TP53RK phosphorylates TP53

Stable Identifier
R-HSA-6805479
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The atypical protein serine/threonine kinase TP53RK (TP53-regulating kinase), also known as PRPK (p53-related protein kinase), phosphorylates TP53 (p53) on serine residue S15 (Abe et al. 2001, Facchin et al. 2003).

Literature References
PubMed ID Title Journal Year
12914926 Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency

Facchin, S, Lopreiato, R, Ruzzene, M, Marin, O, Sartori, G, Götz, C, Montenarh, M, Carignani, G, Pinna, LA

FEBS Lett. 2003
11546806 Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes

Abe, Y, Matsumoto, S, Wei, S, Nezu, K, Miyoshi, A, Kito, K, Ueda, N, Shigemoto, K, Hitsumoto, Y, Nikawa, J, Enomoto, Y

J. Biol. Chem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of TP53RK [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed