Reactome | PSMD12 [extracellular region]

PSMD12 [extracellular region]

Stable Identifier

R-HSA-6806480

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

26S proteasome non-ATPase regulatory subunit 12, 26S proteasome regulatory subunit p55

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O00232 PSMD12

Gene Names

PSMD12

Chain

initiator methionine:, chain:2-456

Reference Genes

BioGPS Gene:5718 PSMD12

COSMIC (genes):PSMD12 PSMD12

CTD Gene:5718 PSMD12

dbSNP Gene:5718 PSMD12

ENSEMBL:ENSG00000197170 PSMD12

ENSEMBL_homo_sapiens_GENE:ENSG00000197170.10 PSMD12

HGNC:9557 PSMD12

KEGG Gene (Homo sapiens):5718 PSMD12

Monarch:5718 PSMD12

NCBI Gene:5718 PSMD12

OMIM:604450 PSMD12

UCSC:O00232 PSMD12

Reference Transcript

Other Identifiers

11732779_a_at

11739251_a_at

11758041_s_at

11759291_s_at

1192_at

16848032

202352_PM_s_at

202352_s_at

202353_PM_s_at

202353_s_at

2682615

2682617

2682620

3768104

3768105

3768106

3768107

3768108

3768109

3768110

3768111

3768112

3768113

3768114

3768117

3768119

3768120

3768121

3768122

3768123

3768126

3768128

3768136

3768137

3768138

5718

8017810

AB003103_at

A_23_P112613

A_23_P77876

A_32_P12639

GE53110

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0008541

GO:0016020

GO:0022624

GO:0030163

GO:0031410

GO:0034774

GO:0043161

GO:0043226

GO:0070062

GO:1904813

HMNXSV003048354

Hs.4295.0.S1_3p_a_at

ILMN_1691428

ILMN_2368971

PH_hs_0000479

TC17001813.hg

g4506220_3p_a_at

Participates

as a member of

Other forms of this molecule

PSMD12 [secretory granule lumen]

PSMD12 [ficolin-1-rich granule lumen]

PSMD12 [nucleoplasm]

PSMD12 [cytosol]

Inferred To

PSMD12 [extracellular region] (Bos taurus)

PSMD12 [extracellular region] (Canis familiaris)

PSMD12 [extracellular region] (Gallus gallus)

PSMD12 [extracellular region] (Plasmodium falciparum)

PSMD12 [extracellular region] (Sus scrofa)

RPN5 [extracellular region] (Saccharomyces cerevisiae)

psmD12 [extracellular region] (Dictyostelium discoideum)

Homologues of PSMD12 [extracellular region] (Schizosaccharomyces pombe)

Rpn5 [extracellular region] (Drosophila melanogaster)

rpn-5 [extracellular region] (Caenorhabditis elegans)

Psmd12 [extracellular region] (Mus musculus)

Psmd12 [extracellular region] (Rattus norvegicus)

psmd12 [extracellular region] (Danio rerio)

psmd12 [extracellular region] (Xenopus tropicalis)

rpn502 [extracellular region] (Schizosaccharomyces pombe)

rpn501 [extracellular region] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001303270.1, NP_777360.1, NP_002807.1

OpenTargets

ENSG00000197170

HPA

ENSG00000197170-PSMD12

GeneCards

O00232

Ensembl

ENSP00000349667, ENSP00000348442, ENST00000356126, ENSG00000197170, ENST00000357146

PRO

O00232

Pharos - Targets

O00232

Orphanet

27829

PDB

5VFS, 5VFR, 7W3M, 5LN3, 7QXW, 5M32, 6MSJ, 5VFU, 5T0G, 5VFT, 6MSK, 7QY7, 5T0C, 5VHI, 5VFP, 6MSE, 7W3I, 7W39, 6MSD, 7W38, 7QXN, 7W3B, 5L4K, 6MSH, 6MSG, 7QXP, 7W3A, 5VHS, 7QXX, 7W3F, 7W3C, 5VGZ, 6WJD, 8CVT, 6MSB, 5VHF, 7W3H, 7W3G, 5VHH, 5GJQ, 7W37, 5GJR, 6WJN, 5T0H, 7QYB, 5T0I, 7QYA, 5T0J, 7W3K, 5VFQ, 7QXU, 7W3J

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.804	7
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.802	7
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.802	6
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.643	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	15
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.589	2
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.564	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5

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