasma membrane]
(R-HSA-9647209)
p-6Y-ERBB2 I767M [plasma membrane]
(R-HSA-9647211)
p-6Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654692)
p-6Y-ERBB2 D769H [plasma membrane]
(R-HSA-9647200)
p-6Y-ERBB2 T798I [plasma membrane]
(R-HSA-9647202)
p-6Y-ERBB2 L755P [plasma membrane]
(R-HSA-9647196)
p-6Y-ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9647198)
p-6Y-ERBB2 L755S [plasma membrane]
(R-HSA-9647216)
p-6Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665650)
p-6Y-ERBB2 T798M [plasma membrane]
(R-HSA-9647218)
p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665644)
p-6Y-ERBB2 D769Y [plasma membrane]
(R-HSA-9647199)
p-6Y-ERBB2 V777E [plasma membrane]
(R-HSA-9647210)
p-6Y-ERBB2 T733I [plasma membrane]
(R-HSA-9647195)
p-6Y-ERBB2 L755M [plasma membrane]
(R-HSA-9647204)
p-6Y-ERBB2 V777M [plasma membrane]
(R-HSA-9647205)
p-6Y-ERBB2 V842E [plasma membrane]
(R-HSA-9647206)
p-6Y-ERBB2 D769N [plasma membrane]
(R-HSA-9647207)
p-6Y-ERBB2 R896H [plasma membrane]
(R-HSA-9647217)
p-6Y-ERBB2 L755W [plasma membrane]
(R-HSA-9647201)
p-6Y-ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665634)
p-6Y-ERBB2 H878R [plasma membrane]
(R-HSA-9647203)
p-6Y-ERBB2 E693K [plasma membrane]
(R-HSA-9665871)
p-6Y-ERBB2 R677L [plasma membrane]
(R-HSA-9665864)
p-6Y-ERBB2 Q709L [plasma membrane]
(R-HSA-9665865)
p-6Y-ERBB2 G660D [plasma membrane]
(R-HSA-9665866)
p-6Y-ERBB2 G660R [plasma membrane]
(R-HSA-9665878)
p-6Y-ERBB2 V659K [plasma membrane]
(R-HSA-9665863)
p-6Y-ERBB2 V659E [plasma membrane]
(R-HSA-9665874)
ERBB2 R678Q [plasma membrane]
(R-HSA-9665756)
ERBB2 S653C [plasma membrane]
(R-HSA-9665754)
ERBB2 R677L [plasma membrane]
(R-HSA-9665759)
ERBB2 G660R [plasma membrane]
(R-HSA-9665768)
ERBB2 V659E [plasma membrane]
(R-HSA-9665752)
ERBB2 G660D [plasma membrane]
(R-HSA-9665753)
ERBB2 V659K [plasma membrane]
(R-HSA-9665769)
ERBB2 Q709L [plasma membrane]
(R-HSA-9665770)
ERBB2 E693K [plasma membrane]
(R-HSA-9665761)
p-6Y-ERBB2 R678Q [plasma membrane]
(R-HSA-9665876)
p-6Y-ERBB2 S653C [plasma membrane]
(R-HSA-9665875)
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863841)
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863836)
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864084)
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864090)
p-Y877-ERBB2 [plasma membrane]
(R-HSA-1810438)
ERBB2 [plasma membrane]
(R-HSA-372889)
p-6Y-ERBB2 [plasma membrane]
(R-HSA-1963569)
p-6Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864081)
p-Y-ERBB2 [plasma membrane]
(R-HSA-1678589)
p-Y,Y877-ERBB2 [plasma membrane]
(R-HSA-1810446)
p-7Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864079)
p-7Y-ERBB2 [plasma membrane]
(R-HSA-1248698)
0.602
5
UniProt:O08808
4
Diaph1 [plasma membrane]
(R-MMU-6801557)
Diaph1 [ficolin-1-rich granule membrane]
(R-MMU-6801388)
Diaph1 [secretory granule membrane]
(R-MMU-6801368)
Diaph1 [cytosol]
(R-MMU-5665970)
0.602
8
UniProt:O43707 ACTN4
3
ACTN4 [platelet alpha granule lumen]
