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RHOA [ficolin-1-rich granule membrane]
Stable Identifier
R-HSA-6804971
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ficolin-1-rich granule membrane
Synonyms
RhoA, Transforming protein RhoA, RHOA_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [ficolin-1-rich granule membrane] (Homo sapiens)
RHOA [ficolin-1-rich granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61586 RHOA
Gene Names
RHOA, ARH12, ARHA, RHO12
Chain
chain:1-190, propeptide:191-193
Reference Genes
BioGPS Gene:387 RHOA
COSMIC (genes):RHOA RHOA
CTD Gene:387 RHOA
dbSNP Gene:387 RHOA
ENSEMBL:ENSG00000067560 RHOA
HGNC:667 RHOA
KEGG Gene (Homo sapiens):387 RHOA
Monarch:387 RHOA
NCBI Gene:387 RHOA
OMIM:165390 RHOA
UCSC:P61586 RHOA
Reference Transcript
RefSeq:NM_001313941.1 RHOA
RefSeq:NM_001664.3 RHOA
Other Identifiers
0005220088
11743726_s_at
11753410_a_at
11754043_a_at
11757012_x_at
1394_at
1555814_a_at
16954055
18670076
18670077
18670078
18670080
18670081
200059_PM_s_at
200059_s_at
2674238
2674239
2674240
2674241
2674243
2674244
2674245
2674246
2674247
2674248
2674249
2674252
2674253
2674255
2674258
2674265
2674266
2965039
37309_at
387
4000064
7892846
7893424
7893647
7893815
7894083
7895551
7895657
7896138
7896438
8087409
A_23_P69491
A_23_P69493
A_24_P174550
GE79565
GO:0000166
GO:0000278
GO:0000902
GO:0001666
GO:0001998
GO:0002363
GO:0002376
GO:0003013
GO:0003100
GO:0003674
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005768
GO:0005789
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0005938
GO:0006091
GO:0006357
GO:0006412
GO:0006464
GO:0006810
GO:0006950
GO:0007010
GO:0007015
GO:0007049
GO:0007155
GO:0007160
GO:0007165
GO:0007179
GO:0007186
GO:0007264
GO:0007266
GO:0007267
GO:0007519
GO:0008064
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008360
GO:0009058
GO:0009612
GO:0009749
GO:0010812
GO:0010975
GO:0010977
GO:0016020
GO:0016032
GO:0016192
GO:0016477
GO:0016579
GO:0016787
GO:0017022
GO:0019003
GO:0019899
GO:0019901
GO:0019904
GO:0021700
GO:0021762
GO:0021795
GO:0021861
GO:0022607
GO:0030027
GO:0030036
GO:0030054
GO:0030154
GO:0030307
GO:0030334
GO:0030335
GO:0030424
GO:0030425
GO:0030496
GO:0030521
GO:0030667
GO:0030838
GO:0030865
GO:0031098
GO:0031122
GO:0031234
GO:0031410
GO:0031532
GO:0031982
GO:0032154
GO:0032467
GO:0032587
GO:0032956
GO:0033144
GO:0033688
GO:0034329
GO:0034330
GO:0034446
GO:0034641
GO:0035385
GO:0036089
GO:0038027
GO:0040007
GO:0040011
GO:0042476
GO:0042493
GO:0042995
GO:0043123
GO:0043124
GO:0043149
GO:0043167
GO:0043197
GO:0043200
GO:0043226
GO:0043231
GO:0043280
GO:0043296
GO:0043297
GO:0043312
GO:0043366
GO:0043524
GO:0043525
GO:0043542
GO:0043931
GO:0044281
GO:0044319
GO:0044403
GO:0045198
GO:0045471
GO:0045665
GO:0045666
GO:0045727
GO:0045785
GO:0045792
GO:0045907
GO:0045987
GO:0046039
GO:0046638
GO:0048010
GO:0048013
GO:0048015
GO:0048646
GO:0048812
GO:0048856
GO:0048870
GO:0050771
GO:0050772
GO:0050773
GO:0050919
GO:0051022
GO:0051056
GO:0051301
GO:0051384
GO:0051496
GO:0051893
GO:0051924
GO:0060071
GO:0060193
GO:0060548
GO:0061024
GO:0061383
GO:0065003
GO:0070062
GO:0070507
GO:0071222
GO:0071345
GO:0071803
GO:0071902
GO:0071944
GO:0090051
GO:0090307
GO:0090324
GO:0097498
GO:0101003
GO:0140014
GO:1901224
GO:1902766
GO:1903427
GO:1903673
GO:1904695
GO:1904996
GO:1905244
GO:1990869
GO:2000145
GO:2000177
GO:2000406
Hs2.77273.2.S1_3p_s_at
ILMN_1781290
L25080_at
PH_hs_0004452
TC03001408.hg
Participant Of
hasMember
Ficolin-rich granule membrane proteins [ficolin-1-rich granule membrane]
Other forms of this molecule
RHOA [secretory granule membrane]
RHOA [endoplasmic reticulum membrane]
RHOA [cytosol]
RHOA [cell junction]
RHOA [plasma membrane]
Inferred To
RHO2 [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)
Rhoa [ficolin-1-rich granule membrane] (Mus musculus)
Rhoa [ficolin-1-rich granule membrane] (Rattus norvegicus)
rho1 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)
cRhoA [ficolin-1-rich granule membrane] (Gallus gallus)
rho4 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)
RHO3 [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)
RHO1 [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)
rho-1 [ficolin-1-rich granule membrane] (Caenorhabditis elegans)
RHOA [ficolin-1-rich granule membrane] (Bos taurus)
RHOA [ficolin-1-rich granule membrane] (Canis familiaris)
RHOA [ficolin-1-rich granule membrane] (Sus scrofa)
rho5 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)
RHO4 [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)
Homologues of RHOA [ficolin-1-rich granule membrane] (Saccharomyces cerevisiae)
Homologues of RHOA [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)
Rho1 [ficolin-1-rich granule membrane] (Drosophila melanogaster)
rho2 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)
rho3 [ficolin-1-rich granule membrane] (Schizosaccharomyces pombe)
rhoa [ficolin-1-rich granule membrane] (Xenopus tropicalis)
rhoab [ficolin-1-rich granule membrane] (Danio rerio)
Cross References
RefSeq
NP_001300870.1
,
NP_001655.1
OpenTargets
ENSG00000067560
ZINC - Substances
RHOA_HUMAN
ZINC target
P61586
PRO
P61586
PDB
1X86
,
3LW8
,
4D0N
,
5FR2
,
3LXR
,
5FR1
,
1OW3
,
5EZ6
,
1XCG
,
6BCB
,
6BCA
,
5JHH
,
5C2K
,
1S1C
,
5HPY
,
3MSX
,
5C4M
,
4XH9
,
6R3V
,
5JHG
,
5BWM
,
1CC0
,
1A2B
,
1TX4
,
5A0F
,
1FTN
,
1LB1
,
3LWN
,
1CXZ
,
3T06
,
6BC0
,
4XSH
,
5IRC
,
1DPF
,
4XOI
,
5JCP
,
3KZ1
,
5M6X
,
2RGN
,
5ZHX
,
4XSG
,
1KMQ
,
5M70
Target Pathogen
5b354852be737e166372e841
,
5b354852be737e166372e8a3
IntEnz
3.6.5.2
GeneCards
P61586
HPA
ENSG00000067560-RHOA
Ensembl
ENSG00000067560
,
ENSP00000400175
,
ENST00000418115
Orphanet
25605
ZINC - Predictions - Purchasable
RHOA_HUMAN
HMDB Protein
HMDBP01959
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BST9 RTKN
1
RTKN [cytosol]
(R-HSA-5666184)
0.879
6
UniProt:O15085 ARHGEF11
1
ARHGEF11 [cytosol]
(R-HSA-195102)
0.829
9
UniProt:P52565 ARHGDIA
1
ARHGDIA [cytosol]
(R-HSA-194478)
0.819
6
UniProt:Q8C6B2 Rtkn
2
Rtkn [cytosol]
(R-MMU-5666184)
Rtkn [cytosol]
(R-MMU-5666187)
0.778
4
UniProt:Q9Y4D1 DAAM1
1
DAAM1 [cytosol]
(R-HSA-351052)
0.729
5
UniProt:Q07960 ARHGAP1
1
ARHGAP1 [cytosol]
(R-HSA-195193)
0.692
3
UniProt:Q6PDM6 Q6PDM6
0.667
3
UniProt:Q9Y4F9 RIPR2
0.666
4
UniProt:Q13464 ROCK1
6
ROCK1 [secretory granule lumen]
(R-HSA-6804967)
ROCK1 [extracellular region]
(R-HSA-6806527)
ROCK1(1114-1354) [cytosol]
(R-HSA-212524)
ROCK1(1-1113) [cytosol]
(R-HSA-212523)
ROCK1 [cytosol]
(R-HSA-212509)
Activated ROCK1 [cytosol]
(R-HSA-4687777)
0.656
4
UniProt:A0A0F6B1Q8 A0A0F6B1Q8
0.632
7
UniProt:Q9NZN5 ARHGEF12
1
ARHGEF12 [cytosol]
(R-HSA-416560)
0.609
2
UniProt:O60610 DIAPH1
4
DIAPH1 [plasma membrane]
(R-HSA-6801557)
DIAPH1 [secretory granule membrane]
(R-HSA-6801368)
DIAPH1 [ficolin-1-rich granule membrane]
(R-HSA-6801388)
DIAPH1 [cytosol]
(R-HSA-5665970)
0.602
3
UniProt:Q7Z6G8-3 ANKS1B
0.556
3
UniProt:Q9Y4F9-2 RIPOR2
0.556
3
UniProt:Q15654 TRIP6
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q92974 ARHGEF2
1
ARHGEF2 [cytosol]
(R-HSA-195101)
0.556
3
UniProt:Q96MK2 RIPR3
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9HCE7-2 SMURF1
0.544
2
UniProt:P46527 CDKN1B
8
CDKN1B [nucleoplasm]
(R-HSA-182563)
CDKN1B [cytosol]
(R-HSA-198622)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.544
3
UniProt:P0DTD1-PRO_0000449625 REP
0.527
2
UniProt:P08134 RHOC
2
RHOC [plasma membrane]
(R-HSA-194870)
RHOC [cytosol]
(R-HSA-194853)
0.527
3
UniProt:P52306 GDS1
0.527
3
UniProt:Q9FD10 SSEJ
0.527
3
UniProt:Q15796 SMAD2
27
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
SMAD2 S467P [cytosol]
(R-HSA-3304375)
SMAD2 Q429* [cytosol]
(R-HSA-9668727)
p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009189)
SMAD2 [nucleoplasm]
(R-HSA-3006352)
SMAD2 [cytosol]
(R-HSA-3006353)
p-S465,S467-SMAD2 [cytosol]
(R-HSA-3009186)
p-S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009185)
0.524
2
UniProt:Q969H4 CNKSR1
1
CNKSR1 [cytosol]
(R-HSA-5672629)
0.524
4
UniProt:O08808
4
Diaph1 [plasma membrane]
(R-MMU-6801557)
Diaph1 [secretory granule membrane]
(R-MMU-6801368)
Diaph1 [ficolin-1-rich granule membrane]
(R-MMU-6801388)
Diaph1 [cytosol]
(R-MMU-5665970)
0.508
3
UniProt:Q9Z0S9 PRAF1
0.508
2
UniProt:Q6WCQ1 MPRIP
2
p-MPRIP-RAF1 fusion [cytosol]
(R-HSA-6802540)
MPRIP-RAF1 fusion [cytosol]
(R-HSA-6802406)
0.499
3
UniProt:P19338 NCL
1
NCL [nucleoplasm]
(R-HSA-6791213)
0.463
3
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