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MAPK1 [extracellular region]
Stable Identifier
R-HSA-6806250
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
ERK2, Mitogen-activated protein kinase 1 (EC 2.7.1.-) (Extracellular signal- regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1), Mitogen-activated protein kinase 1 , Extracellular signal-regulated kinase 2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1, ERK-2
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
MAPK1 [extracellular region] (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
MAPK1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P28482 MAPK1
Gene Names
MAPK1, ERK2, PRKM1, PRKM2
Chain
initiator methionine:, chain:2-360
Reference Genes
BioGPS Gene:5594 MAPK1
COSMIC (genes):MAPK1 MAPK1
CTD Gene:5594 MAPK1
dbSNP Gene:5594 MAPK1
ENSEMBL:ENSG00000100030 MAPK1
ENSEMBL_homo_sapiens_GENE:ENSG00000100030.15 MAPK1
HGNC:6871 MAPK1
KEGG Gene (Homo sapiens):5594 MAPK1
Monarch:5594 MAPK1
NCBI Gene:5594 MAPK1
OMIM:176948 MAPK1
UCSC:P28482 MAPK1
Reference Transcript
RefSeq:NM_002745.4 MAPK1
RefSeq:NM_138957.3 MAPK1
Other Identifiers
11715841_at
11715842_a_at
11715843_at
11738871_a_at
11738872_x_at
11751223_a_at
11751224_x_at
11753379_a_at
1552263_PM_at
1552263_at
1552264_PM_a_at
1552264_a_at
16932831
208351_PM_s_at
208351_s_at
212271_PM_at
212271_at
224621_PM_at
224621_at
3954239
3954240
3954241
3954242
3954243
3954244
3954245
3954246
3954248
3954249
3954252
3954256
3954257
3954261
3954262
3954264
3954266
3954273
3954274
45715_at
55528_at
5594
8074791
976_s_at
A_23_P257895
A_24_P237265
GE476071
GE534117
GE56878
GE86009
GO:0000165
GO:0000166
GO:0001784
GO:0002376
GO:0003677
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0006915
GO:0006935
GO:0006974
GO:0007010
GO:0007049
GO:0007165
GO:0007166
GO:0007268
GO:0007507
GO:0007611
GO:0008286
GO:0008353
GO:0009887
GO:0010759
GO:0010800
GO:0012501
GO:0014032
GO:0014044
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019858
GO:0019902
GO:0023052
GO:0030154
GO:0030278
GO:0030521
GO:0030641
GO:0030878
GO:0031143
GO:0031410
GO:0031647
GO:0031663
GO:0032200
GO:0032212
GO:0032496
GO:0032872
GO:0033554
GO:0033598
GO:0034198
GO:0034614
GO:0035094
GO:0035556
GO:0035578
GO:0036211
GO:0038127
GO:0038133
GO:0042473
GO:0042552
GO:0042802
GO:0043226
GO:0043330
GO:0043401
GO:0045202
GO:0045596
GO:0048009
GO:0048538
GO:0048856
GO:0048870
GO:0050847
GO:0050852
GO:0050853
GO:0050877
GO:0051403
GO:0051493
GO:0051973
GO:0055086
GO:0060020
GO:0060291
GO:0060324
GO:0060425
GO:0060440
GO:0060716
GO:0061308
GO:0070161
GO:0070371
GO:0070849
GO:0071276
GO:0071356
GO:0072584
GO:0072686
GO:0090170
GO:0106310
GO:0120041
GO:0140096
GO:1904355
GO:1904813
GO:2000641
