TP53 and AP-1 stimulate MSH2 expression

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R-HSA-6806394
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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TP53 and the AP-1 transcription factor complex cooperatively stimulate transcription of the MSH2 gene, involved in DNA mismatch repair, by binding to adjacent sites in the MSH2 promoter (Scherer et al. 2001). TP53 may stimulate transcription of MSH2 independently of the AP-1 complex when bound to a different p53 response element in the MSH2 promoter (Warnick et al. 2001).

Literature References
PubMed ID Title Journal Year
11350971 Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells

Warnick, CT, Dabbas, B, Ford, CD, Strait, KA

J. Biol. Chem. 2001
10984493 p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV

Scherer, SJ, Maier, SM, Seifert, M, Hanselmann, RG, Zang, KD, Müller-Hermelink, HK, Angel, P, Welter, C, Schartl, M

J. Biol. Chem. 2000
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