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HUWE1 [extracellular region]
Stable Identifier
R-HSA-6806466
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
E3 ubiquitin-protein ligase HUWE1, HUWE1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
HUWE1 [extracellular region] (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
HUWE1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7Z6Z7 HUWE1
Gene Names
HUWE1, KIAA0312, KIAA1578, UREB1, HSPC272
Chain
chain:1-4374
Reference Genes
BioGPS Gene:10075 HUWE1
COSMIC (genes):HUWE1 HUWE1
CTD Gene:10075 HUWE1
dbSNP Gene:10075 HUWE1
ENSEMBL:ENSG00000086758 HUWE1
ENSEMBL_homo_sapiens_GENE:ENSG00000086758.17 HUWE1
HGNC:30892 HUWE1
KEGG Gene (Homo sapiens):10075 HUWE1
Monarch:10075 HUWE1
NCBI Gene:10075 HUWE1
OMIM:300697 HUWE1
UCSC:Q7Z6Z7 HUWE1
Reference Transcript
RefSeq:NM_031407.6 HUWE1
RefSeq:XM_005261965.3 HUWE1
Other Identifiers
10075
11717751_a_at
11752863_s_at
11754690_a_at
17111262
208598_PM_s_at
208598_s_at
214673_PM_s_at
214673_s_at
236294_PM_at
236294_at
34372_at
34374_g_at
4009316
4009317
4009318
4009319
4009320
4009321
4009327
4009328
4009329
4009330
4009332
4009333
4009334
4009337
4009338
4009340
4009341
4009342
4009343
4009344
4009346
4009347
4009348
4009350
4009351
4009352
4009353
4009355
4009356
4009357
4009358
4009359
4009360
4009361
4009362
4009363
4009364
4009365
4009366
4009367
4009368
4009373
4009374
4009375
4009377
4009379
4009380
4009381
4009383
4009384
4009388
4009389
4009391
4009392
4009393
4009394
4009395
4009396
4009397
4009398
4009399
4009400
4009401
4009402
4009404
4009406
4009407
4009408
4009409
4009410
4009411
4009412
4009413
4009414
4009415
4009416
4009417
4009418
4009419
4009420
4009421
4009422
4009425
4009426
4009427
4009431
4009432
4009435
4009437
4009441
4009442
4009444
4009445
4009448
4009449
4009451
4009452
4009453
4009454
4009455
4009456
4009457
4009458
4009459
4009460
4009461
4009462
4009463
4009466
4009470
4009476
4009477
4009478
4009481
4009482
4009483
4009484
8172914
84360_at
A_19_P00319331
A_19_P00322829
A_23_P219207
A_24_P932016
A_33_P3811287
GE53048
GE85820
GE88008
GO:0000139
GO:0000209
GO:0003677
GO:0003723
GO:0003824
GO:0004842
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005794
GO:0005829
GO:0006281
GO:0006284
GO:0006325
GO:0006338
GO:0006513
GO:0006886
GO:0006914
GO:0006974
GO:0007005
GO:0007030
GO:0010637
GO:0016020
GO:0016567
GO:0016740
GO:0030154
GO:0031398
GO:0031410
GO:0032922
GO:0034774
GO:0036211
GO:0043226
GO:0048511
GO:0048856
GO:0061024
GO:0061025
GO:0061630
GO:0070062
GO:0098779
GO:0140096
GO:0140852
GO:1903955
GO:1904813
HMNXSV003007258
Hs.155101.4.S1_3p_a_at
Hs.167040.0.A1_3p_at
Hs.167040.0.A1_3p_x_at
ILMN_1790987
TC0X001067.hg
TC0X002079.hg
Z97054_xpt2_at
g6692990_3p_a_at
Participates
as a member of
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
HUWE1 [secretory granule lumen]
HUWE1 [ficolin-1-rich granule lumen]
HUWE1 [cytosol]
Inferred To
ptr1 [extracellular region]
(Schizosaccharomyces pombe)
HUWE1 [extracellular region]
(Bos taurus)
HUWE1 [extracellular region]
(Canis familiaris)
HUWE1 [extracellular region]
(Dictyostelium discoideum)
HUWE1 [extracellular region]
(Drosophila melanogaster)
HUWE1 [extracellular region]
(Plasmodium falciparum)
HUWE1 [extracellular region]
(Sus scrofa)
eel-1 [extracellular region]
(Caenorhabditis elegans)
Huwe1 [extracellular region]
(Mus musculus)
TOM1 [extracellular region]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_113584.3
,
XP_005262022.1
OpenTargets
ENSG00000086758
IntEnz
2.3.2.26
GeneCards
Q7Z6Z7
HPA
ENSG00000086758-HUWE1
Ensembl
ENSG00000086758
,
ENSP00000340648
,
ENSP00000262854
,
ENST00000262854
,
ENST00000612484
,
ENST00000342160
,
ENSP00000479451
PRO
Q7Z6Z7
Pharos - Targets
Q7Z6Z7
Orphanet
18651
HMDB Protein
HMDBP09257
PDB
6MIW
,
7MOP
,
7AZX
,
2EKK
,
2MUL
,
6PFL
,
7JQ9
,
7MWF
,
7MWD
,
5LP8
,
3G1N
,
6FYH
,
5C6H
,
7MWE
,
3H1D
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.841
11
UniProt:Q8N726 CDKN2A
12
p14ARF [nucleoplasm]
(R-HSA-1629813)
p14ARF [cytosol]
(R-HSA-9645669)
p14ARF [mitochondrial matrix]
(R-HSA-9645695)
p14ARF R98L;R99S [cytosol]
(R-HSA-9645730)
p14ARF R82C [cytosol]
(R-HSA-9645750)
p14ARF R90H [cytosol]
(R-HSA-9645755)
p14ARF R88Q [cytosol]
(R-HSA-9645754)
p14ARF R87C [cytosol]
(R-HSA-9645759)
p14ARF R81G [cytosol]
(R-HSA-9645741)
p14ARF R98Q [cytosol]
(R-HSA-9645757)
p14ARF R99C [cytosol]
(R-HSA-9645756)
p14ARF V22Pfs*46 [cytosol]
(R-HSA-9646285)
0.677
5
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.527
2
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.524
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.508
3
UniProt:P20393 NR1D1
1
NR1D1 [nucleoplasm]
(R-HSA-375499)
0.499
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
9
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