Reactome | S100A1 [extracellular region]

S100A1 [extracellular region]

Stable Identifier

R-HSA-6805991

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

S-100 protein alpha chain

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of Immune System (Homo sapiens)
  - Diseases associated with the TLR signaling cascade (Homo sapiens)
    - IRAK4 deficiency (TLR2/4) (Homo sapiens)
      - Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
    - MyD88 deficiency (TLR2/4) (Homo sapiens)
      - Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
      - Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)
        
        MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing-Cross presentation (Homo sapiens)
      - ER-Phagosome pathway (Homo sapiens)
        
        IKKB phosphorylates SNAP23 (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Regulation of TLR by endogenous ligand (Homo sapiens)
      - S100A1 binds TLR4:LY96 (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
        
        TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
        
        TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
        
        TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
        
        IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
        
        IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Multiple IRAK1 autophosphorylation steps (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
        
        MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
        
        MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
        
        IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TIRAP is phosphorylated by BTK (Homo sapiens)
        
        TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TRAF6 binds to hp- IRAK1 (Homo sapiens)
        
        TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TRAF6 binds to p-IRAK2 (Homo sapiens)
        
        TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
        
        TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
        
        TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
        
        TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
        
        IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
        
        IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Multiple IRAK1 autophosphorylation steps (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
        
        MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
        
        MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
        
        IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TIRAP is phosphorylated by BTK (Homo sapiens)
        
        TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TRAF6 binds to hp- IRAK1 (Homo sapiens)
        
        TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TRAF6 binds to p-IRAK2 (Homo sapiens)
        
        TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
        
        TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
        
        TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
        
        TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
        
        IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
        
        IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Multiple IRAK1 autophosphorylation steps (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
        
        MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
        
        MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
        
        IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TIRAP is phosphorylated by BTK (Homo sapiens)
        
        TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TRAF6 binds to hp- IRAK1 (Homo sapiens)
        
        TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        TRAF6 binds to p-IRAK2 (Homo sapiens)
        
        TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
        
        activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
        
        Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
        
        TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
        
        S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
        
        S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
        
        S100A1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23297 S100A1

Gene Names

S100A1, S100A

Chain

chain:1-94

Reference Genes

BioGPS Gene:6271 S100A1

COSMIC (genes):S100A1 S100A1

CTD Gene:6271 S100A1

dbSNP Gene:6271 S100A1

ENSEMBL:ENSG00000160678 S100A1

ENSEMBL_homo_sapiens_GENE:ENSG00000160678.12 S100A1

HGNC:10486 S100A1

KEGG Gene (Homo sapiens):6271 S100A1

Monarch:6271 S100A1

NCBI Gene:6271 S100A1

OMIM:176940 S100A1

UCSC:P23297 S100A1

Reference Transcript

RefSeq:NM_006271.1 S100A1

Other Identifiers

11725048_a_at

205334_PM_at

205334_at

2359724

2359725

2359729

2359731

2359732

2359733

34674_at

4043383

4043387

4043390

4043391

6271

7905581

A_23_P383227

A_33_P3409086

GE79119

GO:0003013

GO:0005509

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005783

GO:0005794

GO:0005829

GO:0008016

GO:0016529

GO:0021762

GO:0023052

GO:0032991

GO:0035556

GO:0042802

GO:0042803

GO:0043226

GO:0044548

GO:0046872

GO:0048306

GO:0048856

GO:0051000

GO:0051117

GO:1903672

HMNXSV003037658

ILMN_1653494

PH_hs_0030180

PH_hs_0033323

X58079_at

g5454031_3p_at

g5454031_3p_x_at

Participates

as a component of

S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)

Inferred To

S100A1 [extracellular region] (Bos taurus)

S100A1 [extracellular region] (Canis familiaris)

S100A1 [extracellular region] (Gallus gallus)

S100A1 [extracellular region] (Mus musculus)

S100A1 [extracellular region] (Rattus norvegicus)

S100A1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_006262.1

OpenTargets

ENSG00000160678

HPA

ENSG00000160678-S100A1

GeneCards

P23297

Ensembl

ENSG00000160678, ENST00000292169, ENSP00000292169

PRO

P23297

Pharos - Targets

P23297

HMDB Protein

HMDBP07980

PDB

2LLS, 2LP3, 2LUX, 2LP2, 2LHL, 2L0P, 5K89, 2LLU, 2M3W, 2LLT

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.966	25
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.623	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.611	3
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.558	2
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.556	3
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.556	3
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.544	2

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