PLK3 phosphorylates TP53

Stable Identifier
R-HSA-6805285
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PLK3 contributes to stabilizing phosphorylation of TP53 on serine residue S20 (Xie, Wang et al. 2001, Xie, Wu et al. 2001).

Literature References
PubMed ID Title Journal Year
11447225 Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3

Xie, S, Wang, Q, Wu, H, Cogswell, J, Lu, L, Jhanwar-Uniyal, M, Dai, W

J. Biol. Chem. 2001
11551930 Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

Xie, S, Wu, H, Wang, Q, Cogswell, JP, Husain, I, Conn, C, Stambrook, P, Jhanwar-Uniyal, M, Dai, W

J. Biol. Chem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PLK3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created