Reactome: A Curated Pathway Database

SETD8 methylates TP53

Stable Identifier
R-HSA-6805740
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The protein lysine methyltransferase SETD8 (SET8) monomethylates TP53 (p53) on lysine residue K382, resulting in repression of TP53 transcriptional activity (Shi et al. 2007).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
lysine N-methyltransferase activity of SETD8 [nucleoplasm] SETD8 [nucleoplasm] lysine N-methyltransferase activity (0016278)
Orthologous Events