Reactome | CSNK2B [nucleoplasm]

CSNK2B [nucleoplasm]

Stable Identifier

R-HSA-6805067

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Casein kinase II beta subunit

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
        
        Maturation of hRSV A proteins (Homo sapiens)
        
        M dimer is phosphorylated (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CK2 binds FACT (Homo sapiens)
        
        CK2:FACT [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
        
        CK2:FACT phosphorylates TP53 (Homo sapiens)
        
        CK2:FACT [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P67870 CSNK2B

Gene Names

CSNK2B, CK2N, G5A

Chain

initiator methionine:, chain:2-215

Reference Genes

BioGPS Gene:1460 CSNK2B

COSMIC (genes):CSNK2B CSNK2B

CTD Gene:1460 CSNK2B

dbSNP Gene:1460 CSNK2B

ENSEMBL:ENSG00000204435 CSNK2B

ENSEMBL_homo_sapiens_GENE:ENSG00000204435.15 CSNK2B

ENSEMBL_homo_sapiens_GENE:ENSG00000206406.9 CSNK2B

ENSEMBL_homo_sapiens_GENE:ENSG00000224398.7 CSNK2B

ENSEMBL_homo_sapiens_GENE:ENSG00000224774.7 CSNK2B

ENSEMBL_homo_sapiens_GENE:ENSG00000228875.8 CSNK2B

ENSEMBL_homo_sapiens_GENE:ENSG00000230700.11 CSNK2B

ENSEMBL_homo_sapiens_GENE:ENSG00000232960.12 CSNK2B

HGNC:2460 CSNK2B

KEGG Gene (Homo sapiens):1460 CSNK2B

Monarch:1460 CSNK2B

NCBI Gene:1460 CSNK2B

OMIM:115441 CSNK2B

UCSC:P67870 CSNK2B

Reference Transcript

Other Identifiers

11723718_a_at

11745786_a_at

11747530_a_at

11757576_x_at

1460

201390_PM_s_at

201390_s_at

2902561

2902562

2902563

2902564

2902565

2902566

2902568

2902570

2902571

2902572

410_s_at

8118218

8178050

8179298

A_33_P3318027

GO:0000785

GO:0003682

GO:0003824

GO:0004674

GO:0005102

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0005956

GO:0007165

GO:0008285

GO:0016055

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0018107

GO:0019887

GO:0019904

GO:0023052

GO:0030674

GO:0031410

GO:0031519

GO:0032927

GO:0033211

GO:0034774

GO:0036211

GO:0042802

GO:0043226

GO:0043537

GO:0046872

GO:0048856

GO:0048870

GO:0051101

GO:0060090

GO:0060391

GO:0061154

GO:0061629

GO:0065003

GO:0070062

GO:0075342

GO:0098772

GO:0140096

GO:1903901

GO:1904813

HMNXSV003021467

PH_hs_0022181

X57152_rna1_s_at

g10334850_3p_s_at

Participates

as a component of

Casein kinase II [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CSNK2B [secretory granule lumen]

CSNK2B [extracellular region]

CSNK2B [ficolin-1-rich granule lumen]

CSNK2B [cytosol]

Inferred To

csnk2b [nucleoplasm] (Dictyostelium discoideum)

csnk2b [nucleoplasm] (Xenopus tropicalis)

CkIIbeta [nucleoplasm] (Drosophila melanogaster)

CSNK2B [nucleoplasm] (Bos taurus)

CSNK2B [nucleoplasm] (Canis familiaris)

CSNK2B [nucleoplasm] (Mus musculus)

CSNK2B [nucleoplasm] (Plasmodium falciparum)

CSNK2B [nucleoplasm] (Rattus norvegicus)

CSNK2B [nucleoplasm] (Sus scrofa)

CKB2 [nucleoplasm] (Saccharomyces cerevisiae)

kin-10 [nucleoplasm] (Caenorhabditis elegans)

ckb1 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of CSNK2B [nucleoplasm] (Gallus gallus)

Cross References

RefSeq

NP_001311.3, NP_001269314.1

Guide to Pharmacology - Targets

1551

OpenTargets

ENSG00000204435

HPA

ENSG00000204435-CSNK2B

GeneCards

P67870

Ensembl

ENST00000452985, ENST00000443673, ENST00000436169, ENST00000454511, ENSP00000411322, ENSP00000390900, ENST00000418230, ENSP00000382980, ENSP00000415237, ENST00000400110, ENSP00000400188, ENST00000451917, ENST00000375866, ENSP00000372919, ENSP00000391038, ENSP00000365026, ENSP00000407379, ENSP00000409510, ENST00000422567, ENSP00000415303, ENSP00000393756, ENSG00000224774, ENST00000412802, ENSG00000232960, ENST00000453234, ENSG00000204435, ENSP00000410802, ENSG00000224398, ENSG00000228875, ENST00000454382, ENST00000458330, ENSP00000372925, ENSP00000395275, ENSP00000413469, ENST00000431476, ENSP00000394855, ENSP00000412520, ENST00000383427, ENSP00000365042, ENSP00000365025, ENSP00000407018, ENST00000429633, ENST00000383433, ENST00000455161, ENST00000375865, ENSG00000230700, ENST00000448596, ENSG00000206406, ENST00000375882

PRO

P67870

Pharos - Targets

P67870

Orphanet

25556

HMDB Protein

HMDBP10475

PDB

4MD7, 1JWH, 6Q38, 4DGL, 4NH1, 4MD8, 1QF8, 1DS5, 4MD9, 3EED

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.725	5
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.666	4
UniProt:O75582 RPS6KA5	3	RPS6KA5 [cytosol] (R-HSA-772525) RPS6KA5 [nucleoplasm] (R-HSA-198657) p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (R-HSA-198683)	0.659	3
UniProt:Q9WTL8 Arntl	4	p-S-Arntl [nucleoplasm] (R-MMU-508690) Arntl [cytosol] (R-MMU-508660) Bmal1 [nucleoplasm] (R-MMU-9634872) Arntl [nucleoplasm] (R-MMU-9769624)	0.646	4
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.643	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.643	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.626	5
UniProt:Q6VY07 PACS1	1	PACS1 [cytosol] (R-HSA-167634)	0.593	3
UniProt:P97784 Cry1	4	Cry1 [cytosol] (R-MMU-508637) p-Cry1 [cytosol] (R-MMU-508644) p-Cry1 [nucleoplasm] (R-MMU-508662) ub-p-Cry1 [nucleoplasm] (R-MMU-517961)	0.592	2
UniProt:Q9UBS0 RPS6KB2	2	p-S15,S356-RPS6KB2 [nucleoplasm] (R-HSA-199844) RPS6KB2 [nucleoplasm] (R-HSA-199877)	0.589	3
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.547	2
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.527	3
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372)	0.527	2
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.527	2
UniProt:Q92794 KAT6A	3	KAT6A (1-1118) [nucleoplasm] (R-HSA-5603260) p-T369-KAT6A [nucleoplasm] (R-HSA-6805633) KAT6A [nucleoplasm] (R-HSA-480310)	0.527	2
UniProt:Q8WUQ7 CACTIN	1	CACTIN [nucleoplasm] (R-HSA-9769591)	0.527	3
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.527	2
UniProt:Q86US8 SMG6	1	SMG6 [cytosol] (R-HSA-927851)	0.527	2
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.527	2
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.527	2
UniProt:O08785 Clock	2	p-S-Clock [nucleoplasm] (R-MMU-508670) Clock [cytosol] (R-MMU-508720)	0.508	2

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