KAT6A acetylates TP53

Stable Identifier
R-HSA-6805638
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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KAT6A histone acetyltransferase, part of the MOZ/MORF complex, acetylates TP53 (p53) on lysine residues K120 and K382. The acetylation of TP53 by KAT6A is enhanced in the presence of PML and results in increased transcriptional activation of the CDKN1A (p21) gene by TP53 (Rokudai et al. 2013).

Literature References
PubMed ID Title Journal Year
23431171 MOZ increases p53 acetylation and premature senescence through its complex formation with PML

Rokudai, S, Laptenko, O, Arnal, SM, Taya, Y, Kitabayashi, I, Prives, C

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acetyltransferase activity of KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created