p14-ARF forms a ternary complex with MDM2 and TP53

Stable Identifier
R-HSA-6804998
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

p14-ARF forms a complex with TP53-bound MDM2 by interacting with the C-terminus of MDM2, while the N-terminus of MDM2 is involved in TP53 (p53) binding. p14-ARF cannot associate with TP53 in the absence of MDM2 (Zhang et al. 1998).

Participants
Participant Of
Orthologous Events