Reactome | ANAPC16 [nucleoplasm]

ANAPC16 [nucleoplasm]

Stable Identifier

R-HSA-6805137

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Anaphase-promoting complex subunit 16, APC16_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC16 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC16 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96DE5 ANAPC16

Gene Names

ANAPC16, C10orf104, CENP-27

Chain

initiator methionine:, chain:2-110

Reference Genes

BioGPS Gene:119504 ANAPC16

COSMIC (genes):ANAPC16 ANAPC16

CTD Gene:119504 ANAPC16

dbSNP Gene:119504 ANAPC16

ENSEMBL:ENSG00000166295 ANAPC16

HGNC:26976 ANAPC16

KEGG:hsa:119504 ANAPC16

Monarch:119504 ANAPC16

NCBI Gene:119504 ANAPC16

OMIM:613427 ANAPC16

UCSC:Q96DE5 ANAPC16

Reference Transcript

Other Identifiers

11729130_at

11756599_a_at

119504

16705942

224664_PM_at

224664_at

224665_PM_at

224665_at

224667_3p_x_at

224667_PM_x_at

224667_x_at

229145_PM_at

229145_at

2679190

3251354

3251355

3251356

3251363

3251368

3251369

3251370

3251377

3251379

3251380

3251381

3251382

3251383

3251385

45238_at

48988_at

50851_at

59706_s_at

64149_at

7928300

A_14_P104833

A_14_P129608

A_32_P32207

A_33_P3216955

GE473513

GE88496

GO:0000775

GO:0000776

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005694

GO:0005737

GO:0005829

GO:0007346

GO:0016567

GO:0030163

GO:0031145

GO:0043226

GO:0051301

GO:0051445

GO:0070936

GO:0070979

GO:0141198

HMNXSV003046839

Hs.122586.0.A1_3p_at

Hs.178485.0.S1_3p_at

Hs.178485.0.S2_3p_at

ILMN_1738955

PH_hs_0019840

PH_hs_0033290

TC10000443.hg

TC10002123.hg

Participates

as a component of

Other forms of this molecule

ANAPC16 [cytosol]

Inferred To

ANAPC16 [nucleoplasm] (Bos taurus)

ANAPC16 [nucleoplasm] (Canis familiaris)

ANAPC16 [nucleoplasm] (Gallus gallus)

ANAPC16 [nucleoplasm] (Sus scrofa)

Anapc16 [nucleoplasm] (Mus musculus)

Anapc16 [nucleoplasm] (Rattus norvegicus)

anapc16 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of ANAPC16 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of ANAPC16 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001229475.1, NP_001229476.1, NP_775744.1

OpenTargets

ENSG00000166295

ENSEMBL

ENSP00000299381, ENSP00000477760, ENST00000621663, ENST00000299381

HPA

ENSG00000166295-ANAPC16

PRO

Q96DE5

Pharos - Targets

Q96DE5

PDB

6TNT, 5L9U, 4UI9, 5A31, 8S4G, 5KHU, 5LCW, 7QE7, 4RG6, 8TAU, 6Q6G, 6TM5, 5L9T, 6Q6H, 4RG9, 5KHR, 5G05, 5G04, 6TLJ, 8TAR, 8PKP

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.725	5
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.643	3
UniProt:Q9Z1S0	1	BUB1B [cytosol] (R-MMU-141436)	0.564	2
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.527	2
UniProt:Q9UM11 FZR1	4	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193)	0.527	3
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [cytosol] (R-HSA-177324) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) FBXO5 [nucleoplasm] (R-HSA-174060) p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-FBXO5 [nucleoplasm] (R-HSA-163049)	0.527	3

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