Reactome | p14ARF forms a ternary complex with MDM2 and TP53

p14ARF forms a ternary complex with MDM2 and TP53

Stable Identifier

R-HSA-6804998

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)

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p14ARF forms a ternary complex with MDM2 and TP53

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p14ARF forms a complex with TP53-bound MDM2 by interacting with the C-terminus of MDM2, while the N-terminus of MDM2 is involved in TP53 (p53) binding. p14ARF cannot associate with TP53 in the absence of MDM2 (Zhang et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9529249	ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways Zhang, Y, Xiong, Y, Yarbrough, WG	Cell	1998

Participants

Input

Output

p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)

Participates

as an event of

Authored

Orlic-Milacic, M (2013-07-15)

Reviewed

Zaccara, S (2016-02-04)

Samarajiwa, S (2013-09-03)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-16)

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