CARD8 binds CASP9(1-416)

Stable Identifier
R-HSA-6805426
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
TUCAN binds pro-caspase-9
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Caspase activating and recruitment domain 8 protein (CARD8, also known as TUCAN, CARDINAL) has been implicated as a regulator of several pro-inflammatory and apoptotic signaling pathways. The C-terminal CARD domain of CARD8 (TUCAN) binds procaspase-9 (CASP9(1-416)) and interferes with binding of APAF1 to procaspase-9 thus suppressing caspase activation induced by the APAF1:cytochrome c (CYCS) axis (Pathan N et al. 2001). The structural studies of CARD8 suggest that in addition to intermolecular CARD-CARD interactions, CARD domain may intramolecularly associate with the N-terminal function to find domain (FIIND) to regulate apoptotic and inflammatory signaling pathways (Jin T et al. 2013).

Several binding partners of CARD8 have been reported. CARD8 can interact physically via CARD domain with caspase-1 and negatively regulates caspase-1-dependent IL-1beta generation in the THP-1 monocytic cell line (Razmara M et al. 2002). The FIIND domain of CARD8 may inhibit NFkappaB activation, possibly through interaction with IKKgamma (Bouchier-Hayes L et al. 2001). FIIND may also bind the nucleotide-binding domain (NBD) domain of NOD2 and NLRP3 to regulate the immune response to bacterial infections (Kampen O et al. 2010).

High levels of CARD8 expression have been observed in several tumor cell lines and malignant specimens from human patients underlying its importance in regulating inflammatory and apoptotic pathways (Bouchier-Hayes L et al. 2001; Pathan N et al. 2001; Razmara M et al. 2002; Zhang H & Fu W 2002; Yamamoto M et al. 2005).

Literature References
PubMed ID Title Journal Year
11408476 TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer

Pathan, N, Marusawa, H, Krajewska, M, Matsuzawa, S, Kim, H, Okada, K, Torii, S, Kitada, S, Krajewski, S, Welsh, K, Pio, F, Godzik, A, Reed, JC

J. Biol. Chem. 2001
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