Reactome | PFKL [extracellular region]

PFKL [extracellular region]

Stable Identifier

R-HSA-6806471

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

6-phosphofructokinase, liver type , Phosphofructokinase 1, Phosphohexokinase, Phosphofructo-1-kinase isozyme B, PFK-B

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P17858 PFKL

Gene Names

PFKL

Chain

initiator methionine:, chain:2-780

Reference Genes

BioGPS Gene:5211 PFKL

COSMIC (genes):PFKL PFKL

CTD Gene:5211 PFKL

dbSNP Gene:5211 PFKL

ENSEMBL:ENSG00000141959 PFKL

HGNC:8876 PFKL

KEGG:hsa:5211 PFKL

Monarch:5211 PFKL

NCBI Gene:5211 PFKL

OMIM:171860 PFKL

UCSC:P17858 PFKL

Reference Transcript

Other Identifiers

11730211_x_at

11744335_x_at

11752746_a_at

16922993

201102_3p_s_at

201102_PM_s_at

201102_s_at

211065_3p_x_at

211065_PM_x_at

211065_x_at

214309_PM_s_at

214309_s_at

3923634

3923635

3923641

3923642

3923643

3923644

3923645

3923646

3923648

3923650

3923651

3923652

3923653

3923654

3923655

3923656

3923657

3923658

3923659

3923660

3923661

3923664

3923665

3923666

3923667

3923668

3923669

3923670

3923671

3923672

3923673

3923674

3923676

3923678

3923679

3923680

3923681

3923682

3923683

3923684

3923685

3923686

3923687

3923689

40116_at

5211

8069057

A_14_P103600

A_23_P29079

A_23_P29081

GE59729

GE84424

GE84746

GO:0003824

GO:0003872

GO:0005515

GO:0005524

GO:0005576

GO:0005737

GO:0005829

GO:0005945

GO:0005975

GO:0006002

GO:0006091

GO:0006096

GO:0009749

GO:0016020

GO:0016208

GO:0016301

GO:0016740

GO:0019900

GO:0030388

GO:0034774

GO:0042802

GO:0043226

GO:0046676

GO:0046872

GO:0048029

GO:0055086

GO:0061615

GO:0061621

GO:0070061

GO:0070062

GO:0070095

GO:1901135

GO:1904813

HMNXSV003005798

Hs.153452.3.A1_3p_a_at

Hs.153452.3.A1_3p_x_at

ILMN_1713037

ILMN_2287253

PH_hs_0024080

PH_hs_0032896

TC21000222.hg

TC21000768.hg

X15573_at

g13623608_3p_s_at

g4505746_3p_s_at

Participates

as a member of

Other forms of this molecule

PFKL [ficolin-1-rich granule lumen]

PFKL [secretory granule lumen]

PFKL [cytosol]

Inferred To

Homologues of PFKL [extracellular region] (Caenorhabditis elegans)

Homologues of PFKL [extracellular region] (Saccharomyces cerevisiae)

PFKL [extracellular region] (Bos taurus)

PFKL [extracellular region] (Caenorhabditis elegans)

PFKL [extracellular region] (Canis familiaris)

PFKL [extracellular region] (Drosophila melanogaster)

PFKL [extracellular region] (Gallus gallus)

PFKL [extracellular region] (Mus musculus)

PFKL [extracellular region] (Rattus norvegicus)

PFKL [extracellular region] (Saccharomyces cerevisiae)

PFKL [extracellular region] (Schizosaccharomyces pombe)

PFKL [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002617.3, NP_001002021.2

ENSEMBL

ENSP00000269848, ENST00000349048

OpenTargets

ENSG00000141959

HPA

ENSG00000141959-PFKL

PRO

P17858

Pharos - Targets

P17858

GlyGen

P17858

HMDB Protein

HMDBP00758

PDB

7LW1

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.556	3