Reactome: A Curated Pathway Database

SETD9 methylates TP53

Stable Identifier
R-HSA-6805730
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The lysine methyltransferase SETD9 methylates TP53 (p53) on lysine residue K372. Methylation at K372 increases stability of TP53 and promotes transcription of TP53 target genes CDKN1A (p21), BAX and MDM2 (Chuikov et al. 2004, Couture et al. 2006). SETD9 may both mono- and dimethylate TP53 (Bai et al. 2011).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
lysine N-methyltransferase activity of SETD9 [nucleoplasm] SETD9 [nucleoplasm] lysine N-methyltransferase activity (0016278)
Orthologous Events