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IMPDH1 [extracellular region]
Stable Identifier
R-HSA-6806182
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IMP (inosine monophosphate) dehydrogenase 1, Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1), Inosine-5'-monophosphate dehydrogenase 1 , IMP dehydrogenase 1, IMPDH-I, IMPD 1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
IMPDH1 [extracellular region] (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
IMPDH1 [extracellular region] (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
IMPDH1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20839 IMPDH1
Gene Names
IMPDH1, IMPD1
Chain
initiator methionine:1, chain:2-514
Reference Genes
BioGPS Gene:3614 IMPDH1
COSMIC (genes):IMPDH1 IMPDH1
CTD Gene:3614 IMPDH1
dbSNP Gene:3614 IMPDH1
ENSEMBL:ENSG00000106348 IMPDH1
HGNC:6052 IMPDH1
KEGG:hsa:3614 IMPDH1
Monarch:3614 IMPDH1
NCBI Gene:3614 IMPDH1
OMIM:146690 IMPDH1
UCSC:P20839 IMPDH1
Reference Transcript
RefSeq:NM_000883.3 IMPDH1
RefSeq:NM_001142573.2 IMPDH1
RefSeq:NM_001142576.2 IMPDH1
RefSeq:NM_001142575.2 IMPDH1
RefSeq:NM_001102605.2 IMPDH1
RefSeq:XM_017012172.1 IMPDH1
RefSeq:NM_001142574.2 IMPDH1
RefSeq:NM_001304521.1 IMPDH1
RefSeq:NM_183243.3 IMPDH1
Participates
as a member of
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
IMPDH1 [cytosol]
IMPDH1 [azurophil granule lumen]
IMPDH1 [secretory granule lumen]
IMPDH1 [ficolin-1-rich granule lumen]
Inferred To
Impdh1 [extracellular region]
(Mus musculus)
Impdh1 [extracellular region]
(Rattus norvegicus)
IMD2 [extracellular region]
(Saccharomyces cerevisiae)
IMD3 [extracellular region]
(Saccharomyces cerevisiae)
impdh [extracellular region]
(Dictyostelium discoideum)
impdh1a [extracellular region]
(Danio rerio)
impdh1 [extracellular region]
(Xenopus tropicalis)
IMPDH1 [extracellular region]
(Bos taurus)
IMPDH1 [extracellular region]
(Caenorhabditis elegans)
IMPDH1 [extracellular region]
(Canis familiaris)
IMPDH1 [extracellular region]
(Plasmodium falciparum)
IMPDH1 [extracellular region]
(Sus scrofa)
Homologues of IMPDH1 [extracellular region]
(Saccharomyces cerevisiae)
ras [extracellular region]
(Drosophila melanogaster)
gua1 [extracellular region]
(Schizosaccharomyces pombe)
IMD4 [extracellular region]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001136046.1
,
NP_001136047.1
,
NP_001136048.1
,
NP_001136045.1
,
XP_016867661.1
,
NP_001291450.1
,
NP_000874.2
,
NP_001096075.1
,
NP_899066.1
ZINC - World Drugs
IMDH1_HUMAN
Guide to Pharmacology - Targets
2624
OpenTargets
ENSG00000106348
ENSEMBL
ENST00000419067
,
ENSP00000399400
,
ENSP00000420185
,
ENSG00000106348
,
ENST00000496200
,
ENST00000480861
,
ENST00000354269
,
ENSP00000346219
,
ENST00000348127
,
ENSP00000345096
,
ENSP00000265385
,
ENST00000338791
,
ENSP00000420803
ZINC - FDA approved
IMDH1_HUMAN
ZINC - Substances
IMDH1_HUMAN
ZINC - Biogenic
IMDH1_HUMAN
ZINC target
P20839
PRO
P20839
GlyGen
P20839
PDB
8U8O
,
7RFH
,
8U7V
,
8U8Y
,
8U7Q
,
7RFG
,
7RFI
,
7RGI
,
7RGL
,
7RER
,
1JCN
,
7RGM
,
7RES
,
7RGQ
,
7RFF
,
8U7M
,
7RFE
,
7RGD
IntEnz
1.1.1.205
HPA
ENSG00000106348-IMPDH1
GeneCards
IMPDH1
Pharos - Targets
P20839
Orphanet
IMPDH1
ZINC - Predictions - Purchasable
IMDH1_HUMAN
HMDB Protein
HMDBP00883
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96EF0 MTMR8
1
MTMR8 [cytosol]
(R-HSA-1604671)
0.527
3
UniProt:Q9H2D1 SLC25A32
1
SLC25A32 [mitochondrial inner membrane]
(R-HSA-200645)
0.527
2
UniProt:Q14527 HLTF
1
HLTF [nucleoplasm]
(R-HSA-8855007)
0.527
2
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.527
4
UniProt:Q8WVC6 DCAKD
1
DCAKD [mitochondrial outer membrane]
(R-HSA-9837353)
0.527
4
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