Reactome | FRK [extracellular region]

FRK [extracellular region]

Stable Identifier

R-HSA-6806235

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Tyrosine-protein kinase FRK ecNumber2.7.10.2/ecNumber, FRK_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P42685 FRK

Gene Names

FRK, PTK5, RAK

Chain

chain:1-505

Reference Genes

BioGPS Gene:2444 FRK

COSMIC (genes):FRK FRK

CTD Gene:2444 FRK

dbSNP Gene:2444 FRK

ENSEMBL:ENSG00000111816 FRK

HGNC:3955 FRK

KEGG Gene (Homo sapiens):2444 FRK

Monarch:2444 FRK

NCBI Gene:2444 FRK

OMIM:606573 FRK

UCSC:P42685 FRK

Reference Transcript

Other Identifiers

0006290128

04660+2.7.10.2

11740398_a_at

11750652_a_at

11751533_a_at

17022916

207178_s_at

235924_at

2444

25217

2970898

2970899

2970900

2970901

2970902

2970903

2970904

2970905

2970906

2970907

2970915

2970926

2970927

2970929

2970931

2970933

30479

35023_at

46333_r_at

511_s_at

8129071

A_23_P133665

A_32_P23525

AAA18284

AAC50116

AAH12916

AK302264

AL021451

AL121963

AL357141

BAG63611

BC012916

CAB025217

CCDS5103

CH471051

EAW48241

ENSG00000111816

ENSP00000476145

ENST00000606080

ENST00000606080.1

EntrezGene:2444

EntrezGene:FRK

FRK

FRK-201

g4503786_3p_a_at

GE536600

GE58839

GO:0000122

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006810

GO:0007165

GO:0007169

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0030154

GO:0031234

GO:0031410

GO:0034641

GO:0035578

GO:0035580

GO:0038083

GO:0042127

GO:0043167

GO:0043226

GO:0043312

GO:0070062

HGNC:3955

HPA030479

Hs.36288.0.A1_3p_at

ILMN_1727605

IPR000719

IPR000980

IPR001245

IPR001452

IPR008266

IPR011009

IPR017441

IPR020635

IPR035805

IPR036028

IPR036860

MIM:606573

NM_002031

NP_002022

PF00017

PF00018

PF07714

PH_hs_0004981

PR00109

PR00401

PR00452

SM00219

SM00252

SM00326

TC06002043.hg

U00803

U22322

U22322_s_at

UPI000012AC35

XM_005266880

XM_005266881

XM_005266882

XM_011535653

XM_011535654

XM_011535655

XM_011535656

XM_017010645

XP_005266937

XP_005266938

XP_005266939

XP_011533955

XP_011533956

XP_011533957

XP_011533958

XP_016866134

Participant Of

hasMember

Other forms of this molecule

p-Y387-FRK [cytosol]

FRK [specific granule lumen]

FRK [azurophil granule lumen]

Inferred To

FRK [extracellular region] (Bos taurus)

FRK [extracellular region] (Caenorhabditis elegans)

FRK [extracellular region] (Canis familiaris)

FRK [extracellular region] (Danio rerio)

FRK [extracellular region] (Drosophila melanogaster)

FRK [extracellular region] (Gallus gallus)

FRK [extracellular region] (Mus musculus)

FRK [extracellular region] (Rattus norvegicus)

FRK [extracellular region] (Sus scrofa)

FRK [extracellular region] (Xenopus tropicalis)

Cross References

ZINC - Investigational

FRK_HUMAN

RefSeq

NP_002022.1, XP_005266939.1, XP_011533955.1, XP_005266937.1, XP_011533957.1, XP_005266938.1, XP_016866134.1, XP_011533956.1

