Reactome | HSPB8 [nucleoplasm]

HSPB8 [nucleoplasm]

Stable Identifier

R-HSA-6806337

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heat shock protein beta-8, Alpha-crystallin C chain, CRYAC, HSP22

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - HSF1-dependent transactivation (Homo sapiens)
      - HSF1-mediated gene expression (Homo sapiens)
        
        Heat shock inducible proteins [nucleoplasm] (Homo sapiens)
        
        HSPB8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJY1 HSPB8

Gene Names

HSPB8, CRYAC, E2IG1, HSP22, PP1629

Chain

chain:1-196

Reference Genes

BioGPS Gene:26353 HSPB8

COSMIC (genes):HSPB8 HSPB8

CTD Gene:26353 HSPB8

dbSNP Gene:26353 HSPB8

ENSEMBL:ENSG00000152137 HSPB8

ENSEMBL_homo_sapiens_GENE:ENSG00000152137.8 HSPB8

HGNC:30171 HSPB8

KEGG Gene (Homo sapiens):26353 HSPB8

Monarch:26353 HSPB8

NCBI Gene:26353 HSPB8

OMIM:608014 HSPB8

UCSC:Q9UJY1 HSPB8

Reference Transcript

RefSeq:NM_014365.2 HSPB8

Other Identifiers

11715775_a_at

11715776_a_at

221667_PM_s_at

221667_s_at

26353

2818833

2921340

2921341

3063255

3063259

3063262

3434014

3434015

3434019

3434022

3434023

3434024

3434025

3434026

3434027

3434028

3434029

3434030

56474_at

7959102

A_23_P123256

A_23_P162579

GE58582

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006914

GO:0034620

GO:0042802

GO:0042803

GO:0043226

GO:0101031

GO:1905337

HMNXSV003019820

ILMN_1791280

PH_hs_0029092

TC12000932.hg

g5901654_3p_a_at

Participates

as a member of

Heat shock inducible proteins [nucleoplasm] (Homo sapiens)

Inferred To

HSPB8 [nucleoplasm] (Bos taurus)

HSPB8 [nucleoplasm] (Canis familiaris)

HSPB8 [nucleoplasm] (Gallus gallus)

HSPB8 [nucleoplasm] (Sus scrofa)

Hspb8 [nucleoplasm] (Mus musculus)

Hspb8 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_055180.1

OpenTargets

ENSG00000152137

GeneCards

Q9UJY1

HPA

ENSG00000152137-HSPB8

Ensembl

ENST00000281938, ENSP00000281938, ENSG00000152137

PRO

Q9UJY1

Pharos - Targets

Q9UJY1

Orphanet

16231

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.643	3
UniProt:Q9BQG2 NUDT12	1	NUDT12 [peroxisomal matrix] (R-HSA-6809221)	0.643	4
UniProt:P49247 RPIA	2	RPIA [cytosol] (R-HSA-71304) RPIA A61V [cytosol] (R-HSA-5660009)	0.556	3
UniProt:Q709F0 ACAD11	1	ACAD11 [mitochondrial inner membrane] (R-HSA-5695987)	0.527	3
UniProt:Q9BYW2 SETD2	1	SETD2 [nucleoplasm] (R-HSA-1183220)	0.527	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.454	3

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