Reactome: A Curated Pathway Database

MDM2 homodimers auto-ubiquitinate

Stable Identifier
R-HSA-6804942
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MDM2 undergoes auto-ubiquitination (Fang et al. 2000). Formation of homodimers may not be necessary for auto-ubiquitination (Cheng et al. 2011).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer [nucleoplasm] p-S166,S188-MDM2 dimer [nucleoplasm] ubiquitin protein ligase activity (0061630)
Orthologous Events