APAF1 binds AVEN

Stable Identifier
R-HSA-6805507
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The binding of AVEN to apoptotic protease activating factor 1 (APAF1) is thought to interfere with the ability of APAF1 to self-associate during apoptosome assembly (Chau BN et al. 2000). The anti-apoptotic function of AVEN may require the proteolytic removal of the inhibitory N-terminus of AVEN (Melzer IM et al. 2012).

Literature References
PubMed ID Title Journal Year
10949025 Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1

Chau, BN, Cheng, EH, Kerr, DA, Hardwick, JM

Mol. Cell 2000
Participants
Participant Of
Orthologous Events
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Created