CDK5 phosphorylates TP53

Stable Identifier
R-HSA-6805276
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CDK5, in complex with cleaved CDK5R1 (p25), which ensures nuclear localization (Patrick et al. 1999, Lee et al. 2008), phosphorylates TP53 (p53) on serine residues S15, S33 and S46. CDK5-mediated phosphorylation of TP53 promotes transcription of pro-apoptotic genes and neuronal cell death (Zhang et al. 2002, Lee et al. 2007, Lee et al. 2008).

Literature References
PubMed ID Title Journal Year
17591690 Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

Lee, JH, Kim, HS, Lee, SJ, Kim, KT

J. Cell. Sci. 2007
10604467 Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Patrick, GN, Zukerberg, L, Nikolic, M, de la Monte, S, Dikkes, P, Tsai, LH

Nature 1999
12064478 Cdk5 phosphorylates p53 and regulates its activity

Zhang, J, Krishnamurthy, PK, Johnson, GV

J. Neurochem. 2002
10500146 Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation

Sharma, P, Sharma, M, Amin, ND, Albers, RW, Pant, HC

Proc. Natl. Acad. Sci. U.S.A. 1999
18490454 Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress

Lee, JH, Jeong, MW, Kim, W, Choi, YH, Kim, KT

J. Biol. Chem. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-Y15,S159-CDK5:CDK5R1 (99-307) [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created