Reactome | RHOA [ficolin-1-rich granule membrane]

RHOA [ficolin-1-rich granule membrane]

Stable Identifier

R-HSA-6804971

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule membrane

Synonyms

RhoA, Transforming protein RhoA, RHOA_HUMAN

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External Reference Information

External Reference

UniProt:P61586 RHOA

Gene Names

RHOA, ARH12, ARHA, RHO12

Chain

chain:1-190, propeptide:191-193

Reference Genes

BioGPS Gene:387 RHOA

COSMIC (genes):RHOA RHOA

CTD Gene:387 RHOA

dbSNP Gene:387 RHOA

ENSEMBL:ENSG00000067560 RHOA

HGNC:667 RHOA

KEGG Gene (Homo sapiens):387 RHOA

Monarch:387 RHOA

NCBI Gene:387 RHOA

OMIM:165390 RHOA

UCSC:P61586 RHOA

Reference Transcript

Other Identifiers

0005220088

11743726_s_at

11753410_a_at

11754043_a_at

11757012_x_at

1394_at

1555814_a_at

16954055

18670076

18670077

18670078

18670080

18670081

200059_PM_s_at

200059_s_at

2674238

2674239

2674240

2674241

2674243

2674244

2674245

2674246

2674247

2674248

2674249

2674252

2674253

2674255

2674258

2674265

2674266

2965039

37309_at

387

4000064

7892846

7893424

7893647

7893815

7894083

7895551

7895657

7896138

7896438

8087409

A_23_P69491

A_23_P69493

A_24_P174550

GE79565

GO:0000166

GO:0000278

GO:0000902

GO:0001666

GO:0001998

GO:0002363

GO:0002376

GO:0003013

GO:0003100

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005768

GO:0005789

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0006091

GO:0006357

GO:0006412

GO:0006464

GO:0006810

GO:0006950

GO:0007010

GO:0007015

GO:0007049

GO:0007155

GO:0007160

GO:0007165

GO:0007179

GO:0007186

GO:0007264

GO:0007266

GO:0007267

GO:0007519

GO:0008064

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008360

GO:0009058

GO:0009612

GO:0009749

GO:0010812

GO:0010975

GO:0010977

GO:0016020

GO:0016032

GO:0016192

GO:0016477

GO:0016579

GO:0016787

GO:0017022

GO:0019003

GO:0019899

GO:0019901

GO:0019904

GO:0021700

GO:0021762

GO:0021795

GO:0021861

GO:0022607

GO:0030027

GO:0030036

GO:0030054

GO:0030154

GO:0030307

GO:0030334

GO:0030335

GO:0030424

GO:0030425

GO:0030496

GO:0030521

GO:0030667

GO:0030838

GO:0030865

GO:0031098

GO:0031122

GO:0031234

GO:0031410

GO:0031532

GO:0031982

GO:0032154

GO:0032467

GO:0032587

GO:0032956

GO:0033144

GO:0033688

GO:0034329

GO:0034330

GO:0034446

GO:0034641

GO:0035385

GO:0036089

GO:0038027

GO:0040007

GO:0040011

GO:0042476

GO:0042493

GO:0042995

GO:0043123

GO:0043124

GO:0043149

GO:0043167

GO:0043197

GO:0043200

GO:0043226

GO:0043231

GO:0043280

GO:0043296

GO:0043297

GO:0043312

GO:0043366

GO:0043524

GO:0043525

GO:0043542

GO:0043931

GO:0044281

GO:0044319

GO:0044403

GO:0045198

GO:0045471

GO:0045665

GO:0045666

GO:0045727

GO:0045785

GO:0045792

GO:0045907

GO:0045987

GO:0046039

GO:0046638

GO:0048010

GO:0048013

GO:0048015

GO:0048646

GO:0048812

GO:0048856

GO:0048870

GO:0050771

GO:0050772

GO:0050773

GO:0050919

GO:0051022

GO:0051056

GO:0051301

GO:0051384

GO:0051496

GO:0051893

GO:0051924

GO:0060071

GO:0060193

GO:0060548

GO:0061024

GO:0061383

GO:0065003

GO:0070062

GO:0070507

GO:0071222

GO:0071345

GO:0071803

GO:0071902

GO:0071944

GO:0090051

GO:0090307

GO:0090324

GO:0097498

GO:0101003

GO:0140014

GO:1901224

GO:1902766

GO:1903427

GO:1903673

GO:1904695

GO:1904996

GO:1905244

GO:1990869

GO:2000145

GO:2000177

GO:2000406

Hs2.77273.2.S1_3p_s_at

ILMN_1781290

L25080_at

PH_hs_0004452

TC03001408.hg

Participant Of

hasMember

Ficolin-rich granule membrane proteins [ficolin-1-rich granule membrane]

Other forms of this molecule

RHOA [secretory granule membrane]

RHOA [endoplasmic reticulum membrane]

RHOA [cytosol]

RHOA [cell junction]

RHOA [plasma membrane]

Inferred To

RHO2 [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)

Rhoa [ficolin-1-rich granule membrane] (Mus musculus)

Rhoa [ficolin-1-rich granule membrane] (Rattus norvegicus)

rho1 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)

cRhoA [ficolin-1-rich granule membrane] (Gallus gallus)

rho4 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)

RHO3 [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)

RHO1 [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)

rho-1 [ficolin-1-rich granule membrane] (Caenorhabditis elegans)