HMNXSV003015938
HMNXSV003030947
Hs.324473.2.S1_3p_at
Hs.66151.0.S1_3p_at
Hs2.324473.2.S1_3p_at
ILMN_1706677
ILMN_1767320
ILMN_2235283
PH_hs_0016141
PH_hs_0039033
TC22000547.hg
Z11695_at
g4506086_3p_a_at
Participates
as a member of
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
MAPK1 [endoplasmic reticulum lumen]
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [azurophil granule lumen]
p-T185,Y187 MAPK1 E322V [cytosol]
p-T185,Y187 MAPK1 E322K [cytosol]
p-T185,Y187 MAPK1 E81K [cytosol]
p-T185,Y187 MAPK1 S142L [cytosol]
p-T185,Y187 MAPK1 P58L [cytosol]
p-T185,Y187 MAPK1 D321V [cytosol]
p-T185,Y187 MAPK1 D321N [cytosol]
p-T185,Y187 MAPK1 E322A [cytosol]
p-T185,Y187 MAPK1 P58G [cytosol]
p-T185-MAPK1 [cytosol]
MAPK1 [nucleoplasm]
MAPK1 [cytosol]
p-T185,Y187-MAPK1 [cytosol]
p-T185,Y187-MAPK1 [nucleoplasm]
Inferred To
Homologues of MAPK1 [extracellular region]
(Saccharomyces cerevisiae)
Homologues of MAPK1 [extracellular region]
(Schizosaccharomyces pombe)
MAPK1 [extracellular region]
(Bos taurus)
MAPK1 [extracellular region]
(Caenorhabditis elegans)
MAPK1 [extracellular region]
(Canis familiaris)
MAPK1 [extracellular region]
(Danio rerio)
MAPK1 [extracellular region]
(Dictyostelium discoideum)
MAPK1 [extracellular region]
(Drosophila melanogaster)
MAPK1 [extracellular region]
(Gallus gallus)
MAPK1 [extracellular region]
(Mus musculus)
MAPK1 [extracellular region]
(Plasmodium falciparum)
MAPK1 [extracellular region]
(Rattus norvegicus)
MAPK1 [extracellular region]
(Saccharomyces cerevisiae)
MAPK1 [extracellular region]
(Schizosaccharomyces pombe)
MAPK1 [extracellular region]
(Sus scrofa)
MAPK1 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002736.3
,
NP_620407.1
ZINC - World Drugs
MK01_HUMAN
Guide to Pharmacology - Targets
1495
OpenTargets
ENSG00000100030
ZINC - FDA approved
MK01_HUMAN
ZINC - Substances
MK01_HUMAN
ZINC target
P28482
ZINC - Biogenic
MK01_HUMAN
PRO
P28482
PDB
5AX3
,
5WP1
,
3TEI
,
6G9M
,
6QA4
,
7NR9
,
3I5Z
,
4O6E
,
6QA3
,
3W55
,
8AOH
,
6G9A
,
8AO6
,
4FV7
,
4NIF
,
6DMG
,
8AOG
,
4ZZO
,
2OJJ
,
5V60
,
2Y9Q
,
5BVD
,
4FV9
,
5K4I
,
7NR3
,
4FMQ
,
5NHH
,
7W5O
,
4FUY
,
4QTE
,
6G9D
,
3SA0
,
8AO7
,
5LCJ
,
3D44
,
6G9J
,
7NR5
,
6G92
,
4FV2
,
5LCK
,
8AOE
,
6G9N
,
6Q7K
,
5NHO
,
4FV4
,
4IZ7
,
5BUJ
,
4QP8
,
7XC1
,
6QAW
,
2OJI
,
4H3Q
,
7OPM
,
6Q7S
,
5V62
,
8AO5
,
8AOF
,
6NBS
,
8AO4
,
1TVO
,
6QAL
,
4G6O
,
6G9H
,
6G91
,
4FV1
,
6GDM
,
4QP2
,
4QP3
,
1PME
,
5NHL
,
6D5Y
,
6GE0
,
6GDQ
,
6QAQ
,
5BVF
,
6OPI
,
4ZZM
,
4QP7
,
8AO3
,
3I60
,
8AOD
,
8AO2
,
6G93
,
4ZZN
,
8AOC
,
6OPH
,
4FV6
,
4IZA
,
4QTA
,
7X4U
,
6GJD
,
7NQW
,
5NHF
,
4QPA
,
4FV8
,
6QAH
,
6QAG
,
1WZY
,
4XJ0
,
6Q7T
,
6GJB
,
7NQQ
,
6OPG
,
8AOB
,
3D42
,
6QA1
,
8AOA
,
4IZ5
,
4FV3
,
7E73
,
6G97
,
7AUV
,
5NHP
,
4QP9
