USP2 binds the heterodimer of MDM2 and MDM4

Stable Identifier
R-HSA-6805022
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The ubiquitin protease USP2 forms a tripartite complex with MDM2 and MDM4 (MDMX) by binding to the ubiquitinated heterodimer of MDM2 and MDM4 (Allende-Vega et al. 2010).

Literature References
PubMed ID Title Journal Year
19838211 MdmX is a substrate for the deubiquitinating enzyme USP2a

Allende-Vega, N, Sparks, A, Lane, DP, Saville, MK

Oncogene 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed