p-S291-PHF20 translocates to cytosol

Stable Identifier
R-HSA-6805792
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PHF20 phosphorylated at serine S291 by AKT (Park et al. 2012, Li et al. 2013) translocates to the cytosol (Park et al. 2012). AKT thus prevents PHF20-mediated stimulation of TP53 (p53) activity (Park et al. 2012, Li et al. 2013).

Literature References
PubMed ID Title Journal Year
22334668 Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53

Park, S, Kim, D, Dan, HC, Chen, H, Testa, JR, Cheng, JQ

J. Biol. Chem. 2012
22975685 PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage

Li, Y, Park, J, Piao, L, Kong, G, Kim, Y, Park, KA, Zhang, T, Hong, J, Hur, GM, Seok, JH, Choi, SW, Yoo, BC, Hemmings, BA, Brazil, DP, Kim, SH, Park, J

Cell. Signal. 2013
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