Reactome | HLA-H [plasma membrane]

HLA-H [plasma membrane]

Stable Identifier

R-HSA-6806266

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Putative HLA class I histocompatibility antigen, alpha chain H, HLAH_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
      - Expression of peptide bound class I MHC on cell surface (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
    - Antigen processing-Cross presentation (Homo sapiens)
      - ER-Phagosome pathway (Homo sapiens)
        
        Export of peptide loaded MHC class I complex to PM (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - Endosomal/Vacuolar pathway (Homo sapiens)
        
        Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - LILRs interact with MHC Class I (Homo sapiens)
      - LILR-interacting MHC Class I molecules [plasma membrane] (Homo sapiens)
        
        LILR-binding HLA Class I [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - MHC Class I interacting with LILRs [plasma membrane] (Homo sapiens)
        
        LILR-interacting MHC Class I molecules [plasma membrane] (Homo sapiens)
        
        LILR-binding HLA Class I [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
    - MHC Class I interacts with CD160 (Homo sapiens)
      - MHC Class I interacting with CD160 [plasma membrane] (Homo sapiens)
        
        MHC Class I molecules interacting with CD160 [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - MHC Class I molecules interacting with CD160 [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)
      - Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Neutrophil degranulation (Homo sapiens)
    - Exocytosis of azurophil granule membrane proteins (Homo sapiens)
      - Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01893 HLA-H

Gene Names

HLA-H, HLAH

Chain

signal peptide:1-24, chain:25-362

Reference Genes

HGNC:4965 HLA-H

OMIM:142800 HLA-H

Participates

as a member of

Other forms of this molecule

HLA-H [azurophil granule membrane]

HLA-H [phagocytic vesicle membrane]

HLA-H [recycling endosome membrane]

HLA-H [early endosome membrane]

HLA-H [Golgi membrane]

HLA-H [ER to Golgi transport vesicle membrane]

HLA-H [lumenal side of endoplasmic reticulum membrane]

Inferred To

DLA-79 [plasma membrane] (Canis familiaris)

H2-M1 [plasma membrane] (Mus musculus)

H2-Q7 [plasma membrane] (Mus musculus)

mhc1-uba15 [plasma membrane] (Xenopus tropicalis)

RT1-M3-1 [plasma membrane] (Rattus norvegicus)

LOC100490728 [plasma membrane] (Xenopus tropicalis)

RT1-M1-4 [plasma membrane] (Rattus norvegicus)

H2-M10.3 [plasma membrane] (Mus musculus)

mhc1uma [plasma membrane] (Danio rerio)

H2-M10.4 [plasma membrane] (Mus musculus)

RT1-M1-5 [plasma membrane] (Rattus norvegicus)

H2-M10.6l [plasma membrane] (Rattus norvegicus)

H2-T23 [plasma membrane] (Mus musculus)

H2-K1 [plasma membrane] (Mus musculus)

RT1-N3 [plasma membrane] (Rattus norvegicus)

RT1-O1l1 [plasma membrane] (Rattus norvegicus)

mhc1laa [plasma membrane] (Danio rerio)

LOC119876868 [plasma membrane] (Canis familiaris)

H2-Q1 [plasma membrane] (Mus musculus)

mhc1zda [plasma membrane] (Danio rerio)

mhc1zea [plasma membrane] (Danio rerio)

mhc1zca [plasma membrane] (Danio rerio)

H2-M10.2 [plasma membrane] (Mus musculus)

H2-M5 [plasma membrane] (Mus musculus)

H2-Q6 [plasma membrane] (Mus musculus)

mhc1uba [plasma membrane] (Danio rerio)

mhc1zba [plasma membrane] (Danio rerio)

SLA-6 [plasma membrane] (Sus scrofa)

AABR07044362.1 [plasma membrane] (Rattus norvegicus)

mhc1zfa [plasma membrane] (Danio rerio)

BF1 [plasma membrane] (Gallus gallus)

RT1-M2 [plasma membrane] (Rattus norvegicus)

RT1-A1 [plasma membrane] (Rattus norvegicus)

RT1-CE14 [plasma membrane] (Rattus norvegicus)

ENSRNOG00000064836 [plasma membrane] (Rattus norvegicus)

mhc1-uda [plasma membrane] (Xenopus tropicalis)

mhc1-uea [plasma membrane] (Xenopus tropicalis)

RT1-CE1 [plasma membrane] (Rattus norvegicus)

Homologues of HLA-H [plasma membrane] (Xenopus tropicalis)

RT1-CE16 [plasma membrane] (Rattus norvegicus)

RT1-CE2 [plasma membrane] (Rattus norvegicus)

BOLA [plasma membrane] (Bos taurus)

H2-M10.6 [plasma membrane] (Mus musculus)

SLA-7 [plasma membrane] (Sus scrofa)

Homologues of class I MHC B7 [plasma membrane] (Bos taurus)

Homologues of class I MHC B7 [plasma membrane] (Canis familiaris)

Homologues of class I MHC B7 [plasma membrane] (Danio rerio)

Homologues of class I MHC B7 [plasma membrane] (Gallus gallus)

Homologues of class I MHC B7 [plasma membrane] (Mus musculus)

Homologues of class I MHC B7 [plasma membrane] (Rattus norvegicus)

Homologues of class I MHC B7 [plasma membrane] (Sus scrofa)

AABR07044308.2 [plasma membrane] (Rattus norvegicus)

RT1-M1-2 [plasma membrane] (Rattus norvegicus)

SLA-2 [plasma membrane] (Sus scrofa)

H2-M10.1 [plasma membrane] (Mus musculus)

H2-Q10 [plasma membrane] (Mus musculus)

class I MHC B7 [plasma membrane] (Bos taurus)

class I MHC B7 [plasma membrane] (Canis familiaris)

class I MHC B7 [plasma membrane] (Gallus gallus)

class I MHC B7 [plasma membrane] (Mus musculus)

class I MHC B7 [plasma membrane] (Sus scrofa)

H2-M11 [plasma membrane] (Mus musculus)

H2-Q4 [plasma membrane] (Mus musculus)

mhc1-uba13.5 [plasma membrane] (Xenopus tropicalis)

RT1-S3 [plasma membrane] (Rattus norvegicus)

SLA-8 [plasma membrane] (Sus scrofa)

RT1-M10-1 [plasma membrane] (Rattus norvegicus)

SLA-3 [plasma membrane] (Sus scrofa)

ENSRNOG00000069480 [plasma membrane] (Rattus norvegicus)

H2-T3 [plasma membrane] (Mus musculus)

H2-M10.5 [plasma membrane] (Mus musculus)

RT1-M5 [plasma membrane] (Rattus norvegicus)

H2-D1 [plasma membrane] (Mus musculus)

DLA88 [plasma membrane] (Canis familiaris)

H2-M3 [plasma membrane] (Mus musculus)

BFIV21 [plasma membrane] (Gallus gallus)

H2-Q2 [plasma membrane] (Mus musculus)

H2-M9 [plasma membrane] (Mus musculus)

LOC100513601 [plasma membrane] (Sus scrofa)

DLA-12 [plasma membrane] (Canis familiaris)

H2-M2 [plasma membrane] (Mus musculus)

BOLA-NC1 [plasma membrane] (Bos taurus)

H2-T22 [plasma membrane] (Mus musculus)

mr1l [plasma membrane] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000206341

GeneCards

P01893

PRO

P01893

Pharos - Targets

P01893

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.558	2

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