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MME [secretory granule membrane]
Stable Identifier
R-HSA-6806156
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule membrane
Synonyms
Neprilysin, NEP_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
MME [secretory granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08473 MME
Gene Names
MME, EPN
Chain
initiator methionine:1, chain:2-750
Reference Genes
BioGPS Gene:4311 MME
COSMIC (genes):MME MME
CTD Gene:4311 MME
dbSNP Gene:4311 MME
ENSEMBL:ENSG00000196549 MME
HGNC:7154 MME
KEGG Gene (Homo sapiens):4311 MME
Monarch:4311 MME
NCBI Gene:4311 MME
OMIM:120520 MME
UCSC:P08473 MME
Reference Transcript
RefSeq:NM_007288.2 MME
RefSeq:NM_000902.3 MME
RefSeq:XM_011512856.2 MME
RefSeq:NM_007289.2 MME
RefSeq:XM_011512857.2 MME
RefSeq:XM_006713647.3 MME
RefSeq:XM_006713646.3 MME
RefSeq:NM_007287.2 MME
RefSeq:XM_011512855.2 MME
Other Identifiers
0003800692
0004050014
0005890619
0006770279
11720022_a_at
11741562_a_at
11747693_a_at
11755860_a_at
13
1389_at
16947173
1DL9
1DMT
1QVD
1R1H
1R1I
1R1J
1Y8J
203434_s_at
203435_s_at
2648678
2648679
2648680
2648681
2648682
2648683
2648686
2648687
2648688
2648705
2648707
2648708
2648709
2648710
2648715
2648716
2648717
2648718
2648720
2648721
2648724
2648725
2648727
2648729
2648731
2648732
2648734
2648736
2648742
2648743
2648744
2648745
2648746
2QPJ
2YB9
4311
4CTH
52583
56072
5JMY
6GID
8083494
A0A087WWM7
A_14_P114532
A_23_P212061
A_24_P260101
A_33_P3290707
A_33_P3370094
AAA51915
AAA52294
AAI01633
AAI01659
ACA05913
AK291761
BAF84450
BC101632
BC101658
C9IYX7
C9J9X7
C9JDZ3
C9JR96
CAA30157
CAA68752
CAB000013
CCDS3172
CH471052
EAW78754
EAW78755
EAW78756
EAW78757
EAW78758
ENSG00000196549
ENSP00000353679
ENSP00000417079
ENSP00000418525
ENSP00000419653
ENSP00000420389
ENSP00000478173
ENST00000360490
ENST00000360490.6
ENST00000460393
ENST00000460393.5
ENST00000462745
ENST00000462745.5
ENST00000492661
ENST00000492661.5
ENST00000493237
ENST00000493237.5
ENST00000615825
ENST00000615825.1
EntrezGene:4311
EntrezGene:MME
EU326307
g6042199_3p_a_at
GE58450
GO:0000003
GO:0001786
GO:0001822
GO:0001890
GO:0002003
GO:0002376
GO:0003013
GO:0003674
GO:0004175
GO:0004222
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005768
GO:0005769
GO:0005794
GO:0005802
GO:0005886
GO:0005887
GO:0005903
GO:0005925
GO:0006508
GO:0006518
GO:0006810
GO:0007267
GO:0007568
GO:0007611
GO:0008021
GO:0008150
GO:0008233
GO:0008237
GO:0008238
GO:0008270
GO:0008289
GO:0009056
GO:0009986
GO:0016020
GO:0016021
GO:0016192
GO:0016787
GO:0019233
GO:0030154
GO:0030324
GO:0030424
GO:0030425
GO:0030667
GO:0031410
GO:0034641
GO:0042277
GO:0042803
GO:0043025
GO:0043167
GO:0043226
GO:0043312
GO:0044281
GO:0044306
GO:0045121
GO:0045202
GO:0046449
GO:0046872
GO:0048856
GO:0050435
GO:0050769
GO:0050877
GO:0051604
GO:0061837
GO:0070012
GO:0070062
GO:0071345
GO:0071492
GO:0071493
GO:0090399
GO:0097242
GO:0098793
GO:0150094
GO:1900273
GO:1901612
HGNC:7154
HPA052583
HPA056072
Hs.1298.2.S1_3p_a_at
ILMN_1671073
ILMN_1678170
ILMN_1696162
ILMN_1751943
ILMN_1786319
IPR000718
IPR008753
IPR018497
IPR024079
IPR029727
IPR042089
J03779
J03779_at
M26607
M26608
M26609
M26610
M26611
M26612
M26613
M26614
M26615
M26616
M26617
M26618
M26619
M26620
M26621
M26622
M26623
M26624
M26625
M26626
M26627
M26628
MIM:120520
MIM:617017
MIM:617018
MME
MME-201
MME-203
MME-204
MME-211
MME-212
MME-216
NM_000902
NM_001354642
NM_001354643
NM_007287
NM_007288
NM_007289
NP_000893
NP_001341571
NP_001341572
NP_009218
NP_009219
NP_009220
PF01431
PF05649
PH_hs_0023672
PR00786
Q3KQS6
TC03000846.hg
UPI0000033C41
X07166
XM_006713647
XM_011512856
XM_011512857
XP_006713710
XP_011511158
XP_011511159
Y00811
Participant Of
hasMember
Secretory granule membrane proteins [secretory granule membrane]
Other forms of this molecule
MME [plasma membrane]
Inferred To
MME [secretory granule membrane] (Bos taurus)
MME [secretory granule membrane] (Caenorhabditis elegans)
MME [secretory granule membrane] (Canis familiaris)
MME [secretory granule membrane] (Drosophila melanogaster)
MME [secretory granule membrane] (Gallus gallus)
MME [secretory granule membrane] (Mus musculus)
MME [secretory granule membrane] (Rattus norvegicus)
MME [secretory granule membrane] (Xenopus tropicalis)
Homologues of MME [secretory granule membrane] (Caenorhabditis elegans)
Homologues of MME [secretory granule membrane] (Drosophila melanogaster)
Cross References
RefSeq
XP_011511158.1
,
XP_006713710.1
,
XP_006713709.1
,
NP_009220.2
,
NP_000893.2
,
NP_009219.2
,
NP_009218.2
,
XP_011511157.1
,
XP_011511159.1
ZINC - World Drugs
NEP_HUMAN
OpenTargets
ENSG00000196549
ZINC - Substances
NEP_HUMAN
ZINC target
P08473
ZINC - Biogenic
NEP_HUMAN
PRO
P08473
PDB
6SH1
,
6GID
,
2YB9
,
1R1I
,
1DL9
,
1DMT
,
1R1J
,
1QVD
,
1Y8J
,
4CTH
,
6SH2
,
2QPJ
,
5JMY
,
1R1H
ZINC - Investigational
NEP_HUMAN
ZINC - Metabolites
NEP_HUMAN
GeneCards
P08473
ZINC - Predictions - Purchasable
NEP_HUMAN
Orphanet
23768
HMDB Protein
HMDBP02539
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.537
4
UniProt:P08107 HSP71
0.499
3
UniProt:P21926 CD9
4
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.499
6
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