Reactome | GPR32 [plasma membrane]

GPR32 [plasma membrane]

Stable Identifier

R-HSA-6805228

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Probable G-protein coupled receptor 32, GPR32_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR32 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR32 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR32 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR32 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR32 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR32 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75388 GPR32

Gene Names

GPR32

Chain

chain:1-356

Reference Genes

BioGPS Gene:2854 GPR32

COSMIC (genes):GPR32 GPR32

CTD Gene:2854 GPR32

dbSNP Gene:2854 GPR32

ENSEMBL:ENSG00000142511 GPR32

ENSEMBL_homo_sapiens_GENE:ENSG00000142511.4 GPR32

HGNC:4487 GPR32

KEGG Gene (Homo sapiens):2854 GPR32

Monarch:2854 GPR32

NCBI Gene:2854 GPR32

OMIM:603195 GPR32

UCSC:O75388 GPR32

Reference Transcript

RefSeq:NM_001506.2 GPR32

Other Identifiers

11715127_s_at

11759354_s_at

11759355_x_at

16864584

221469_PM_at

221469_at

2854

3839491

3839492

3839493

3839494

8030731

8030733

ADDON002793.hg

A_14_P124261

A_23_P142096

GE80664

GO:0002376

GO:0002430

GO:0004875

GO:0004930

GO:0004982

GO:0005886

GO:0006954

GO:0007165

GO:0007186

GO:0007200

GO:0007204

GO:0016020

GO:0023052

GO:0060089

HMNXSV003049248

ILMN_1651457

PH_hs_0029504

TC19000766.hg

g4504092_3p_at

Participates

as a member of

Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)

Inferred To

GPR32 [plasma membrane] (Sus scrofa)

LOC100491504 [plasma membrane] (Xenopus tropicalis)

Homologues of GPR32 [plasma membrane] (Xenopus tropicalis)

LOC108648060 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001497.1

Guide to Pharmacology - Targets

OpenTargets

ENSG00000142511

GeneCards

O75388

HPA

ENSG00000142511-GPR32

Ensembl

ENSG00000142511, ENST00000270590, ENSP00000270590

PRO

O75388

Pharos - Targets

O75388