Reactome | S100A1 [extracellular region]

S100A1 [extracellular region]

Stable Identifier

R-HSA-6805991

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

S-100 protein alpha chain

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P23297 S100A1

Gene Names

S100A1, S100A

Chain

chain:1-94

Reference Genes

BioGPS Gene:6271 S100A1

COSMIC (genes):S100A1 S100A1

CTD Gene:6271 S100A1

dbSNP Gene:6271 S100A1

ENSEMBL:ENSG00000160678 S100A1

HGNC:10486 S100A1

KEGG Gene (Homo sapiens):6271 S100A1

Monarch:6271 S100A1

NCBI Gene:6271 S100A1

OMIM:176940 S100A1

UCSC:P23297 S100A1

Reference Transcript

RefSeq:NM_006271.1 S100A1

Other Identifiers

0006900594

11725048_a_at

205334_at

2359724

2359725

2359729

2359731

2359732

2359733

34674_at

4043383

4043387

4043390

4043391

6271

7905581

A_23_P383227

A_33_P3409086

GE79119

GO:0000122

GO:0002224

GO:0003013

GO:0003674

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0006810

GO:0007165

GO:0008016

GO:0008150

GO:0009058

GO:0016529

GO:0019899

GO:0021762

GO:0030018

GO:0031430

GO:0031672

GO:0031674

GO:0032991

GO:0034641

GO:0035556

GO:0042802

GO:0042803

GO:0043005

GO:0043167

GO:0043226

GO:0044548

GO:0046872

GO:0048306

GO:0048646

GO:0048856

GO:0051000

GO:0051117

GO:0055085

GO:1901387

GO:1903672

ILMN_1653494

PH_hs_0030180

PH_hs_0033323

X58079_at

g5454031_3p_at

g5454031_3p_x_at

Participant Of

hasComponent

S100A1 dimer:Ca(2+) [extracellular region]

Inferred To

S100a1 [extracellular region] (Mus musculus)

S100A1 [extracellular region] (Gallus gallus)

S100A1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_006262.1

OpenTargets

ENSG00000160678

HPA

ENSG00000160678-S100A1

GeneCards

P23297

Ensembl

ENSG00000160678, ENSP00000292169, ENST00000292169

PRO

P23297

HMDB Protein

HMDBP07980

PDB

2LUX, 5K89, 2LLS, 2M3W, 2L0P, 2LLT, 2LP2, 2LLU, 2LP3, 2LHL

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.966	25
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.623	3
UniProt:P35579 MYH9	1	MYH9 [cytosol] (R-HSA-419173)	0.611	3
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.558	2
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.556	3
UniProt:Q96CV9 OPTN	4	OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525)	0.556	3
UniProt:P52907 CAPZA1	2	CAPZA1 [cytosol] (R-HSA-879363) CAPZA1(265-276) [extracellular region] (R-HSA-879421)	0.544	2

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