RHOA [ficolin-1-rich granule membrane] (Bos taurus)

RHOA [ficolin-1-rich granule membrane] (Canis familiaris)

RHOA [ficolin-1-rich granule membrane] (Sus scrofa)

rho5 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)

RHO4 [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)

Homologues of RHOA [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)

Homologues of RHOA [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)

Rho1 [ficolin-1-rich granule membrane] (Drosophila melanogaster)

rho2 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)

rho3 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)

rhoa [ficolin-1-rich granule membrane] (Xenopus tropicalis)

rhoab [ficolin-1-rich granule membrane] (Danio rerio)

Cross References

RefSeq

NP_001300870.1, NP_001655.1

OpenTargets

ENSG00000067560

ZINC - Substances

RHOA_HUMAN

ZINC target

P61586

PRO

P61586

PDB

1X86, 3LW8, 4D0N, 5FR2, 3LXR, 5FR1, 1OW3, 5EZ6, 1XCG, 6BCB, 6BCA, 5JHH, 5C2K, 1S1C, 5HPY, 3MSX, 5C4M, 4XH9, 6R3V, 5JHG, 5BWM, 1CC0, 1A2B, 1TX4, 5A0F, 1FTN, 1LB1, 3LWN, 1CXZ, 3T06, 6BC0, 4XSH, 5IRC, 1DPF, 4XOI, 5JCP, 3KZ1, 5M6X, 2RGN, 5ZHX, 4XSG, 1KMQ, 5M70

Target Pathogen

5b354852be737e166372e841, 5b354852be737e166372e8a3

IntEnz

3.6.5.2

GeneCards

P61586

HPA

ENSG00000067560-RHOA

Ensembl

ENSG00000067560, ENSP00000400175, ENST00000418115

Orphanet

25605

ZINC - Predictions - Purchasable

RHOA_HUMAN

HMDB Protein

HMDBP01959

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BST9 RTKN	1	RTKN [cytosol] (R-HSA-5666184)	0.879	6
UniProt:O15085 ARHGEF11	1	ARHGEF11 [cytosol] (R-HSA-195102)	0.829	9
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.819	6
UniProt:Q8C6B2 Rtkn	2	Rtkn [cytosol] (R-MMU-5666184) Rtkn [cytosol] (R-MMU-5666187)	0.778	4
UniProt:Q9Y4D1 DAAM1	1	DAAM1 [cytosol] (R-HSA-351052)	0.729	5
UniProt:Q07960 ARHGAP1	1	ARHGAP1 [cytosol] (R-HSA-195193)	0.692	3
UniProt:Q6PDM6 Q6PDM6			0.667	3
UniProt:Q9Y4F9 RIPR2			0.666	4
UniProt:Q13464 ROCK1	6	ROCK1 [secretory granule lumen] (R-HSA-6804967) ROCK1 [extracellular region] (R-HSA-6806527) ROCK1(1114-1354) [cytosol] (R-HSA-212524) ROCK1(1-1113) [cytosol] (R-HSA-212523) ROCK1 [cytosol] (R-HSA-212509) Activated ROCK1 [cytosol] (R-HSA-4687777)	0.656	4
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.632	7
UniProt:Q9NZN5 ARHGEF12	1	ARHGEF12 [cytosol] (R-HSA-416560)	0.609	2
UniProt:O60610 DIAPH1	4	DIAPH1 [plasma membrane] (R-HSA-6801557) DIAPH1 [secretory granule membrane] (R-HSA-6801368) DIAPH1 [ficolin-1-rich granule membrane] (R-HSA-6801388) DIAPH1 [cytosol] (R-HSA-5665970)	0.602	3
UniProt:Q7Z6G8-3 ANKS1B			0.556	3
UniProt:Q9Y4F9-2 RIPOR2			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.556	3
UniProt:Q96MK2 RIPR3			0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9HCE7-2 SMURF1			0.544	2
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.544	3
UniProt:P0DTD1-PRO_0000449625 REP			0.527	2
UniProt:P08134 RHOC	2	RHOC [plasma membrane] (R-HSA-194870) RHOC [cytosol] (R-HSA-194853)	0.527	3
UniProt:P52306 GDS1			0.527	3
UniProt:Q9FD10 SSEJ			0.527	3
UniProt:Q15796 SMAD2	27	p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 Q429* [cytosol] (R-HSA-9668727) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) SMAD2 [nucleoplasm] (R-HSA-3006352) SMAD2 [cytosol] (R-HSA-3006353) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185)	0.524	2
UniProt:Q969H4 CNKSR1	1	CNKSR1 [cytosol] (R-HSA-5672629)	0.524	4
UniProt:O08808	4	Diaph1 [plasma membrane] (R-MMU-6801557) Diaph1 [secretory granule membrane] (R-MMU-6801368) Diaph1 [ficolin-1-rich granule membrane] (R-MMU-6801388) Diaph1 [cytosol] (R-MMU-5665970)	0.508	3
UniProt:Q9Z0S9 PRAF1			0.508	2
UniProt:Q6WCQ1 MPRIP	2	p-MPRIP-RAF1 fusion [cytosol] (R-HSA-6802540) MPRIP-RAF1 fusion [cytosol] (R-HSA-6802406)	0.499	3
UniProt:P19338 NCL	1	NCL [nucleoplasm] (R-HSA-6791213)	0.463	3

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