ATM phosphorylates MDM2

Stable Identifier
R-HSA-6804955
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ATM phosphorylates MDM2 on three serine residues (S386, S395, S407) and one threonine residue (T419) in vicinity to the RING domain. ATM-mediated phosphorylation of MDM2 in response to DNA damage (DNA double strand breaks) prevents MDM2 dimerization, binding of TP53 (p53) and MDM2-mediated ubiquitination of TP53 (Cheng et al. 2009, Cheng et al. 2011).

Literature References
PubMed ID Title Journal Year
19816404 ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

Cheng, Q, Chen, L, Li, Z, Lane, WS, Chen, J

EMBO J. 2009
21986495 Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage

Cheng, Q, Cross, B, Li, B, Chen, L, Li, Z, Chen, J

Mol. Cell. Biol. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed