Reactome | p14ARF sequesters MDM2

p14ARF sequesters MDM2

Stable Identifier

R-HSA-6804996

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - Oncogene Induced Senescence (Homo sapiens)
      - p14ARF sequesters MDM2 (Homo sapiens)
    - Oxidative Stress Induced Senescence (Homo sapiens)
      - p14ARF sequesters MDM2 (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        p14ARF sequesters MDM2 (Homo sapiens)

General

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Binding of p14ARF to MDM2 decreases the half-life of MDM2, likely through promoting MDM2 degradation. Thus, p14ARF inhibits MDM2-mediated ubiquitination and degradation of TP53 (Zhang et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9529249	ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways Zhang, Y, Xiong, Y, Yarbrough, WG	Cell	1998

Participants

Input

p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)

Output

Participates

as an event of

Authored

Orlic-Milacic, M (2013-07-15)

Reviewed

Zaccara, S (2016-02-04)

Samarajiwa, S (2013-09-03)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-16)

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