AMPK phosphorylates TP53

Stable Identifier
R-HSA-6805470
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AMPK, activated in response to glucose deprivation, phosphorylates TP53 (p53) on serine residue S15, initiating AMPK-dependent cell cycle arrest (Jones et al. 2005). AMPK-dependent phosphorylation of TP73 (p73) appears to be involved in TP53 stabilization upon AMPK activation (Adamovich et al. 2014).

Literature References
PubMed ID Title Journal Year
15866171 AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

Jones, RG, Plas, DR, Kubek, S, Buzzai, M, Mu, J, Xu, Y, Birnbaum, MJ, Thompson, CB

Mol. Cell 2005
24874608 AMPK couples p73 with p53 in cell fate decision

Adamovich, Y, Adler, J, Meltser, V, Reuven, N, Shaul, Y

Cell Death Differ. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
AMP-activated protein kinase activity of Activated AMPK heterotrimer [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created