AKT phosphorylates KAT6A

Stable Identifier
R-HSA-6805640
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated AKT phosphorylates the histone acetyltransferase KAT6A on threonine residue T369, preventing association of PML with the KAT6A complex and repressing KAT6A-mediated acetylation of TP53 (p53) (Rokudai et al. 2013).

Literature References
PubMed ID Title Journal Year
23431171 MOZ increases p53 acetylation and premature senescence through its complex formation with PML

Rokudai, S, Laptenko, O, Arnal, SM, Taya, Y, Kitabayashi, I, Prives, C

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created