(R-HSA-198240)
ACTN4 [extracellular region]
(R-HSA-349729)
ACTN4 [cytosol]
(R-HSA-390558)
0.602
4
UniProt:P60706
4
ACTB(1-375) [nucleoplasm]
(R-GGA-3321990)
ACTB(1-375) [lysosomal membrane]
(R-GGA-196160)
ACTB(1-375) [cytosol]
(R-GGA-201861)
ACTB(1-375) [plasma membrane]
(R-GGA-196016)
0.582
3
UniProt:P63256 ACTG
0.582
3
UniProt:Q99816 TSG101
1
TSG101 [endosome membrane]
(R-HSA-2980549)
0.581
5
UniProt:P56945 BCAR1
4
p-Y12-BCAR1 [cytosol]
(R-HSA-5218739)
p-Y-BCAR1 [cytosol]
(R-HSA-372645)
p-Y165,Y664-BCAR1 [cytosol]
(R-HSA-8848723)
BCAR1 [cytosol]
(R-HSA-201625)
0.576
4
UniProt:O00592 PODXL
0.556
4
UniProt:Q96KN3 PKNX2
0.556
3
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.556
4
UniProt:Q96QZ7 MAGI1
0.556
4
UniProt:Q9NP85 NPHS2
1
NPHS2 [plasma membrane]
(R-HSA-373633)
0.556
4
UniProt:P52954 LBX1
0.556
3
UniProt:Q12905 ILF2
4
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
ILF2 [specific granule lumen]
(R-HSA-6799611)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
0.556
3
UniProt:A8MW99 MEI4
0.556
3
UniProt:P32243-2 OTX2
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q96N21 AP4AT
0.556
3
UniProt:O60500 NPHS1
2
NPHS1 [plasma membrane]
(R-HSA-8981500)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane]
(R-HSA-373636)
0.556
5
UniProt:P15056 BRAF
68
p-BRAF-MACF1 fusion [cytosol]
(R-HSA-6802536)
BRAF-MACF1fusion [cytosol]
(R-HSA-6802402)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
BRAF G469R [cytosol]
(R-HSA-9648621)
BRAF L597R [cytosol]
(R-HSA-9648617)
BRAF G469E [cytosol]
(R-HSA-9648618)
BRAF L597Q [cytosol]
(R-HSA-9648619)
BRAF G466A [cytosol]
(R-HSA-9648613)
BRAF G466V [cytosol]
(R-HSA-9648838)
BRAF N581S [cytosol]
(R-HSA-9648850)
BRAF G464V [cytosol]
(R-HSA-9648611)
p-BRAF L597V [plasma membrane]
(R-HSA-8936647)
p-BRAF L505H [plasma membrane]
(R-HSA-9648862)
p-BRAF G464E [plasma membrane]
(R-HSA-8936645)
p-BRAF F595L [plasma membrane]
(R-HSA-8936641)
p-BRAF A246P [plasma membrane]
(R-HSA-9651188)
p-BRAF E586K [plasma membrane]
(R-HSA-8936639)
p-BRAF N581D [plasma membrane]
(R-HSA-9651191)
p-BRAF V600K [plasma membrane]
(R-HSA-8936651)
p-BRAF G464V [plasma membrane]
(R-HSA-9648633)
p-BRAF T244P [plasma membrane]
(R-HSA-9651194)
p-BRAF G469E [plasma membrane]
(R-HSA-9648634)
p-BRAF G466V [plasma membrane]
(R-HSA-9648859)
p-BRAF G469V [plasma membrane]
(R-HSA-9648628)
p-BRAF G466A [plasma membrane]
(R-HSA-9648629)
p-BRAF L597Q [plasma membrane]
(R-HSA-9648630)
p-BRAF L597R [plasma membrane]
(R-HSA-9648631)
p-BRAF N581S [plasma membrane]
(R-HSA-9648866)
p-BRAF G469R [plasma membrane]
(R-HSA-9648627)
BRAF 599dupT [cytosol]
(R-HSA-6802281)
BRAF G534R [cytosol]
(R-HSA-9651134)
BRAF S467A [cytosol]
(R-HSA-9651161)
BRAF K601N [cytosol]
(R-HSA-9648857)
BRAF G469A [cytosol]
(R-HSA-6802381)
BRAF L485F [cytosol]
(R-HSA-9651147)
BRAF Q257R [cytosol]
(R-HSA-9651157)
BRAF K499E [cytosol]
(R-HSA-9651142)
BRAF V600E [cytosol]
(R-HSA-6802498)
BRAF K601E [cytosol]
(R-HSA-9648833)
BRAF V600E V169_M438del [cytosol]
(R-HSA-6802489)
BRAF V600E V47_D380del [cytosol]
(R-HSA-6802491)
BRAF V600E V47_M438del [cytosol]
(R-HSA-6802495)
V600E BRAF V169_D380del [cytosol]
(R-HSA-6802486)
p-S445,S729-BRAF [plasma membrane]
(R-HSA-8933622)
p-S,T-BRAF [cytosol]
(R-HSA-169856)
BRAF [cytosol]
(R-HSA-167224)
hyperphosphorylated BRAF [plasma membrane]
(R-HSA-5675199)
p-S365,S445,S729 BRAF [cytosol]
(R-HSA-5672667)
p-S445,T599,S602,S729 BRAF [plasma membrane]
(R-HSA-5672679)
p-S445,S729-BRAF [cytosol]
(R-HSA-5672673)
p-S445,T599,S602,S729 BRAF [cytosol]
(R-HSA-5672676)
0.544
4
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P60660-2 MYL6
0.527
2
UniProt:Q13011 ECH1
2
ECH1(1-328) [cytosol]
(R-HSA-9033152)
ECH1(1-328) [peroxisomal matrix]
(R-HSA-9033140)
0.527
2
UniProt:Q16539 MAPK14
7
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
MAPK14 [nucleoplasm]
(R-HSA-446223)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.527
3
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:P0DP23 CALM1
5
Me3K115-CALM1 [cytosol]
(R-HSA-9016706)
CALM1 [extracellular region]
(R-HSA-9016841)
CALM1 [plasma membrane]
(R-HSA-9016884)
CALM1 [nucleoplasm]
(R-HSA-9016871)
CALM1 [cytosol]
(R-HSA-9016707)
0.508
2
UniProt:Q05823 RNASEL
2
RNASEL [cytosol]
(R-HSA-1015684)
RNASEL [mitochondrial matrix]
(R-HSA-5223312)
0.499
2
UniProt:P60709 ACTB
5
ACTB(1-375) [cytosol]
(R-HSA-201861)
ACTB(1-375) [plasma membrane]
(R-HSA-196016)
ACTB(1-375) [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB(1-375) [lysosomal membrane]
(R-HSA-196160)
0.491
2
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.463
3
UniProt:Q00005 2ABB
0.462
2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]
7
PI(3,5)P2 [plasma membrane]
(R-ALL-1806224)
PI(3,5)P2 [phagophore assembly site membrane]
(R-ALL-5692959)
PI(3,5)P2 [Golgi membrane]
(R-ALL-1806290)
PI(3,5)P2 [early endosome membrane]
(R-ALL-1806205)
PI(3,5)P2 [late endosome membrane]
(R-ALL-1806289)
PI(3,5)P2 [endoplasmic reticulum membrane]
(R-ALL-6809774)
PI(3,5)P2 [lysosomal membrane]
(R-ALL-5334668)
0.462
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.462
2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]
6
PI(4,5)P2 [Golgi membrane]
(R-ALL-1806165)
PI(4,5)P2 [plasma membrane]
(R-ALL-179856)
PI(4,5)P2 [endoplasmic reticulum membrane]
(R-ALL-2023856)
PI(4,5)P2 [nucleoplasm]
(R-ALL-6810412)
PI(4,5)P2 [cytoplasmic vesicle membrane]
(R-ALL-8874467)
PI(4,5)P2 [early endosome membrane]
(R-ALL-8849966)
0.462
2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]
6
PI(3,4,5)P3 [endocytic vesicle membrane]
(R-ALL-917725)
PIP3 [plasma membrane]
(R-ALL-38117)
PI(3,4,5)P3 [endosome membrane]
(R-ALL-917716)
PI(3,4,5)P3 [early endosome membrane]
(R-ALL-8849955)
PI(3,4,5)P3 [cytoplasmic vesicle membrane]
(R-ALL-8874468)
PI(3,4,5)P3 [plasma membrane]
(R-ALL-179838)
0.462
2
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![IQGAP1 [secretory granule membrane] icon](/icon/R-ICO-012909.svg){kind=icon}
