There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

SETD9 methylates TP53

Stable Identifier
R-HSA-6805730
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The lysine methyltransferase SETD9 methylates TP53 (p53) on lysine residue K372. Methylation at K372 increases stability of TP53 and promotes transcription of TP53 target genes CDKN1A (p21), BAX and MDM2 (Chuikov et al. 2004, Couture et al. 2006). SETD9 may both mono- and dimethylate TP53 (Bai et al. 2011).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lysine N-methyltransferase activity of SETD9 [nucleoplasm]
Physical Entity
Activity
Orthologous Events