Reactome | PSMA5 [extracellular region]

PSMA5 [extracellular region]

Stable Identifier

R-HSA-6806459

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Proteasome subunit alpha type 5 , Proteasome zeta chain, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28066 PSMA5

Gene Names

PSMA5

Chain

chain:1-241

Reference Genes

BioGPS Gene:5686 PSMA5

COSMIC (genes):PSMA5 PSMA5

CTD Gene:5686 PSMA5

dbSNP Gene:5686 PSMA5

ENSEMBL:ENSG00000143106 PSMA5

HGNC:9534 PSMA5

KEGG:hsa:5686 PSMA5

Monarch:5686 PSMA5

NCBI Gene:5686 PSMA5

OMIM:176844 PSMA5

UCSC:P28066 PSMA5

Reference Transcript

Other Identifiers

11715668_a_at

16690594

201274_PM_at

201274_at

230300_PM_at

230300_at

2427066

2427067

2427068

2427069

2427070

2427071

2427072

2427073

2427075

2427076

2427077

2427078

2427079

2427080

2427088

2427090

2427091

2427092

2427093

2427094

2427095

2427096

2427097

2427098

2427102

2427103

2427104

2427105

2427106

2427107

37046_at

5686

61368_at

73310_at

7918345

A_23_P86216

GE59874

GE824853

GO:0000502

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0010498

GO:0019773

GO:0030163

GO:0034774

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:1904813

HMNXSV003024721

Hs.26037.0.A1_3p_at

ILMN_1759952

PH_hs_0002295

PH_hs_0004438

TC01002955.hg

TC01005688.hg

X61970_at

g4506186_3p_s_at

Participates

as a member of

Other forms of this molecule

PSMA5 [cytosol]

PSMA5 [nucleoplasm]

PSMA5 [secretory granule lumen]

PSMA5 [ficolin-1-rich granule lumen]

Inferred To

pup2 [extracellular region] (Schizosaccharomyces pombe)

Psma5 [extracellular region] (Mus musculus)

Psma5 [extracellular region] (Rattus norvegicus)

psma5 [extracellular region] (Danio rerio)

psma5 [extracellular region] (Xenopus tropicalis)

Prosalpha5 [extracellular region] (Drosophila melanogaster)

psmA5 [extracellular region] (Dictyostelium discoideum)

PUP2 [extracellular region] (Saccharomyces cerevisiae)

pas-5 [extracellular region] (Caenorhabditis elegans)

PSMA5 [extracellular region] (Bos taurus)

PSMA5 [extracellular region] (Canis familiaris)

PSMA5 [extracellular region] (Gallus gallus)

PSMA5 [extracellular region] (Plasmodium falciparum)

PSMA5 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002781.2, NP_001186703.1, NP_001186701.1, NP_001186702.1

OpenTargets

ENSG00000143106

ENSEMBL

ENST00000271308, ENST00000538610, ENSP00000440618, ENSP00000271308

HPA

ENSG00000143106-PSMA5

PRO

P28066

Pharos - Targets

P28066

GlyGen

P28066

PDB

8QYJ, 7QY7, 7QXP, 7QXX, 7W3I, 7V5M, 6WJN, 8QYN, 7W3H, 7W39, 7NAN, 7W3B, 6MSB, 6MSJ, 5LF1, 6MSK, 5VFS, 6KWY, 7B12, 5VFU, 6MSG, 5VFR, 7W3C, 8QZ9, 6AVO, 5VFO, 8QYS, 7QXW, 6E5B, 8CXB, 7LXV, 5LEZ, 5LEY, 5LF3, 4R67, 7W38, 5T0H, 5T0I, 5T0C, 8CVR, 5L4G, 7PG9, 7QYA, 6MSE, 7W3M, 7W3K, 8UD9, 7QXU, 5GJQ, 7W3A, 7W3G, 7W3J, 7NAP, 7W37, 8QYL, 7NAQ, 8QYO, 5LN3, 7NAO, 8QYM, 5LF0, 6WJD, 5VFT, 6MSH, 6XMJ, 6RGQ, 5A0Q, 5VFQ, 7QXN, 7W3F, 5GJR, 5VFP, 6MSD, 7V5G, 7NHT, 6R70, 7AWE, 5LF6, 5LEX, 5LF4, 5LF7, 5M32, 4R3O, 5T0G, 5T0J, 5LE5, 8CVT, 6REY, 8CVS, 7QYB, 8BZL

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.913	16
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.744	6
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.725	9
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.725	6
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.688	3
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.669	5
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.643	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	6
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.643	6
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.643	6
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.643	5
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.638	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	5
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.527	4
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.527	4
UniProt:Q5JS54 PSMG4	1	PSMG4 [cytosol] (R-HSA-9908036)	0.527	4
UniProt:O95456 PSMG1	1	PSMG1 [cytosol] (R-HSA-9908050)	0.527	5
UniProt:Q9BT73 PSMG3	1	PSMG3 [cytosol] (R-HSA-9908033)	0.527	4
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	4
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.527	4
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	4
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.527	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	4
UniProt:P28072 PSMB6	4	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6(1-34) [cytosol] (R-HSA-9908141)	0.527	4
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.527	5
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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