,
4ZXT
,
5BUI
,
2OJG
,
4FV5
,
4N0S
,
4H3P
,
5V61
,
5NHV
,
6RQ4
,
5NGU
,
6SLG
,
7E75
,
4QP1
,
4G6N
,
8AO9
,
8AOJ
,
4FV0
,
8AO8
,
8U8J
,
8AOI
,
4FUX
,
6G54
,
8U8K
,
7NR8
,
5NHJ
,
4QP4
,
5BVE
,
6G9K
,
6G8X
,
4QP6
,
5BUE
ZINC - Investigational
MK01_HUMAN
ZINC - Metabolites
MK01_HUMAN
IntEnz
2.7.11.24
GeneCards
P28482
HPA
ENSG00000100030-MAPK1
Ensembl
ENSP00000215832
,
ENSP00000440842
,
ENST00000398822
,
ENSP00000381803
,
ENSG00000100030
,
ENST00000215832
,
ENST00000544786
Pharos - Targets
P28482
Orphanet
17413
ZINC - Predictions - Purchasable
MK01_HUMAN
HMDB Protein
HMDBP01190
Interactors (61)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15349 RPS6KA2
7
RPS6KA2 [nucleoplasm]
(R-HSA-199861)
p-4S,T356,T570-RPS6KA2 [nucleoplasm]
(R-HSA-199871)
RPS6KA2 [cytosol]
(R-HSA-444252)
p-T356,S360,T570-RPS6KA2 [cytosol]
(R-HSA-9619955)
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(R-HSA-9619869)
p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(R-HSA-9619984)
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]
(R-HSA-444290)
0.914
12
UniProt:Q15418 RPS6KA1
7
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
0.896
12
UniProt:P51812 RPS6KA3
7
RPS6KA3 [nucleoplasm]
(R-HSA-199869)
p-4S,T231,T365-RPS6KA3 [nucleoplasm]
(R-HSA-199830)
RPS6KA3 [cytosol]
(R-HSA-444250)
p-T365,S369,T577-RPS6KA3 [cytosol]
(R-HSA-9619959)
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
(R-HSA-9619872)
p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
(R-HSA-9619989)
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm]
(R-HSA-444286)
0.878
12
UniProt:Q9BUB5 MKNK1
1
p-T250,T255,T385,S437-MKNK1 [cytosol]
(R-HSA-947860)
0.818
11
UniProt:Q13115 DUSP4
1
DUSP4 [nucleoplasm]
(R-HSA-203794)
0.806
6
UniProt:P27361 MAPK3
6
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [nucleoplasm]
(R-HSA-73724)
MAPK3 [cytosol]
(R-HSA-59284)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
0.774
8
UniProt:P35236 PTPN7
2
PTPN7 [nucleoplasm]
(R-HSA-9008913)
PTPN7 [cytosol]
(R-HSA-9635737)
0.767
6
UniProt:Q16828 DUSP6
2
DUSP6 [cytosol]
(R-HSA-5675343)
DUSP6 [nucleoplasm]
(R-HSA-2871619)
0.758
5
UniProt:Q15121 PEA15
1
PEA15 [cytosol]
(R-HSA-5675204)
0.75
5
UniProt:Q99956 DUSP9
1
DUSP9 [cytosol]
(R-HSA-5675351)
0.738
5
UniProt:P0A2M9 SPVC
0.683
3
UniProt:Q15256 PTPRR
0.682
4
UniProt:Q8VSP9 OSPF
0.672
5
UniProt:A2A3K4 PTPC1
0.666
4
UniProt:Q9BRK4 LZTS2
0.666
4
UniProt:P49366 DHPS
1
DHPS [cytosol]
(R-HSA-204630)
0.643
10
UniProt:P50548 ERF
3
p-T526-ERF [nucleoplasm]
(R-HSA-3209166)
p-T526-ERF [cytosol]
(R-HSA-3209167)
ERF [nucleoplasm]
(R-HSA-2534321)
0.643
5
UniProt:P54829 PTPN5
1
PTPN5 [nucleoplasm]
(R-HSA-9008908)
0.643
3
UniProt:Q16539-3 MAPK14
0.628
5
UniProt:P02687 MBP
0.623
2
