SETD9 methylates TP53

Stable Identifier
R-HSA-6805730
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The lysine methyltransferase SETD9 methylates TP53 (p53) on lysine residue K372. Methylation at K372 increases stability of TP53 and promotes transcription of TP53 target genes CDKN1A (p21), BAX and MDM2 (Chuikov et al. 2004, Couture et al. 2006). SETD9 may both mono- and dimethylate TP53 (Bai et al. 2011).

Literature References
PubMed ID Title Journal Year
15525938 Regulation of p53 activity through lysine methylation

Chuikov, S, Kurash, JK, Wilson, JR, Xiao, B, Justin, N, Ivanov, GS, McKinney, K, Tempst, P, Prives, C, Gamblin, SJ, Barlev, NA, Reinberg, D

Nature 2004
16415881 Structural basis for the methylation site specificity of SET7/9

Couture, JF, Collazo, E, Hauk, G, Trievel, RC

Nat. Struct. Mol. Biol. 2006
21625555 Modeling a new water channel that allows SET9 to dimethylate p53

Bai, Q, Shen, Y, Yao, X, Wang, F, Du, Y, Wang, Q, Jin, N, Hai, J, Hu, T, Yang, J

PLoS ONE 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lysine N-methyltransferase activity of SETD9 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created