ZINC - World Drugs

FRK_HUMAN

OpenTargets

ENSG00000111816

ZINC - FDA approved

FRK_HUMAN

ZINC - Substances

FRK_HUMAN

GeneCards

P42685

ZINC - Biogenic

FRK_HUMAN

ZINC target

P42685

PRO

P42685

ZINC - Predictions - Purchasable

FRK_HUMAN

HMDB Protein

HMDBP01478

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.742	5
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.666	4
UniProt:P60484 PTEN	122	PTEN [nucleoplasm] (R-HSA-5690148) K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379) PTEN C124Y [cytosol] (R-HSA-2317464) PTEN R130P [cytosol] (R-HSA-2317432) PTEN C124F [cytosol] (R-HSA-2317461) PTEN G129V [cytosol] (R-HSA-2318503) PTEN S170I [cytosol] (R-HSA-2318455) PTEN S170G [cytosol] (R-HSA-2318465) PTEN E99* [cytosol] (R-HSA-9659052) PTEN G165* [cytosol] (R-HSA-9659117) PTEN E157* [cytosol] (R-HSA-9658926) PTEN E150* [cytosol] (R-HSA-9658920) PTEN E43* [cytosol] (R-HSA-9659049) PTEN Q17* [cytosol] (R-HSA-9659305) PTEN E91* [cytosol] (R-HSA-9659050) PTEN S59* [cytosol] (R-HSA-9659360) PTEN E114* [cytosol] (R-HSA-9658915) PTEN L139* [cytosol] (R-HSA-9659196) PTEN Y176* [cytosol] (R-HSA-9659389) PTEN Y177* [cytosol] (R-HSA-9659390) PTEN Q149* [cytosol] (R-HSA-9659320) PTEN L146* [cytosol] (R-HSA-9659193) PTEN G20* [cytosol] (R-HSA-9659129) PTEN G127* [cytosol] (R-HSA-9659130) PTEN Y46* [cytosol] (R-HSA-9659387) PTEN L182* [cytosol] (R-HSA-9659189) PTEN Q97* [cytosol] (R-HSA-9659318) PTEN Q171* [cytosol] (R-HSA-9659312) PTEN G129* [cytosol] (R-HSA-9659120) PTEN E18* [cytosol] (R-HSA-9658931) PTEN Y180* [cytosol] (R-HSA-9659404) PTEN K163* [cytosol] (R-HSA-9659148) PTEN Y27* [cytosol] (R-HSA-9659405) PTEN Y65* [cytosol] (R-HSA-9659406) PTEN Y68* [cytosol] (R-HSA-9659400) PTEN K128* [cytosol] (R-HSA-9659145) PTEN Y138* [cytosol] (R-HSA-9659402) PTEN K125* [cytosol] (R-HSA-9659147) PTEN Y88* [cytosol] (R-HSA-9659399) PTEN Q110* [cytosol] (R-HSA-9659328) PTEN L23* [cytosol] (R-HSA-9659201) PTEN E7* [cytosol] (R-HSA-9659036) PTEN C105* [cytosol] (R-HSA-9658911) PTEN E73* [cytosol] (R-HSA-9659039) PTEN K62* [cytosol] (R-HSA-9659160) PTEN E40* [cytosol] (R-HSA-9659032) PTEN Y178* [cytosol] (R-HSA-9659417) PTEN R130* [cytosol] (R-HSA-2318571) PTEN W111* [cytosol] (R-HSA-9659414) PTEN R11* [cytosol] (R-HSA-9659350) PTEN K13* [cytosol] (R-HSA-9659152) PTEN Y174* [cytosol] (R-HSA-9659409) PTEN K147* [cytosol] (R-HSA-9659153) PTEN R84* [cytosol] (R-HSA-9659347) PTEN G293* [cytosol] (R-HSA-9659113) PTEN S287* [cytosol] (R-HSA-9659371) PTEN Q214* [cytosol] (R-HSA-9659307) PTEN S229* [cytosol] (R-HSA-9659366) PTEN Q219* [cytosol] (R-HSA-9659302) PTEN Q261* [cytosol] (R-HSA-9659303) PTEN E299* [cytosol] (R-HSA-9659040) PTEN Y336* [cytosol] (R-HSA-9659388) PTEN Q245* [cytosol] (R-HSA-9659326) PTEN Y225* [cytosol] (R-HSA-9659391) PTEN Y240* [cytosol] (R-HSA-9659385) PTEN C218* [cytosol] (R-HSA-9659065) PTEN C250* [cytosol] (R-HSA-9659066) PTEN L247* [cytosol] (R-HSA-9659195) PTEN G209* [cytosol] (R-HSA-9659124) PTEN C211* [cytosol] (R-HSA-9659062) PTEN G230* [cytosol] (R-HSA-9659121) PTEN Q298* [cytosol] (R-HSA-9659314) PTEN L320* [cytosol] (R-HSA-9659187) PTEN E242* [cytosol] (R-HSA-9659084) PTEN K332* [cytosol] (R-HSA-9659151) PTEN E284* [cytosol] (R-HSA-9659087) PTEN E291* [cytosol] (R-HSA-9659081) PTEN K330* [cytosol] (R-HSA-9659146) PTEN E314* [cytosol] (R-HSA-9659078) PTEN Y346* [cytosol] (R-HSA-9659392) PTEN C296* [cytosol] (R-HSA-9659072) PTEN W274* [cytosol] (R-HSA-9659393) PTEN R233* [cytosol] (R-HSA-2318573) PTEN R335* [cytosol] (R-HSA-2318568) PTEN E256* [cytosol] (R-HSA-9659098) PTEN R189* [cytosol] (R-HSA-9659354) PTEN E307* [cytosol] (R-HSA-9659099) PTEN K263* [cytosol] (R-HSA-9659156) PTEN E235* [cytosol] (R-HSA-9659029) PTEN E288* [cytosol] (R-HSA-9659094) PTEN K221* [cytosol] (R-HSA-9659158) PTEN K344* [cytosol] (R-HSA-9659159) p-Y336-PTEN [cytosol] (R-HSA-8847980) PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (R-HSA-8948841) RibC-E40,E150,D326-PTEN [cytosol] (R-HSA-8948798) p-3S,2T-PTEN [cytosol] (R-HSA-8850936) PTEN [cytosol] (R-HSA-199420) PTEN [nucleoplasm] (R-HSA-6807273) MonoUb-K13,K289-PTEN [nucleoplasm] (R-HSA-6807264) MonoUb-K13,K289-PTEN [cytosol] (R-HSA-6807247) K48polyUb-K289-PTEN [cytosol] (R-HSA-8948777) PolyUb-PTEN [cytosol] (R-HSA-6807280) K27polyUb-PTEN [cytosol] (R-HSA-8851009)	0.639	7
UniProt:P06400 RB1	3	p-S795-RB1 [nucleoplasm] (R-HSA-69226) RB1 [nucleoplasm] (R-HSA-68642) p-RB1 [nucleoplasm] (R-HSA-188389)	0.544	3
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.527	2