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S100A1 [extracellular region]
Stable Identifier
R-HSA-6805991
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
S-100 protein alpha chain
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IRAK4 deficiency (TLR2/4) (Homo sapiens)
Defective IRAK4 does not bind MyD88 within the TLR2/4 complex (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
MyD88 deficiency (TLR2/4) (Homo sapiens)
Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)
MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
IKKB phosphorylates SNAP23 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
S100A1 binds TLR4:LY96 (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
S100A1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23297 S100A1
Gene Names
S100A1, S100A
Chain
chain:1-94
Reference Genes
BioGPS Gene:6271 S100A1
COSMIC (genes):S100A1 S100A1
CTD Gene:6271 S100A1
dbSNP Gene:6271 S100A1
ENSEMBL:ENSG00000160678 S100A1
ENSEMBL:ENSG00000160678.12 S100A1
HGNC:10486 S100A1
KEGG Gene (Homo sapiens):6271 S100A1
Monarch:6271 S100A1
NCBI Gene:6271 S100A1
OMIM:176940 S100A1
UCSC:P23297 S100A1
Reference Transcript
RefSeq:NM_006271.1 S100A1
Other Identifiers
11725048_a_at
205334_PM_at
205334_at
2359724
2359725
2359729
2359731
2359732
2359733
34674_at
4043383
4043387
4043390
4043391
6271
7905581
A_23_P383227
A_33_P3409086
GE79119
GO:0003013
GO:0005509
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005794
GO:0005829
GO:0008016
GO:0016529
GO:0021762
GO:0023052
GO:0032991
GO:0035556
GO:0042802
GO:0042803
GO:0043226
GO:0044548
GO:0046872
GO:0048856
GO:0051000
GO:0051117
GO:1903672
HMNXSV003037658
ILMN_1653494
PH_hs_0030180
PH_hs_0033323
X58079_at
g5454031_3p_at
g5454031_3p_x_at
Participates
as a component of
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Inferred To
S100A1 [extracellular region]
(Bos taurus)
S100A1 [extracellular region]
(Canis familiaris)
S100A1 [extracellular region]
(Gallus gallus)
S100A1 [extracellular region]
(Mus musculus)
S100A1 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_006262.1
OpenTargets
ENSG00000160678
HPA
ENSG00000160678-S100A1
GeneCards
P23297
Ensembl
ENST00000292169
,
ENSG00000160678
,
ENSP00000292169
PRO
P23297
Pharos - Targets
P23297
HMDB Protein
HMDBP07980
PDB
5K89
,
2LLU
,
2LLS
,
2M3W
,
2LHL
,
2LLT
,
2LP3
,
2L0P
,
2LP2
,
2LUX
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.966
25
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.623
3
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.611
3
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.558
2
UniProt:Q00994 BEX3
1
NGFRAP1 [cytosol]
(R-HSA-194333)
0.556
3
UniProt:Q96CV9 OPTN
5
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
0.556
3
UniProt:P52907 CAPZA1
2
CAPZA1(265-276) [extracellular region]
(R-HSA-879421)
CAPZA1 [cytosol]
(R-HSA-879363)
0.544
2
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