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CAT [extracellular region]
Stable Identifier
R-HSA-6806458
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Catalase apoprotein (EC 1.11.1.6), CATA_HUMAN, Catalase
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
CAT [extracellular region] (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
CAT [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
10656833
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
Tainer, JA
,
Arvai, AS
,
Bourne, Y
,
Putnam, CD
J Mol Biol
2000
External Reference Information
External Reference
UniProt:P04040 CAT
Gene Names
CAT
Chain
initiator methionine:, chain:2-527
Reference Genes
BioGPS Gene:847 CAT
COSMIC (genes):CAT CAT
CTD Gene:847 CAT
dbSNP Gene:847 CAT
ENSEMBL:ENSG00000121691 CAT
ENSEMBL_homo_sapiens_GENE:ENSG00000121691.7 CAT
HGNC:1516 CAT
KEGG Gene (Homo sapiens):847 CAT
Monarch:847 CAT
NCBI Gene:847 CAT
OMIM:115500 CAT
UCSC:P04040 CAT
Reference Transcript
RefSeq:NM_001752.3 CAT
Other Identifiers
11732147_a_at
11732148_at
16723546
201432_PM_at
201432_at
211922_PM_s_at
211922_s_at
3326401
3326402
3326408
3326409
3326410
3326411
3326412
3326414
3326416
3326420
3326423
3326425
3326428
3326429
3326430
3326431
3326432
3326433
3326434
37009_at
7939298
847
A_23_P105138
GE61602
GO:0000302
GO:0001649
GO:0001657
GO:0001666
GO:0001822
GO:0003824
GO:0004046
GO:0004096
GO:0004601
GO:0005576
GO:0005615
GO:0005737
GO:0005739
GO:0005777
GO:0005778
GO:0005782
GO:0005829
GO:0005925
GO:0006091
GO:0006629
GO:0006641
GO:0006979
GO:0008203
GO:0009060
GO:0009410
GO:0009411
GO:0009636
GO:0009642
GO:0009650
GO:0010193
GO:0010288
GO:0012501
GO:0014823
GO:0014854
GO:0016020
GO:0016209
GO:0016491
GO:0016684
GO:0016787
GO:0019899
GO:0020027
GO:0020037
GO:0023052
GO:0030154
GO:0031410
GO:0032355
GO:0032868
GO:0032991
GO:0033189
GO:0033197
GO:0033591
GO:0034774
GO:0042542
GO:0042744
GO:0042802
GO:0042803
GO:0043066
GO:0043226
GO:0043231
GO:0045471
GO:0046686
GO:0046872
GO:0048856
GO:0050661
GO:0051781
GO:0051897
GO:0055093
GO:0061692
GO:0062151
GO:0070062
GO:0070542
GO:0071363
GO:0080184
GO:0098754
GO:0098869
GO:1904813
HMNXSV003031029
ILMN_1651705
ILMN_2151739
PH_hs_0018945
TC11000327.hg
X04085_rna1_at
g13562131_3p_s_at
g4557013_3p_at
Participates
as a member of
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
CAT [peroxisomal matrix]
CAT [ficolin-1-rich granule lumen]
CAT [secretory granule lumen]
CAT [cytosol]
Inferred To
CAT [extracellular region]
(Bos taurus)
CAT [extracellular region]
(Caenorhabditis elegans)
CAT [extracellular region]
(Canis familiaris)
CAT [extracellular region]
(Danio rerio)
CAT [extracellular region]
(Dictyostelium discoideum)
CAT [extracellular region]
(Drosophila melanogaster)
CAT [extracellular region]
(Gallus gallus)
CAT [extracellular region]
(Mus musculus)
CAT [extracellular region]
(Rattus norvegicus)
CAT [extracellular region]
(Saccharomyces cerevisiae)
CAT [extracellular region]
(Schizosaccharomyces pombe)
CAT [extracellular region]
(Sus scrofa)
CAT [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001743.1
Guide to Pharmacology - Targets
2979
OpenTargets
ENSG00000121691
GeneCards
P04040
HPA
ENSG00000121691-CAT
Ensembl
ENSG00000121691
,
ENST00000241052
,
ENSP00000241052
PRO
P04040
Pharos - Targets
P04040
Orphanet
15402
HMDB Protein
HMDBP01582
PDB
8EL9
,
7P8W
,
1DGG
,
1QQW
,
7VD9
,
1DGB
,
8SGV
,
1F4J
,
8HID
,
8PVD
,
1DGF
,
1DGH
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04040 CAT
5
CAT [peroxisomal matrix]
(R-HSA-51417)
CAT [ficolin-1-rich granule lumen]
(R-HSA-6801279)
CAT [extracellular region]
(R-HSA-6806458)
CAT [secretory granule lumen]
(R-HSA-6801311)
CAT [cytosol]
(R-HSA-9033141)
0.594
5
UniProt:Q2T9J0 TYSND1
4
TYSND1(111-566) [peroxisomal matrix]
(R-HSA-9033589)
TYSND1(1-110) [peroxisomal matrix]
(R-HSA-9033587)
TYSND1 [peroxisomal matrix]
(R-HSA-8933309)
TYSND1 [cytosol]
(R-HSA-9033586)
0.548
4
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.544
3
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.483
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
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