Reactome: A Curated Pathway Database

ATM phosphorylates MDM2

Stable Identifier
R-HSA-6804955
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ATM phosphorylates MDM2 on three serine residues (S386, S395, S407) and one threonine residue (T419) in vicinity to the RING domain. ATM-mediated phosphorylation of MDM2 in response to DNA damage (DNA double strand breaks) prevents MDM2 dimerization, binding of TP53 (p53) and MDM2-mediated ubiquitination of TP53 (Cheng et al. 2009, Cheng et al. 2011).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm] p-S1981,Ac-K3016-ATM [nucleoplasm] protein serine/threonine kinase activity (0004674)
Orthologous Events