Reactome | VAPA [plasma membrane]

VAPA [plasma membrane]

Stable Identifier

R-HSA-6806269

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

VAMP-associated protein A

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9P0L0 VAPA

Gene Names

VAPA, VAP33

Chain

initiator methionine:, chain:2-249

Reference Genes

BioGPS Gene:9218 VAPA

COSMIC (genes):VAPA VAPA

CTD Gene:9218 VAPA

dbSNP Gene:9218 VAPA

ENSEMBL:ENSG00000101558 VAPA

ENSEMBL_homo_sapiens_GENE:ENSG00000101558.14 VAPA

HGNC:12648 VAPA

KEGG Gene (Homo sapiens):9218 VAPA

Monarch:9218 VAPA

NCBI Gene:9218 VAPA

OMIM:605703 VAPA

UCSC:Q9P0L0 VAPA

Reference Transcript

Other Identifiers

11725316_x_at

11725317_s_at

11743255_a_at

11743256_s_at

11743257_x_at

11754029_a_at

11754086_x_at

16850944

208780_PM_x_at

208780_x_at

225198_PM_at

225198_at

228480_PM_at

228480_at

239750_PM_x_at

239750_x_at

3638294

3638295

3778602

3778603

3778610

3778612

3778615

3778618

3778619

3778622

3778626

3778627

3778628

3778629

3778630

3778631

3778632

3778633

38801_at

46029_r_at

54663_at

63624_at

8020129

88498_at

89329_at

9218

A_23_P207957

A_23_P382199

A_33_P3419460

GE55653

GE576751

GE81305

GE86002

GE88533

GO:0000139

GO:0005515

GO:0005634

GO:0005635

GO:0005764

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005923

GO:0006629

GO:0006686

GO:0006888

GO:0008017

GO:0008092

GO:0015630

GO:0015914

GO:0015918

GO:0016020

GO:0016192

GO:0019076

GO:0019904

GO:0023052

GO:0030154

GO:0030301

GO:0031175

GO:0031410

GO:0031965

GO:0031982

GO:0033149

GO:0035577

GO:0035627

GO:0042803

GO:0043123

GO:0043226

GO:0044828

GO:0044829

GO:0045296

GO:0046982

GO:0048471

GO:0048856

GO:0061024

GO:0061025

GO:0061817

GO:0070161

GO:0070972

GO:0090114

HMNXSV003039333

Hs.165195.0.S1_3p_at

Hs.165195.1.A1_3p_at

Hs.65082.0.A1_3p_at

ILMN_1690822

ILMN_1779410

ILMN_2405190

PH_hs_0029289

TC18000049.hg

g8099349_3p_a_at

g8099349_3p_x_at

Participates

as a member of

Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)

Other forms of this molecule

VAPA [endoplasmic reticulum membrane]

VAPA [azurophil granule membrane]

VAPA [cytosol]

Inferred To

vapal [plasma membrane] (Danio rerio)

Vap33 [plasma membrane] (Drosophila melanogaster)

SCS2 [plasma membrane] (Saccharomyces cerevisiae)

VAPA [plasma membrane] (Bos taurus)

VAPA [plasma membrane] (Canis familiaris)

VAPA [plasma membrane] (Dictyostelium discoideum)

VAPA [plasma membrane] (Gallus gallus)

VAPA [plasma membrane] (Plasmodium falciparum)

VAPA [plasma membrane] (Sus scrofa)

scs2 [plasma membrane] (Schizosaccharomyces pombe)

vapa [plasma membrane] (Xenopus tropicalis)

vpr-1 [plasma membrane] (Caenorhabditis elegans)

Vapa [plasma membrane] (Mus musculus)

Vapa [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_919415.2, NP_003565.4

OpenTargets

ENSG00000101558

HPA

ENSG00000101558-VAPA

GeneCards

Q9P0L0

Ensembl

ENST00000400000, ENSP00000345656, ENST00000340541, ENSG00000101558, ENSP00000382880

PRO

Q9P0L0

Pharos - Targets

Q9P0L0

PDB

6TQR, 2RR3

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22059 OSBP	1	OSBP [cytosol] (R-HSA-429725)	0.848	9
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274)	0.725	5
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.725	5
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.718	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.713	4
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.675	4
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.666	5
UniProt:Q8WXG1 RSAD2	1	RSAD2 [endoplasmic reticulum membrane] (R-HSA-5624199)	0.661	10
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668)	0.643	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.64	13
UniProt:Q9NZN5 ARHGEF12	1	ARHGEF12 [cytosol] (R-HSA-416560)	0.615	6
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.602	3
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	5
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3
UniProt:O00559 EBAG9	1	EBAG9 [Golgi membrane] (R-HSA-9018507)	0.556	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.547	2
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [azurophil granule membrane] (R-HSA-6799559) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [specific granule membrane] (R-HSA-6799552) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.527	3
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4

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