Reactome: A Curated Pathway Database

EHMT1:EHMT2 dimethylates TP53

Stable Identifier
R-HSA-6805755
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The complex of lysine methyltransferases EHMT1 and EHMT2 dimethylates inactive TP53 at lysine residue K373, resulting in additional inhibition of TP53 activity (Huang et al. 2010).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
lysine N-methyltransferase activity of EHMT1:EHMT2 [nucleoplasm] EHMT1:EHMT2 [nucleoplasm] lysine N-methyltransferase activity (0016278)
Orthologous Events