UniProt:P29353-2 SHC1
6
SHC1-2 [plasma membrane]
(R-HSA-2404168)
p-S29,3Y-SHC1-2 [cytosol]
(R-HSA-8934453)
SHC1-2 [cytosol]
(R-HSA-1169488)
p-Y317-SHC1-2 [cytosol]
(R-HSA-8851895)
p-Y239,Y240,Y317-SHC1-2 [cytosol]
(R-HSA-1433505)
p-Y239,Y240,Y317-SHC1-2 [plasma membrane]
(R-HSA-1169507)
0.618
4
UniProt:P35813 PPM1A
2
PPM1A [cytosol]
(R-HSA-380928)
PPM1A [nucleoplasm]
(R-HSA-205813)
0.611
19
UniProt:P28482 MAPK1
18
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.609
3
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
0.609
2
UniProt:Q16829 DUSP7
2
DUSP7 [cytosol]
(R-HSA-5675346)
DUSP7 [nucleoplasm]
(R-HSA-203791)
0.59
2
UniProt:Q9Y296 TRAPPC4
2
TRAPPC4 [plasma membrane]
(R-HSA-2682314)
TRAPPC4 [cytosol]
(R-HSA-5683764)
0.581
3
UniProt:Q12913 PTPRJ
2
PTPRJ [plasma membrane]
(R-HSA-6785269)
PTPRJ [specific granule membrane]
(R-HSA-6799570)
0.578
7
UniProt:Q05922
1
Dusp2 [nucleoplasm]
(R-MMU-5675340)
0.558
2
UniProt:O76064 RNF8
1
RNF8 [nucleoplasm]
(R-HSA-5682539)
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:Q15256-5 PTPRR
0.556
3
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:P62487 POLR2G
1
POLR2G [nucleoplasm]
(R-HSA-63517)
0.556
3
UniProt:Q6NYC8 PPR18
0.556
3
UniProt:P35548 MSX2
1
MSX2 [nucleoplasm]
(R-HSA-9007760)
0.556
3
UniProt:A0A384NQ31 A0A384NQ31
0.556
3
UniProt:P15882 CHN1
1
CHN1 [cytosol]
(R-HSA-2980571)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9UPG8 PLAL2
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:P61764 STXBP1
2
STXBP1 [cytosol]
(R-HSA-6794256)
STXBP1 [plasma membrane]
(R-HSA-2980862)
0.556
3
UniProt:P28562 DUSP1
1
DUSP1 [nucleoplasm]
(R-HSA-203796)
0.544
3
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.544
2
UniProt:Q16690 DUSP5
1
DUSP5 [nucleoplasm]
(R-HSA-5675342)
0.543
3
UniProt:P14921 ETS1
2
ETS1 [nucleoplasm]
(R-HSA-1629809)
p-T38-ETS1 [nucleoplasm]
(R-HSA-3132720)
0.528
3
UniProt:O75330 HMMR
2
HMMR [plasma membrane]
(R-HSA-2160885)
HMMR [cytosol]
(R-HSA-8861624)
0.527
2
UniProt:Q9HBH9 MKNK2
0.527
2
UniProt:Q8IWJ2 GCC2
3
GCC2 [cytosol]
(R-HSA-6813880)
GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713455)
GCC2(1-1204)-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713458)
0.527
3
UniProt:Q92576 PHF3
0.527
2
UniProt:Q15256-3 PTPRR
0.527
2
UniProt:Q9U1H0 CIC
0.527
2
UniProt:Q9Y573 IPP
0.527
2
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.524
2
UniProt:P53004 BLVRA
1
BLVRA [cytosol]
(R-HSA-189390)
0.499
2
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.488
2
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.488
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.483
3
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.462
2
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