S100A1 binds TLR4:LY96

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The human event of S100A1 is inferred from the mouse data.

S100A1 is a Ca(2+)-sensing protein of the EF-hand family. S100A1 is expressed predominantly in cardiomyocytes, where it regulates Ca(2+)-dependent signaling events (Wright NT et al. 2005; Cannon BR et al. 2011; Brinks H et al. 2011; Yu J et al. 2015; Rohde D et al. 2014; Ritterhoff J & Most P 2012). In response to ischemic/hypoxic damage of cardiomyocytes, S100A1 is released or transferred to the extracellular region through open channels on membrane (Rohde D et al. 2014). The extracellular S100A1 activates signal and promotes cell survival pathways, including inflammation response via Toll-like receptor 4 (TLR4) (Brinks H et al. 2011; Yu J et al. 2015; Rohde D et al. 2014). In rodent H9C2 cells S100A1 was found to regulate the inflammatory response and oxidative stress via TLR4/ROS/NFkappaB pathway ( Yu J et al. 2015).

Literature References
PubMed ID Title Journal Year
24833748 S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4

Rohde, D, Schön, C, Boerries, M, Didrihsone, I, Ritterhoff, J, Kubatzky, KF, Völkers, M, Herzog, N, Mähler, M, Tsoporis, JN, Parker, TG, Linke, B, Giannitsis, E, Gao, E, Peppel, K, Katus, HA, Most, P

EMBO Mol Med 2014
25880347 Role of S100A1 in hypoxia-induced inflammatory response in cardiomyocytes via TLR4/ROS/NF-κB pathway

Yu, J, Lu, Y, Li, Y, Xiao, L, Xing, Y, Li, Y, Wu, L

J. Pharm. Pharmacol. 2015
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